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NT5C1B 5'-nucleotidase, cytosolic IB [ Homo sapiens (human) ]

Gene ID: 93034, updated on 23-Nov-2021

Summary

Official Symbol
NT5C1Bprovided by HGNC
Official Full Name
5'-nucleotidase, cytosolic IBprovided by HGNC
Primary source
HGNC:HGNC:17818
See related
Ensembl:ENSG00000185013 MIM:610526
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIRP; CN1B; CN-IB
Summary
Cytosolic 5-prime nucleotidases, such as NT5C1B, catalyze production of adenosine, which regulates diverse physiologic processes (Sala-Newby and Newby, 2001 [PubMed 11690631]).[supplied by OMIM, Mar 2008]
Expression
Restricted expression toward testis (RPKM 23.0) See more
Orthologs
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Genomic context

See NT5C1B in Genome Data Viewer
Location:
2p24.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (18562871..18589569, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (18744137..18770835, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12735 Neighboring gene NT5C1B-RDH14 readthrough Neighboring gene uncharacterized LOC105373456 Neighboring gene RNA, U6 small nuclear 1215, pseudogene Neighboring gene retinol dehydrogenase 14 Neighboring gene Sharpr-MPRA regulatory region 8729 Neighboring gene long intergenic non-protein coding RNA 1376

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough NT5C1B-RDH14

Readthrough gene: NT5C1B-RDH14, Included gene: RDH14

Homology

Clone Names

  • MGC26640

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 5'-nucleotidase activity TAS
Traceable Author Statement
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in adenosine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in purine nucleotide catabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleus HDA PubMed 

General protein information

Preferred Names
cytosolic 5'-nucleotidase 1B
Names
autoimmune infertility-related protein
testicular tissue protein Li 1
NP_001002006.1
NP_001186015.1
NP_001186016.1
NP_001186017.1
NP_150278.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002006.3NP_001002006.1  cytosolic 5'-nucleotidase 1B isoform 1

    See identical proteins and their annotated locations for NP_001002006.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AA774429, AA974253, AF417165, BC136387, DB054653
    Consensus CDS
    CCDS33150.1
    UniProtKB/Swiss-Prot
    Q96P26
    UniProtKB/TrEMBL
    A0A140VJC7
    Related
    ENSP00000352904.2, ENST00000359846.6
    Conserved Domains (1) summary
    pfam06189
    Location:337595
    5-nucleotidase; 5'-nucleotidase
  2. NM_001199086.2NP_001186015.1  cytosolic 5'-nucleotidase 1B isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AA774429, AA974253, AK302200, BC136387, DB054653
    UniProtKB/Swiss-Prot
    Q96P26
    UniProtKB/TrEMBL
    B4DXZ9
    Conserved Domains (1) summary
    pfam06189
    Location:320578
    5-nucleotidase; 5'-nucleotidase
  3. NM_001199087.2NP_001186016.1  cytosolic 5'-nucleotidase 1B isoform 4

    See identical proteins and their annotated locations for NP_001186016.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (4) that is longer than isoform 1.
    Source sequence(s)
    AA774429, AA974253, AK302795, BC136387, DB054653
    UniProtKB/Swiss-Prot
    Q96P26
    UniProtKB/TrEMBL
    B4DZ86
    Conserved Domains (1) summary
    pfam06189
    Location:354612
    5-nucleotidase; 5'-nucleotidase
  4. NM_001199088.2NP_001186017.1  cytosolic 5'-nucleotidase 1B isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (5) that is longer than isoform 1.
    Source sequence(s)
    AA774429, AA974253, BC136387, BC141842, DB054653
    UniProtKB/Swiss-Prot
    Q96P26
    Conserved Domains (1) summary
    pfam06189
    Location:339597
    5-nucleotidase; 5'-nucleotidase
  5. NM_033253.4NP_150278.2  cytosolic 5'-nucleotidase 1B isoform 2

    See identical proteins and their annotated locations for NP_150278.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AA774429, AA974253, AK097422, BC136387
    Consensus CDS
    CCDS33149.1
    UniProtKB/Swiss-Prot
    Q96P26
    UniProtKB/TrEMBL
    B3KUK6
    Related
    ENSP00000305979.4, ENST00000304081.8
    Conserved Domains (1) summary
    pfam06189
    Location:277535
    5-nucleotidase; 5'-nucleotidase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    18562871..18589569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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