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TRMT9B tRNA methyltransferase 9B (putative) [ Homo sapiens (human) ]

Gene ID: 57604, updated on 23-Nov-2021

Summary

Official Symbol
TRMT9Bprovided by HGNC
Official Full Name
tRNA methyltransferase 9B (putative)provided by HGNC
Primary source
HGNC:HGNC:26725
See related
Ensembl:ENSG00000250305 MIM:615666
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRM9L; hTRM9L; C8orf79; KIAA1456
Expression
Biased expression in thyroid (RPKM 9.8), brain (RPKM 1.5) and 7 other tissues See more
Orthologs
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Genomic context

See TRMT9B in Genome Data Viewer
Location:
8p22
Exon count:
12
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (12945673..13029777)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (12803182..12887286)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC340357 Neighboring gene long intergenic non-protein coding RNA 681 Neighboring gene uncharacterized LOC105379289 Neighboring gene regulator of solute carriers 1 pseudogene Neighboring gene RNA, U6 small nuclear 842, pseudogene Neighboring gene DLC1 Rho GTPase activating protein Neighboring gene uncharacterized LOC101930149 Neighboring gene MT-ND4 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of clinical symptoms of dissociation in a trauma-exposed sample.
GeneReviews: Not available
Genome-wide diet-gene interaction analyses for risk of colorectal cancer.
GeneReviews: Not available
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36980, KIAA1456, MGC43113

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables tRNA (uracil) methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tRNA methyltransferase activity EXP
Inferred from Experiment
more info
PubMed 
Process Evidence Code Pubs
involved_in tRNA methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA modification TAS
Traceable Author Statement
more info
 
involved_in tRNA wobble uridine modification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable tRNA methyltransferase 9B
Names
probable tRNA methyltransferase 9-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099677.1NP_001093147.1  probable tRNA methyltransferase 9B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the presence and absence of exons at its 5' end, compared to variant 1. These differences produce a unique 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AC135352, AK125638, AW295329, DR001645
  2. NM_020844.3NP_065895.2  probable tRNA methyltransferase 9B isoform 1

    See identical proteins and their annotated locations for NP_065895.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB040889, AC135352, AW295329, DA390356, DC334299
    Consensus CDS
    CCDS47808.1
    UniProtKB/Swiss-Prot
    Q9P272
    Related
    ENSP00000432695.1, ENST00000524591.7
    Conserved Domains (1) summary
    pfam13649
    Location:48135
    Methyltransf_25; Methyltransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    12945673..13029777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544601.3XP_011542903.1  probable tRNA methyltransferase 9B isoform X3

    See identical proteins and their annotated locations for XP_011542903.1

    Conserved Domains (1) summary
    pfam13649
    Location:68155
    Methyltransf_25; Methyltransferase domain
  2. XM_011544596.3XP_011542898.1  probable tRNA methyltransferase 9B isoform X1

    See identical proteins and their annotated locations for XP_011542898.1

    Conserved Domains (1) summary
    cl17173
    Location:86224
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. XM_024447216.1XP_024302984.1  probable tRNA methyltransferase 9B isoform X5

    Conserved Domains (1) summary
    pfam13649
    Location:22104
    Methyltransf_25; Methyltransferase domain
  4. XM_005273586.4XP_005273643.1  probable tRNA methyltransferase 9B isoform X4

    See identical proteins and their annotated locations for XP_005273643.1

    UniProtKB/Swiss-Prot
    Q9P272
    Conserved Domains (1) summary
    pfam13649
    Location:48135
    Methyltransf_25; Methyltransferase domain
  5. XM_005273585.4XP_005273642.1  probable tRNA methyltransferase 9B isoform X3

    See identical proteins and their annotated locations for XP_005273642.1

    Conserved Domains (1) summary
    pfam13649
    Location:68155
    Methyltransf_25; Methyltransferase domain
  6. XM_017013710.1XP_016869199.1  probable tRNA methyltransferase 9B isoform X5

