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NT5C1B-RDH14 NT5C1B-RDH14 readthrough [ Homo sapiens (human) ]

Gene ID: 100526794, updated on 13-May-2022

Summary

Official Symbol
NT5C1B-RDH14provided by HGNC
Official Full Name
NT5C1B-RDH14 readthroughprovided by HGNC
Primary source
HGNC:HGNC:38831
See related
Ensembl:ENSG00000250741 AllianceGenome:HGNC:38831
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIRP; cN1B; cN-IB; NT5C1B
Summary
This locus represents naturally occurring read-through transcription between the neighboring NT5C1B (5'-nucleotidase, cytosolic IB) and RDH14 (retinol dehydrogenase 14) genes on chromosome 2. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. [provided by RefSeq, Nov 2010]
Expression
Broad expression in testis (RPKM 22.8), heart (RPKM 7.0) and 24 other tissues See more
Orthologs
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Genomic context

See NT5C1B-RDH14 in Genome Data Viewer
Location:
2p24.2
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (18554723..18589569, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (18586834..18621687, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (18735989..18770835, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373454 Neighboring gene Sharpr-MPRA regulatory region 12735 Neighboring gene uncharacterized LOC105373456 Neighboring gene RNA, U6 small nuclear 1215, pseudogene Neighboring gene 5'-nucleotidase, cytosolic IB Neighboring gene retinol dehydrogenase 14 Neighboring gene Sharpr-MPRA regulatory region 8729 Neighboring gene long intergenic non-protein coding RNA 1376

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • FLJ32882, FLJ97601

General protein information

Preferred Names
NT5C1B-RDH14 protein
Names
Cytosolic 5'-nucleotidase 1B
Cytosolic 5'-nucleotidase IB
NT5C1B-RDH14 read-through transcript
NP_001186032.1
NP_001186033.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199103.2NP_001186032.1  NT5C1B-RDH14 protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1), which is a fusion protein sharing sequence identity with each individual gene product.
    Source sequence(s)
    AC079148, AK307653
    Related
    ENSP00000412639.2, ENST00000444297.2
    Conserved Domains (2) summary
    pfam06189
    Location:279445
    5-nucleotidase; 5'-nucleotidase
    cl21454
    Location:445642
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_001199104.2NP_001186033.1  NT5C1B-RDH14 protein isoform 2

    See identical proteins and their annotated locations for NP_001186033.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an additional in-frame exon in the 5' coding region, an alternate in-frame splice site in the central coding region, and an additional exon that causes a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, and it lacks sequence identity with the RDH14 product, compared to isoform 1.
    Source sequence(s)
    AC079148, AK057444
    UniProtKB/Swiss-Prot
    Q96P26
    Related
    ENSP00000433415.1, ENST00000532967.5
    Conserved Domains (1) summary
    pfam06189
    Location:337595
    5-nucleotidase; 5'-nucleotidase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    18554723..18589569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    18586834..18621687 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)