Bin3 bridging integrator 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bin3provided by MGI
Official Full Name: bridging integrator 3provided by MGI
Primary source: MGI:MGI:1929883
See related: Ensembl:ENSMUSG00000022089 AllianceGenome:MGI:1929883
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700015F07Rik
Summary: Predicted to contribute to lipid binding activity. Acts upstream of or within myoblast migration involved in skeletal muscle regeneration; regulation of lamellipodium assembly; and skeletal muscle fiber development. Located in actin cytoskeleton. Is expressed in 1st branchial arch mandibular component; 1st branchial arch maxillary component; embryo; limb; and testis. Orthologous to human BIN3 (bridging integrator 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 5.9), liver E14 (RPKM 5.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14; 14 D2

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (70337538..70375413)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (70100089..70137964)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bin3 forms a complex with Rac1 and Cdc42, Rho GTPases involved in actin polymerization, which are known to be essential for myotube formation.
Title: The N-BAR domain protein, Bin3, regulates Rac1- and Cdc42-dependent processes in myogenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Bin3 (e-PCR), detects polymorphism
- UniSTS:508362

Homology

Homologs of the Bin3 gene: The Bin3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, zebrafish, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and frog.
Orthologs from Annotation Pipeline: 489 organisms have orthologs with human gene Bin3
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to lipid binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cortical patch localization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within division septum assembly	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within myoblast migration involved in skeletal muscle regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane tubulation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle fiber development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in unidimensional cell growth	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bridging integrator 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360404.1 → NP_001347333.1 bridging integrator 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC151836, AI464318, AK005992, BB682940, CA562064, CX565660

Conserved Domains (1) summary

cl12013
Location:1 → 192

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
NM_021328.4 → NP_067303.1 bridging integrator 3 isoform 1

See identical proteins and their annotated locations for NP_067303.1

Status: VALIDATED

Source sequence(s)

AC151836, AI464318, AK005992, BB682940, CA562064

Consensus CDS

CCDS27247.1

UniProtKB/Swiss-Prot

Q9JI08

UniProtKB/TrEMBL

A0A8C6IGS0

Related

ENSMUSP00000022680.8, ENSMUST00000022680.9

Conserved Domains (1) summary

cd07590
Location:12 → 236

BAR_Bin3; The Bin/Amphiphysin/Rvs (BAR) domain of Bridging integrator 3

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

70337538..70375413

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006519330.4 → XP_006519393.1 bridging integrator 3 isoform X1

Conserved Domains (1) summary

cd07590
Location:12 → 209

BAR_Bin3; The Bin/Amphiphysin/Rvs (BAR) domain of Bridging integrator 3
XM_030247901.1 → XP_030103761.1 bridging integrator 3 isoform X3

Conserved Domains (1) summary

cl12013
Location:1 → 114

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_006519332.4 → XP_006519395.1 bridging integrator 3 isoform X2

See identical proteins and their annotated locations for XP_006519395.1

Conserved Domains (1) summary

cl12013
Location:1 → 192

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_030247902.1 → XP_030103762.1 bridging integrator 3 isoform X3

Conserved Domains (1) summary

cl12013
Location:1 → 114

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_036158770.1 → XP_036014663.1 bridging integrator 3 isoform X2

Conserved Domains (1) summary

cl12013
Location:1 → 192

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_036158771.1 → XP_036014664.1 bridging integrator 3 isoform X2

Conserved Domains (1) summary

cl12013
Location:1 → 192

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_011245124.2 → XP_011243426.1 bridging integrator 3 isoform X3

Conserved Domains (1) summary

cl12013
Location:1 → 114

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature