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RDH14 retinol dehydrogenase 14 [ Homo sapiens (human) ]

Gene ID: 57665, updated on 7-Aug-2022

Summary

Official Symbol
RDH14provided by HGNC
Official Full Name
retinol dehydrogenase 14provided by HGNC
Primary source
HGNC:HGNC:19979
See related
Ensembl:ENSG00000240857 MIM:616796; AllianceGenome:HGNC:19979
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAN2; SDR7C4
Summary
Enables NADP-retinol dehydrogenase activity. Involved in osteoblast differentiation. Located in cytosol; endoplasmic reticulum; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart (RPKM 13.2), prostate (RPKM 10.6) and 25 other tissues See more
Orthologs
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Genomic context

See RDH14 in Genome Data Viewer
Location:
2p24.2
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (18554723..18560653, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (18586834..18592767, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (18735989..18741919, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373454 Neighboring gene Sharpr-MPRA regulatory region 12735 Neighboring gene NT5C1B-RDH14 readthrough Neighboring gene uncharacterized LOC105373456 Neighboring gene RNA, U6 small nuclear 1215, pseudogene Neighboring gene 5'-nucleotidase, cytosolic IB Neighboring gene Sharpr-MPRA regulatory region 8729

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough NT5C1B-RDH14

Readthrough gene: NT5C1B-RDH14, Included gene: NT5C1B

Homology

General protein information

Preferred Names
retinol dehydrogenase 14
Names
alcohol dehydrogenase PAN2
pancreas protein 2
retinol dehydrogenase 14 (all-trans and 9-cis)
retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
short chain dehydrogenase/reductase family 7C member 4
NP_065956.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020905.4NP_065956.1  retinol dehydrogenase 14

    See identical proteins and their annotated locations for NP_065956.1

    Status: VALIDATED

    Source sequence(s)
    AK314994, AY358511, CD676669
    Consensus CDS
    CCDS1693.1
    UniProtKB/Swiss-Prot
    Q9HBH5
    UniProtKB/TrEMBL
    Q53RX3
    Related
    ENSP00000370648.3, ENST00000381249.4
    Conserved Domains (1) summary
    cd09807
    Location:43328
    retinol-DH_like_SDR_c; retinol dehydrogenases (retinol-DHs), classical (c) SDRs

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    18554723..18560653 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    18586834..18592767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)