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Bak1 BCL2-antagonist/killer 1 [ Mus musculus (house mouse) ]

Gene ID: 12018, updated on 5-Jul-2025
Official Symbol
Bak1provided by MGI
Official Full Name
BCL2-antagonist/killer 1provided by MGI
Primary source
MGI:MGI:1097161
See related
Ensembl:ENSMUSG00000057789 AllianceGenome:MGI:1097161
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bak; N-Bak; N-BAK1
Summary
Enables identical protein binding activity. Involved in cellular response to UV; positive regulation of apoptotic process; and release of cytochrome c from mitochondria. Acts upstream of or within several processes, including apoptotic process involved in blood vessel morphogenesis; apoptotic signaling pathway; and lymphocyte apoptotic process. Located in cytosol; endoplasmic reticulum; and mitochondrial outer membrane. Part of BAK complex. Is expressed in several structures, including alimentary system; brain; branchial arch; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in ataxia telangiectasia and cervix carcinoma. Orthologous to human BAK1 (BCL2 antagonist/killer 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Broad expression in large intestine adult (RPKM 109.5), duodenum adult (RPKM 107.1) and 25 other tissues See more
Orthologs
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See Bak1 in Genome Data Viewer
Location:
17 A3.3; 17 13.65 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (27238786..27247601, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (27019812..27028627, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene synaptic Ras GTPase activating protein 1 homolog (rat) Neighboring gene microRNA 3083b Neighboring gene microRNA 3083 Neighboring gene STARR-positive B cell enhancer ABC_E7502 Neighboring gene zinc finger and BTB domain containing 9 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27137073-27137182 Neighboring gene STARR-positive B cell enhancer ABC_E11633 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27164461-27164644 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27165231-27165340 Neighboring gene gametogenetin binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_42142 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27193173-27193441 Neighboring gene inositol 1,4,5-triphosphate receptor 3 Neighboring gene microRNA 7677 Neighboring gene inositol 1,4,5-triphosphate receptor 3, opposite strand

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables BH domain binding IEA
Inferred from Electronic Annotation
more info
 
enables BH domain binding ISO
Inferred from Sequence Orthology
more info
 
enables channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heat shock protein binding IEA
Inferred from Electronic Annotation
more info
 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables porin activity IEA
Inferred from Electronic Annotation
more info
 
enables porin activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-folding chaperone binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within B cell homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within B cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within B cell negative selection IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in animal organ regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process involved in blood vessel morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blood vessel remodeling IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of calcium ion transport into cytosol IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to UV IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to UV IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in endocrine pancreas development IEA
Inferred from Electronic Annotation
more info
 
involved_in endoplasmic reticulum calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of establishment of localization in cell IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in establishment or maintenance of transmembrane electrochemical gradient IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment or maintenance of transmembrane electrochemical gradient ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment or maintenance of transmembrane electrochemical gradient ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in extrinsic apoptotic signaling pathway in absence of ligand IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within fibroblast apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within homeostasis of number of cells IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within leukocyte homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within limb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within mitochondrial fusion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within myeloid cell homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of endoplasmic reticulum calcium ion concentration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of release of cytochrome c from mitochondria IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of peptidyl-serine phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of calcium ion transport into cytosol IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of release of cytochrome c from mitochondria IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of release of cytochrome c from mitochondria NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within post-embryonic camera-type eye morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of biological quality IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of mitochondrial membrane permeability IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mitochondrial membrane permeability ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitochondrial membrane permeability ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of mitochondrial membrane potential IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitochondrial membrane potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transport IEA
Inferred from Electronic Annotation
more info
 
involved_in release of cytochrome c from mitochondria IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in release of cytochrome c from mitochondria IEA
Inferred from Electronic Annotation
more info
 
involved_in release of cytochrome c from mitochondria IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
involved_in release of cytochrome c from mitochondria ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to UV-C IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to fungus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to gamma radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to mycotoxin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within thymocyte apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within vagina development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of BAK complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of BAK complex IEA
Inferred from Electronic Annotation
more info
 
part_of BAK complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of BAK complex ISO
Inferred from Sequence Orthology
more info
 
part_of Bcl-2 family protein complex IEA
Inferred from Electronic Annotation
more info
 
part_of Bcl-2 family protein complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of pore complex IEA
Inferred from Electronic Annotation
more info
 
part_of pore complex ISO
Inferred from Sequence Orthology
more info
 
part_of pore complex ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
bcl-2 homologous antagonist/killer
Names
Bcl2 homologous antagonist/killer
apoptosis regulator BAK

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007523.3NP_031549.2  bcl-2 homologous antagonist/killer

    See identical proteins and their annotated locations for NP_031549.2

    Status: VALIDATED

    Source sequence(s)
    AC132404, AW045927, BC057589, BY197389, CX564692
    Consensus CDS
    CCDS28558.1
    UniProtKB/Swiss-Prot
    E9QM21, O08734, Q8C264
    Related
    ENSMUSP00000077757.6, ENSMUST00000078691.12
    Conserved Domains (1) summary
    cd06845
    Location:27181
    Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

RNA

  1. NR_149749.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC132404, AW045927, BC057589, BY197389
    Related
    ENSMUST00000025034.12

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    27238786..27247601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)