BAK1 BCL2 antagonist/killer 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: BAK1provided by HGNC
Official Full Name: BCL2 antagonist/killer 1provided by HGNC
Primary source: HGNC:HGNC:949
See related: Ensembl:ENSG00000030110 MIM:600516
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BAK; CDN1; BCL2L7; BAK-LIKE
Summary: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in duodenum (RPKM 20.6), small intestine (RPKM 16.4) and 25 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 6p21.31

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
109	current	GRCh38.p12 (GCF_000001405.38)	6	NC_000006.12 (33572546..33580296, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (33540323..33548072, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Our findings suggested that ZBP-89 and Sp1 overexpression induced Bak expression in a genetic manner. Increased Bak level was associated with poor patient survival, whereas high level of Sp1 is a beneficial factor for patient survival.
Title: ZBP-89 and Sp1 contribute to Bak expression in hepatocellular carcinoma cells.
Study reports the proximal alpha1-alpha2 loop as a second activation site in Bak and in mitochondrial Bax.
Title: Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies.
The proapoptotic BCL-2 proteins BAX and BAK can commit a cell to its programmed death by permeabilizing the outer mitochondrial membrane and subsequent initiation of the caspase cascade. (Review)
Title: BCL-2 proteins and apoptosis: Recent insights and unknowns.
Data suggest that ECAD, STAT3, Bak, and Bcl-xL are expressed in affected endometrial tissues of women with endometrioid adenocarcinoma depending on neoplasm staging and cell differentiation. This study was conducted using immunohistochemistry of surgically resected tissues. (ECAD = E-cadherin; STAT3 = signal transducer and activator of transcription 3 protein; Bcl-xL = BCL2 associated agonist of cell death)
Title: Comparison of E-cadherin with STAT3 and apoptosis regulators: Bak and Bcl-xL in endometrioid adenocarcinomas of different ER-alpha immunoprofile.
This comprehensive survey showed that in each Bak dimer the N-termini are fully solvent-exposed and mobile, the core is highly structured, and the C-termini are flexible but restrained by their contact with the membrane.
Title: Disordered clusters of Bak dimers rupture mitochondria during apoptosis.
The BAK1/BCL2 ratio was positively correlated with the results of audiometric tests. Our results indicate that BAK-mediated apoptosis may be a core mechanism in the progression of age-related hearing impairment in humans
Title: Expression levels of the BAK1 and BCL2 genes highlight the role of apoptosis in age-related hearing impairment.
UMI-77 enhances TRAIL-induced apoptosis by unsequestering Bim and Bak, which provides a novel therapeutic strategy for the treatment of gliomas.
Title: UMI-77 primes glioma cells for TRAIL-induced apoptosis by unsequestering Bim and Bak from Mcl-1.
after the induction of apoptosis, Bak switches from its association with Mtx2 and VDAC2 to a closer association with Mtx1.
Title: The phosphorylation of Metaxin 1 controls Bak activation during TNFα induced cell death.
Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Title: Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
The results strongly suggest that the direct apoptosis-activation activities of Bid, Bim, Puma, and p53 are not essential for activating Bax/Bak once the anti-apoptotic Bcl-2 proteins are neutralized.
Title: Bax/Bak activation in the absence of Bid, Bim, Puma, and p53.

Submit: New GeneRIF Correction See all GeneRIFs (200)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
A genome-wide association study of testicular germ cell tumor. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association study of hematological and biochemical traits in a Japanese population. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Meta-analysis identifies four new loci associated with testicular germ cell tumor. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
New gene functions in megakaryopoiesis and platelet formation. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat induces apoptosis of human blood-retinal barrier-associated cells by downregulation of BCL2 and upregulation of BAK, BAX, and cytochrome c in a dose-dependent manner	PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Go to the top of the page Help