    Conserved Domains (1) summary
    pfam13649
    Location:22104
    Methyltransf_25; Methyltransferase domain
  7. XM_011544597.3XP_011542899.1  probable tRNA methyltransferase 9B isoform X1

    See identical proteins and their annotated locations for XP_011542899.1

    Conserved Domains (1) summary
    cl17173
    Location:86224
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  8. XM_005273588.5XP_005273645.1  probable tRNA methyltransferase 9B isoform X5

    See identical proteins and their annotated locations for XP_005273645.1

    Conserved Domains (1) summary
    pfam13649
    Location:22104
    Methyltransf_25; Methyltransferase domain
  9. XM_024447219.1XP_024302987.1  probable tRNA methyltransferase 9B isoform X8

  10. XM_005273591.5XP_005273648.1  probable tRNA methyltransferase 9B isoform X6

    See identical proteins and their annotated locations for XP_005273648.1

    Conserved Domains (1) summary
    pfam13649
    Location:1599
    Methyltransf_25; Methyltransferase domain
  11. XM_017013714.2XP_016869203.1  probable tRNA methyltransferase 9B isoform X7

    Conserved Domains (2) summary
    PRK08317
    Location:495
    PRK08317; hypothetical protein; Provisional
    pfam13649
    Location:248
    Methyltransf_25; Methyltransferase domain
  12. XM_011544598.2XP_011542900.1  probable tRNA methyltransferase 9B isoform X3

    See identical proteins and their annotated locations for XP_011542900.1

    Conserved Domains (1) summary
    pfam13649
    Location:68155
    Methyltransf_25; Methyltransferase domain
  13. XM_024447215.1XP_024302983.1  probable tRNA methyltransferase 9B isoform X4

    Conserved Domains (1) summary
    pfam13649
    Location:48135
    Methyltransf_25; Methyltransferase domain
  14. XM_024447214.1XP_024302982.1  probable tRNA methyltransferase 9B isoform X3

    Conserved Domains (1) summary
    pfam13649
    Location:68155
    Methyltransf_25; Methyltransferase domain
  15. XM_017013706.2XP_016869195.1  probable tRNA methyltransferase 9B isoform X4

    UniProtKB/Swiss-Prot
    Q9P272
    Conserved Domains (1) summary
    pfam13649
    Location:48135
    Methyltransf_25; Methyltransferase domain
  16. XM_005273584.5XP_005273641.1  probable tRNA methyltransferase 9B isoform X2

    Conserved Domains (1) summary
    cl17173
    Location:70208
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  17. XM_017013705.2XP_016869194.1  probable tRNA methyltransferase 9B isoform X4

    UniProtKB/Swiss-Prot
    Q9P272
    Conserved Domains (1) summary
    pfam13649
    Location:48135
    Methyltransf_25; Methyltransferase domain
  18. XM_011544600.3XP_011542902.1  probable tRNA methyltransferase 9B isoform X3

    See identical proteins and their annotated locations for XP_011542902.1

    Conserved Domains (1) summary
    pfam13649
    Location:68155
    Methyltransf_25; Methyltransferase domain
  19. XM_024447217.1XP_024302985.1  probable tRNA methyltransferase 9B isoform X6

    Conserved Domains (1) summary
    pfam13649
    Location:1599
    Methyltransf_25; Methyltransferase domain
  20. XM_024447218.1XP_024302986.1  probable tRNA methyltransferase 9B isoform X7

    Conserved Domains (2) summary
    PRK08317
    Location:495
    PRK08317; hypothetical protein; Provisional
    pfam13649
    Location:248
    Methyltransf_25; Methyltransferase domain
  21. XM_005273590.4XP_005273647.1  probable tRNA methyltransferase 9B isoform X6

    See identical proteins and their annotated locations for XP_005273647.1

    Conserved Domains (1) summary
    pfam13649
    Location:1599
    Methyltransf_25; Methyltransferase domain

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p13 PATCHES

    Range
    6141094..6225206
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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