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TRMT5 tRNA methyltransferase 5 [ Homo sapiens (human) ]

Gene ID: 57570, updated on 5-Mar-2024

Summary

Official Symbol
TRMT5provided by HGNC
Official Full Name
tRNA methyltransferase 5provided by HGNC
Primary source
HGNC:HGNC:23141
See related
Ensembl:ENSG00000126814 MIM:611023; AllianceGenome:HGNC:23141
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRM5; PNSED; COXPD26; KIAA1393
Summary
tRNAs contain as many as 13 or 14 nucleotides that are modified posttranscriptionally by enzymes that are highly specific for particular nucleotides in the tRNA structure. TRMT5 methylates the N1 position of guanosine-37 (G37) in selected tRNAs using S-adenosyl methionine (Brule et al., 2004 [PubMed 15248782]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in testis (RPKM 5.1), ovary (RPKM 4.1) and 25 other tissues See more
Orthologs
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Genomic context

See TRMT5 in Genome Data Viewer
Location:
14q23.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (60971441..60981690, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (55177981..55188230, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (61438159..61448408, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:61246210-61246710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:61246711-61247211 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:61256800-61257329 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:61260034-61260243 Neighboring gene MNAT1 component of CDK activating kinase Neighboring gene mitotic arrest deficient 2 like 1 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 12651 Neighboring gene Sharpr-MPRA regulatory region 14697 Neighboring gene Sharpr-MPRA regulatory region 5996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8484 Neighboring gene SRM pseudogene 2 Neighboring gene RNA, U6 small nuclear 398, pseudogene Neighboring gene uncharacterized LOC101927756 Neighboring gene solute carrier family 38 member 6 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:61555743-61556244 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8485 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:61567888-61568804 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:61570068-61571267 Neighboring gene Sharpr-MPRA regulatory region 14232 Neighboring gene NANOG hESC enhancer GRCh37_chr14:61641010-61641511 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:61644371-61644872 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:61644987-61646186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8486 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:61721487-61722686 Neighboring gene protein kinase C eta Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:61736629-61737128 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:61746518-61747481 Neighboring gene transmembrane protein 30B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of TRM5 tRNA methyltransferase 5 homolog (TRMT5) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC111453

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables tRNA (guanine(37)-N1)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables tRNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in mitochondrial tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrial tRNA methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tRNA N1-guanine methylation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tRNA (guanine(37)-N1)-methyltransferase
Names
M1G-methyltransferase
TRM5 tRNA methyltransferase 5 homolog
tRNA (guanine-N(1)-)-methyltransferase
tRNA [GM37] methyltransferase
tRNA-N1G37 methyltransferase
NP_001337182.1
NP_001337183.1
NP_065861.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053119.1 RefSeqGene

    Range
    5612..15250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001350253.1NP_001337182.1  tRNA (guanine(37)-N1)-methyltransferase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL160236, KF455905
    Conserved Domains (1) summary
    cl27846
    Location:125497
    Met_10; Met-10+ like-protein
  2. NM_001350254.1NP_001337183.1  tRNA (guanine(37)-N1)-methyltransferase isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' terminal exon, resulting in a different 5' UTR and the use of an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus, and is shorter, compared to isoform 1.
    Source sequence(s)
    AL160236, KF455905
    Conserved Domains (1) summary
    cl27846
    Location:124496
    Met_10; Met-10+ like-protein
  3. NM_020810.3NP_065861.3  tRNA (guanine(37)-N1)-methyltransferase isoform 3

    See identical proteins and their annotated locations for NP_065861.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' terminal exon, resulting in a different 5' UTR and the use of an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus, and is shorter, compared to isoform 1.
    Source sequence(s)
    AK293158, AL160236, DC370229
    Consensus CDS
    CCDS32092.1
    UniProtKB/Swiss-Prot
    B2RN19, Q32P41, Q9P2F4
    Related
    ENSP00000261249.6, ENST00000261249.7
    Conserved Domains (1) summary
    cl27846
    Location:97469
    Met_10; Met-10+ like-protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    60971441..60981690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    55177981..55188230 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)