Activation and oligomerization of BAK protein, organism-specific biosystem (from REACTOME)
Activation and oligomerization of BAK protein, organism-specific biosystemtBID binds to its mitochondrial partner BAK to release cytochrome c. Activated tBID results in an allosteric activation of BAK. This may induce its intramembranous oligomerization into a pore for cy...
Apoptosis, organism-specific biosystem (from KEGG)
Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
Apoptosis, organism-specific biosystem (from WikiPathways)
Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
Apoptosis, conserved biosystem (from KEGG)
Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
Apoptosis, organism-specific biosystem (from REACTOME)
Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
Apoptosis - multiple species, organism-specific biosystem (from KEGG)
Apoptosis - multiple species, organism-specific biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
Apoptosis - multiple species, conserved biosystem (from KEGG)
Apoptosis - multiple species, conserved biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
Apoptosis Modulation and Signaling, organism-specific biosystem (from WikiPathways)
Apoptosis Modulation and Signaling, organism-specific biosystemApoptosis, or cell death program, can be activated by various mechanisms within the extrinsic and the intrinsic pathway. While activation of cell death receptors leads to the engagement of the extrin...
DNA Damage Response (only ATM dependent), organism-specific biosystem (from WikiPathways)
DNA Damage Response (only ATM dependent), organism-specific biosystemThis is the second pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and TP53) which are connected with the first DNA damage response pathway. In...
Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
Direct p53 effectors, organism-specific biosystem
Direct p53 effectors
Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
Intrinsic Pathway for Apoptosis, organism-specific biosystemThe intrinsic (Bcl-2 inhibitable or mitochondrial) pathway of apoptosis functions in response to various types of intracellular stress including growth factor withdrawal, DNA damage, unfolding stress...
MicroRNAs in cancer, organism-specific biosystem (from KEGG)
MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
MicroRNAs in cancer, conserved biosystem (from KEGG)
MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
Nanomaterial induced apoptosis, organism-specific biosystem (from WikiPathways)
Nanomaterial induced apoptosis, organism-specific biosystemApotosis caused by nanomaterials, such as single-walled carbon nanohorns, titanium oxide, and polystyrene nanoparticles, may be induced through lysosomal impairment. For example, PAMAMs have been fou...
Photodynamic therapy-induced AP-1 survival signaling., organism-specific biosystem (from WikiPathways)
Photodynamic therapy-induced AP-1 survival signaling., organism-specific biosystemPhotodynamic therapy may induce an acute stress response mediated by mitogen-activated protein kinase kinase kinase 5 (MAP3K5), its downstream MAPKs that target c-Jun N-terminal kinase (JNK, MAPK8) a...
Photodynamic therapy-induced HIF-1 survival signaling, organism-specific biosystem (from WikiPathways)
Photodynamic therapy-induced HIF-1 survival signaling, organism-specific biosystemPhotodynamic therapy may induce a hypoxic survival response mediated by HIF-1.
Platinum drug resistance, organism-specific biosystem (from KEGG)
Platinum drug resistance, organism-specific biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...
Platinum drug resistance, conserved biosystem (from KEGG)
Platinum drug resistance, conserved biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...
Programmed Cell Death, organism-specific biosystem (from REACTOME)
Programmed Cell Death, organism-specific biosystemCell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number o...
Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
Regulation of Apoptosis by Parathyroid Hormone-related Protein, organism-specific biosystem (from WikiPathways)
Regulation of Apoptosis by Parathyroid Hormone-related Protein, organism-specific biosystemThis pathway is based on Figure 8 of "Parathyroid hormone-related protein regulates cell survival pathways via integrin alpha6beta4-mediated activation of phosphatidylinositol 3-kinase/Akt signaling....
Viral carcinogenesis, organism-specific biosystem (from KEGG)
Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
Viral carcinogenesis, conserved biosystem (from KEGG)
Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH64934 (e-PCR)
- UniSTS:89222

