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Bin3 bridging integrator 3 [ Mus musculus (house mouse) ]

Gene ID: 57784, updated on 2-Nov-2024

Summary

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Official Symbol
Bin3provided by MGI
Official Full Name
bridging integrator 3provided by MGI
Primary source
MGI:MGI:1929883
See related
Ensembl:ENSMUSG00000022089 AllianceGenome:MGI:1929883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700015F07Rik
Summary
Predicted to contribute to lipid binding activity. Acts upstream of or within myoblast migration involved in skeletal muscle regeneration; regulation of lamellipodium assembly; and skeletal muscle fiber development. Located in actin cytoskeleton. Is expressed in several structures, including 1st branchial arch; lens; limb; and testis. Orthologous to human BIN3 (bridging integrator 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 5.9), liver E14 (RPKM 5.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Bin3 in Genome Data Viewer
Location:
14 D2; 14 36.21 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70337538..70375413)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (70100089..70137964)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene phosphatidylethanolamine binding protein 4 Neighboring gene predicted gene, 33524 Neighboring gene STARR-seq mESC enhancer starr_37072 Neighboring gene STARR-positive B cell enhancer mm9_chr14:70468715-70469016 Neighboring gene STARR-positive B cell enhancer mm9_chr14:70469146-70469446 Neighboring gene STARR-positive B cell enhancer ABC_E8569 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:70499772-70499955 Neighboring gene early growth response 3 Neighboring gene RIKEN cDNA 9930012K11 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:70553578-70553761 Neighboring gene cell cycle activator and apoptosis regulator 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Bin3 deletion causes cataracts and increased susceptibility to lymphoma during aging. Ramalingam A, et al. Cancer Res, 2008 Mar 15. PMID 18339847
  2. The N-BAR domain protein, Bin3, regulates Rac1- and Cdc42-dependent processes in myogenesis. Simionescu-Bankston A, et al. Dev Biol, 2013 Oct 1. PMID 23872330, Free PMC Article
  3. Human BIN3 complements the F-actin localization defects caused by loss of Hob3p, the fission yeast homolog of Rvs161p. Routhier EL, et al. J Biol Chem, 2001 Jun 15. PMID 11274158
  4. A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. Xue W, et al. Proc Natl Acad Sci U S A, 2012 May 22. PMID 22566646, Free PMC Article
  5. A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects. Choquet H, et al. Nat Commun, 2021 Jun 14. PMID 34127677, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to lipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin cortical patch localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cortical patch localization IEA
Inferred from Electronic Annotation
more info
  
involved_in division septum assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within myoblast migration involved in skeletal muscle regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in plasma membrane tubulation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skeletal muscle fiber development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skeletal muscle tissue regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in unidimensional cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in unidimensional cell growth ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
bridging integrator 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360404.1 → NP_001347333.1  bridging integrator 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC151836, AI464318, AK005992, BB682940, CA562064, CX565660
    UniProtKB/TrEMBL
    Q3TC47
    Conserved Domains (1) summary
    cl12013
    Location:1 → 192
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. NM_021328.4 → NP_067303.1  bridging integrator 3 isoform 1

    See identical proteins and their annotated locations for NP_067303.1

    Status: VALIDATED

    Source sequence(s)
    AC151836, AI464318, AK005992, BB682940, CA562064
    Consensus CDS
    CCDS27247.1
    UniProtKB/Swiss-Prot
    Q9JI08
    UniProtKB/TrEMBL
    Q3TC47
    Related
    ENSMUSP00000022680.8, ENSMUST00000022680.9
    Conserved Domains (1) summary
    cd07590
    Location:12 → 236
    BAR_Bin3; The Bin/Amphiphysin/Rvs (BAR) domain of Bridging integrator 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    70337538..70375413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519330.4 → XP_006519393.1  bridging integrator 3 isoform X1

    UniProtKB/TrEMBL
    Q3TC47
    Conserved Domains (1) summary
    cd07590
    Location:12 → 209
    BAR_Bin3; The Bin/Amphiphysin/Rvs (BAR) domain of Bridging integrator 3

  2. XM_030247901.1 → XP_030103761.1  bridging integrator 3 isoform X3

    Conserved Domains (1) summary
    cl12013
    Location:1 → 114
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. XM_006519332.4 → XP_006519395.1  bridging integrator 3 isoform X2

    See identical proteins and their annotated locations for XP_006519395.1

    UniProtKB/TrEMBL
    Q3TC47
    Conserved Domains (1) summary
    cl12013
    Location:1 → 192
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  4. XM_030247902.1 → XP_030103762.1  bridging integrator 3 isoform X3

    Conserved Domains (1) summary
    cl12013
    Location:1 → 114
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  5. XM_036158770.1 → XP_036014663.1  bridging integrator 3 isoform X2

    UniProtKB/TrEMBL
    Q3TC47
    Conserved Domains (1) summary
    cl12013
    Location:1 → 192
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  6. XM_036158771.1 → XP_036014664.1  bridging integrator 3 isoform X2

    UniProtKB/TrEMBL
    Q3TC47
    Conserved Domains (1) summary
    cl12013
    Location:1 → 192
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  7. XM_011245124.2 → XP_011243426.1  bridging integrator 3 isoform X3

    Conserved Domains (1) summary
    cl12013
    Location:1 → 114
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JI08.1 GenPept UniProtKB/Swiss-Prot:Q9JI08

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