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BIN3 bridging integrator 3 [ Homo sapiens (human) ]

Gene ID: 55909, updated on 21-Dec-2019

Summary

Official Symbol
BIN3provided by HGNC
Official Full Name
bridging integrator 3provided by HGNC
Primary source
HGNC:HGNC:1054
See related
Ensembl:ENSG00000147439 MIM:606396
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The product of this gene is a member of the BAR domain protein family. The encoded protein is comprised solely of a BAR domain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 13.5), adrenal (RPKM 7.2) and 25 other tissues See more
Orthologs

Genomic context

See BIN3 in Genome Data Viewer
Location:
8p21.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (22620418..22669148, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (22477931..22526661, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene PDZ and LIM domain 2 Neighboring gene uncharacterized LOC107986876 Neighboring gene chromosome 8 open reading frame 58 Neighboring gene cell cycle and apoptosis regulator 2 Neighboring gene BIN3 intronic transcript 1 Neighboring gene uncharacterized LOC105369180 Neighboring gene CRISPRi-validated cis-regulatory element chr8.740 Neighboring gene uncharacterized LOC107986924 Neighboring gene early growth response 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC14978

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytoskeletal adaptor activity NAS
Non-traceable Author Statement
more info
PubMed 
cytoskeletal protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to lipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin cortical patch localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament organization NAS
Non-traceable Author Statement
more info
PubMed 
cytoskeleton-dependent cytokinesis NAS
Non-traceable Author Statement
more info
PubMed 
division septum assembly IEA
Inferred from Electronic Annotation
more info
 
endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
myoblast migration involved in skeletal muscle regeneration IEA
Inferred from Electronic Annotation
more info
 
plasma membrane tubulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of lamellipodium assembly IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle fiber development IEA
Inferred from Electronic Annotation
more info
 
unidimensional cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
actin cortical patch IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363046.1NP_001349975.1  bridging integrator 3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    BC009824, BM670487, CN427936, DA480525
    Consensus CDS
    CCDS87587.1
    Related
    ENSP00000382859.4, ENST00000399977.8
    Conserved Domains (1) summary
    cl12013
    Location:7188
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. NM_018688.6NP_061158.1  bridging integrator 3 isoform 1

    See identical proteins and their annotated locations for NP_061158.1

    Status: REVIEWED

    Source sequence(s)
    AC037459, AC105046, BC009824, BM670487, DA480525
    Consensus CDS
    CCDS47825.1
    UniProtKB/Swiss-Prot
    Q9NQY0
    Related
    ENSP00000276416.6, ENST00000276416.11
    Conserved Domains (1) summary
    cd07590
    Location:12236
    BAR_Bin3; The Bin/Amphiphysin/Rvs (BAR) domain of Bridging integrator 3

RNA

  1. NR_156436.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC037459, AC105046, BC009824, BM670487, CR995147, DA480525

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    22620418..22669148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544586.2XP_011542888.1  bridging integrator 3 isoform X2

    See identical proteins and their annotated locations for XP_011542888.1

    UniProtKB/Swiss-Prot
    Q9NQY0
    Related
    ENSP00000430423.1, ENST00000519513.5
    Conserved Domains (1) summary
    cl12013
    Location:1182
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. XM_011544587.1XP_011542889.1  bridging integrator 3 isoform X3

    UniProtKB/TrEMBL
    E5RHU4
    Related
    ENSP00000429660.1, ENST00000520292.1
    Conserved Domains (1) summary
    cl12013
    Location:12118
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
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