D11S4366 (e-PCR)
- UniSTS:38127

Homology

Homologs of the BAK1 gene: The BAK1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.
Orthologs from Annotation Pipeline: 199 organisms have orthologs with human gene BAK1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
BH domain binding	IEA Inferred from Electronic Annotation more info
chaperone binding	IEA Inferred from Electronic Annotation more info
heat shock protein binding	IEA Inferred from Electronic Annotation more info
identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
ion channel binding	IPI Inferred from Physical Interaction more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
molecular_function	ND No biological Data available more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
protein homodimerization activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
B cell apoptotic process	IEA Inferred from Electronic Annotation more info
B cell homeostasis	IEA Inferred from Electronic Annotation more info
B cell negative selection	IEA Inferred from Electronic Annotation more info
activation of cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	IEA Inferred from Electronic Annotation more info
aging	IEA Inferred from Electronic Annotation more info
animal organ regeneration	IEA Inferred from Electronic Annotation more info
apoptotic process	IDA Inferred from Direct Assay more info	PubMed
apoptotic process	NAS Non-traceable Author Statement more info	PubMed
apoptotic process involved in blood vessel morphogenesis	IEA Inferred from Electronic Annotation more info
apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
blood vessel remodeling	IEA Inferred from Electronic Annotation more info
brain development	IEA Inferred from Electronic Annotation more info
cell proliferation	IEA Inferred from Electronic Annotation more info
cellular response to UV	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to UV	ISS Inferred from Sequence or Structural Similarity more info
cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
cellular response to unfolded protein	TAS Traceable Author Statement more info	PubMed
endocrine pancreas development	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum calcium ion homeostasis	TAS Traceable Author Statement more info	PubMed
establishment or maintenance of transmembrane electrochemical gradient	IDA Inferred from Direct Assay more info	PubMed
extrinsic apoptotic signaling pathway in absence of ligand	IBA Inferred from Biological aspect of Ancestor more info	PubMed
fibroblast apoptotic process	IEA Inferred from Electronic Annotation more info
intrinsic apoptotic signaling pathway in response to DNA damage	IBA Inferred from Biological aspect of Ancestor more info	PubMed
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	TAS Traceable Author Statement more info	PubMed
limb morphogenesis	IEA Inferred from Electronic Annotation more info
mitochondrial fusion	IEA Inferred from Electronic Annotation more info
myeloid cell homeostasis	IEA Inferred from Electronic Annotation more info
negative regulation of cell proliferation	IEA Inferred from Electronic Annotation more info
negative regulation of endoplasmic reticulum calcium ion concentration	IEA Inferred from Electronic Annotation more info
negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
negative regulation of peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info
positive regulation of IRE1-mediated unfolded protein response	TAS Traceable Author Statement more info	PubMed
positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of calcium ion transport into cytosol	IEA Inferred from Electronic Annotation more info
positive regulation of endoplasmic reticulum unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	TAS Traceable Author Statement more info
positive regulation of proteolysis	IDA Inferred from Direct Assay more info	PubMed
positive regulation of release of cytochrome c from mitochondria	IEA Inferred from Electronic Annotation more info
post-embryonic camera-type eye morphogenesis	IEA Inferred from Electronic Annotation more info
regulation of cell cycle	IEA Inferred from Electronic Annotation more info
regulation of mitochondrial membrane permeability	IDA Inferred from Direct Assay more info	PubMed
regulation of mitochondrial membrane potential	IDA Inferred from Direct Assay more info	PubMed
regulation of protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
regulation of protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
release of cytochrome c from mitochondria	IDA Inferred from Direct Assay more info	PubMed
release of cytochrome c from mitochondria	IGI Inferred from Genetic Interaction more info	PubMed
response to UV-C	IEA Inferred from Electronic Annotation more info
response to ethanol	IEA Inferred from Electronic Annotation more info
response to fungus	IEA Inferred from Electronic Annotation more info
response to gamma radiation	IEA Inferred from Electronic Annotation more info
response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
response to mycotoxin	IEA Inferred from Electronic Annotation more info
response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
thymocyte apoptotic process	IEA Inferred from Electronic Annotation more info
vagina development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
BAK complex	IDA Inferred from Direct Assay more info	PubMed
cytosol	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
integral component of mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
mitochondrial outer membrane	TAS Traceable Author Statement more info
mitochondrion	IDA Inferred from Direct Assay more info	PubMed
pore complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: bcl-2 homologous antagonist/killer

Names: BCL2-like 7 protein; apoptosis regulator BAK; bcl-2-like protein 7; bcl2-L-7; pro-apoptotic protein BAK

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001188.4 → NP_001179.1 bcl-2 homologous antagonist/killer

See identical proteins and their annotated locations for NP_001179.1

Status: REVIEWED

Source sequence(s)

BC004431, BM855203, CB142221, Z93017

Consensus CDS

CCDS4781.1

UniProtKB/Swiss-Prot

Q16611

UniProtKB/TrEMBL

A0A0S2Z391

Related

ENSP00000363591.3, ENST00000374467.3

Conserved Domains (1) summary

cd06845
Location:29 → 183

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p12 Primary Assembly

Range

33572546..33580296 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011514779.3 → XP_011513081.1 bcl-2 homologous antagonist/killer isoform X1

See identical proteins and their annotated locations for XP_011513081.1

UniProtKB/Swiss-Prot

Q16611

UniProtKB/TrEMBL

A0A0S2Z391

Conserved Domains (1) summary

cd06845
Location:29 → 183

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
XM_011514780.1 → XP_011513082.1 bcl-2 homologous antagonist/killer isoform X2

See identical proteins and their annotated locations for XP_011513082.1

Conserved Domains (1) summary

cd06845
Location:2 → 124

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...