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ZBTB4 zinc finger and BTB domain containing 4 [ Homo sapiens (human) ]

Gene ID: 57659, updated on 11-Jun-2021

Summary

Official Symbol
ZBTB4provided by HGNC
Official Full Name
zinc finger and BTB domain containing 4provided by HGNC
Primary source
HGNC:HGNC:23847
See related
Ensembl:ENSG00000174282 MIM:612308
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF903; KAISO-L1
Expression
Ubiquitous expression in ovary (RPKM 24.8), thyroid (RPKM 20.6) and 25 other tissues See more
Orthologs
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Genomic context

See ZBTB4 in Genome Data Viewer
Location:
17p13.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (7459366..7484249, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7362697..7387568, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 11 Neighboring gene cholinergic receptor nicotinic beta 1 subunit Neighboring gene solute carrier family 35 member G6 Neighboring gene RNA polymerase II subunit A Neighboring gene TNFSF12-TNFSF13 readthrough Neighboring gene TNF superfamily member 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1538

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 4
Names
KAISO-like zinc finger protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128833.2NP_001122305.1  zinc finger and BTB domain-containing protein 4

    See identical proteins and their annotated locations for NP_001122305.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an altenate 5' UTR, as compared to variant 1.
    Source sequence(s)
    AC113189
    Consensus CDS
    CCDS11107.1
    UniProtKB/Swiss-Prot
    Q9P1Z0
    Related
    ENSP00000369973.4, ENST00000380599.9
    Conserved Domains (5) summary
    smart00225
    Location:3162
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:311331
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:2062
    BTB; BTB/POZ domain
    pfam13465
    Location:323347
    zf-H2C2_2; Zinc-finger double domain
    pfam13913
    Location:235257
    zf-C2HC_2; zinc-finger of a C2HC-type
  2. NM_020899.4NP_065950.2  zinc finger and BTB domain-containing protein 4

    See identical proteins and their annotated locations for NP_065950.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    AC113189
    Consensus CDS
    CCDS11107.1
    UniProtKB/Swiss-Prot
    Q9P1Z0
    UniProtKB/TrEMBL
    B3KVD4
    Related
    ENSP00000307858.4, ENST00000311403.4
    Conserved Domains (5) summary
    smart00225
    Location:3162
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:311331
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:2062
    BTB; BTB/POZ domain
    pfam13465
    Location:323347
    zf-H2C2_2; Zinc-finger double domain
    pfam13913
    Location:235257
    zf-C2HC_2; zinc-finger of a C2HC-type

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    7459366..7484249 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721564.2XP_006721627.1  zinc finger and BTB domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006721627.1

    UniProtKB/Swiss-Prot
    Q9P1Z0
    Conserved Domains (5) summary
    smart00225
    Location:3162
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:311331
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:2062
    BTB; BTB/POZ domain
    pfam13465
    Location:323347
    zf-H2C2_2; Zinc-finger double domain
    pfam13913
    Location:235257
    zf-C2HC_2; zinc-finger of a C2HC-type
  2. XM_006721563.3XP_006721626.1  zinc finger and BTB domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006721626.1

    UniProtKB/Swiss-Prot
    Q9P1Z0
    Conserved Domains (5) summary
    smart00225
    Location:3162
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:311331
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:2062
    BTB; BTB/POZ domain
    pfam13465
    Location:323347
    zf-H2C2_2; Zinc-finger double domain
    pfam13913
    Location:235257
    zf-C2HC_2; zinc-finger of a C2HC-type
  3. XM_011523972.2XP_011522274.1  zinc finger and BTB domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011522274.1

    UniProtKB/Swiss-Prot
    Q9P1Z0
    Conserved Domains (5) summary
    smart00225
    Location:3162
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:311331
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:2062
    BTB; BTB/POZ domain
    pfam13465
    Location:323347
    zf-H2C2_2; Zinc-finger double domain
    pfam13913
    Location:235257
    zf-C2HC_2; zinc-finger of a C2HC-type

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_016107299.1 Reference GRCh38.p13 PATCHES

    Range
    79835..104706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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