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SH3RF1 SH3 domain containing ring finger 1 [ Homo sapiens (human) ]

Gene ID: 57630, updated on 5-Apr-2020

Summary

Official Symbol
SH3RF1provided by HGNC
Official Full Name
SH3 domain containing ring finger 1provided by HGNC
Primary source
HGNC:HGNC:17650
See related
Ensembl:ENSG00000154447 MIM:618642
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
POSH; RNF142; SH3MD2
Summary
This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 11.9), stomach (RPKM 11.2) and 24 other tissues See more
Orthologs

Genomic context

See SH3RF1 in Genome Data Viewer
Location:
4q32.3-q33
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (169094259..169270956, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (170015407..170192249, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene carbonyl reductase 4 Neighboring gene RNY4 pseudogene 17 Neighboring gene uncharacterized LOC105377527 Neighboring gene ribosomal protein L6 pseudogene 12 Neighboring gene uncharacterized LOC105377529 Neighboring gene NIMA related kinase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag ALIX is an ubiquitination substrate of the ubiquitin E3-ligase POSH and POSH and ALIX cooperate to facilitate efficient HIV-1 release, suggesting the interaction between HIV-1 Gag and POSH and POSH may be functionally auxiliary for viral release PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21602, KIAA1494

Gene Ontology Provided by GOA

Function Evidence Code Pubs
MAP-kinase scaffold activity ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autoubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of CD4-positive, alpha-beta T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of CD8-positive, alpha-beta T cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase SH3RF1
Names
RING-type E3 ubiquitin transferase SH3RF1
SH3 domain-containing RING finger protein 1
SH3 multiple domains 2
SH3 multiple domains protein 2
plenty of SH3 domains
plenty of SH3s
putative E3 ubiquitin-protein ligase SH3RF1
ring finger protein 142
NP_065921.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020870.4NP_065921.2  E3 ubiquitin-protein ligase SH3RF1

    See identical proteins and their annotated locations for NP_065921.2

    Status: REVIEWED

    Source sequence(s)
    AC021151, AC096741, AC104783
    Consensus CDS
    CCDS34099.1
    UniProtKB/Swiss-Prot
    Q7Z6J0
    Related
    ENSP00000284637.9, ENST00000284637.14
    Conserved Domains (5) summary
    cd11785
    Location:833887
    SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
    cd11926
    Location:449503
    SH3_SH3RF1_3; Third Src Homology 3 domain of SH3 domain containing ring finger 1, an E3 ubiquitin-protein ligase
    cd11930
    Location:200254
    SH3_SH3RF1_2; Second Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase
    cd00162
    Location:1156
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl17036
    Location:137190
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    169094259..169270956 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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