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Trmt5 TRM5 tRNA methyltransferase 5 [ Mus musculus (house mouse) ]

Gene ID: 76357, updated on 2-Nov-2024

Summary

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Official Symbol
Trmt5provided by MGI
Official Full Name
TRM5 tRNA methyltransferase 5provided by MGI
Primary source
MGI:MGI:1923607
See related
Ensembl:ENSMUSG00000034442 AllianceGenome:MGI:1923607
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1393; 2610027O18Rik
Summary
Predicted to enable tRNA methyltransferase activity. Predicted to be involved in mitochondrial tRNA methylation and tRNA N1-guanine methylation. Predicted to be located in nucleus. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 26. Orthologous to human TRMT5 (tRNA methyltransferase 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in heart adult (RPKM 3.4), CNS E11.5 (RPKM 3.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Trmt5 in Genome Data Viewer
Location:
12 C3; 12 30.42 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (73315289..73333754, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (73268515..73286975, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene menage a trois 1 Neighboring gene STARR-positive B cell enhancer ABC_E7146 Neighboring gene nuclear transport factor 2 pseudogene Neighboring gene cytochrome c oxidase subunit 7A2, mitochondrial pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9148 Neighboring gene STARR-seq mESC enhancer starr_32467 Neighboring gene solute carrier family 38, member 6 Neighboring gene STARR-seq mESC enhancer starr_32469 Neighboring gene RIKEN cDNA D830013O20 gene Neighboring gene predicted gene, 40442 Neighboring gene predicted gene, 33929

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides. Perniss A, et al. Immunity, 2020 Apr 14. PMID 32294408
  2. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides.
    Title: Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1393

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables tRNA (guanine(37)-N1)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitochondrial tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial tRNA methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial tRNA methylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tRNA N1-guanine methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tRNA (guanine(37)-N1)-methyltransferase
Names
M1G-methyltransferase
TRM5 tRNA methyltransferase 5 homolog
tRNA (guanine-N(1)-)-methyltransferase
tRNA [GM37] methyltransferase
tRNA methyltransferase 5 homolog
NP_001405058.1
NP_001405059.1
NP_001405060.1
NP_001405061.1
NP_083856.1
XP_006516420.1
XP_006516421.1
XP_017170731.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418129.1 → NP_001405058.1  tRNA (guanine(37)-N1)-methyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122025, AC159813

  2. NM_001418130.1 → NP_001405059.1  tRNA (guanine(37)-N1)-methyltransferase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122025, AC159813

  3. NM_001418131.1 → NP_001405060.1  tRNA (guanine(37)-N1)-methyltransferase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC122025, AC159813

  4. NM_001418132.1 → NP_001405061.1  tRNA (guanine(37)-N1)-methyltransferase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC122025, AC159813

  5. NM_029580.4 → NP_083856.1  tRNA (guanine(37)-N1)-methyltransferase isoform 1

    See identical proteins and their annotated locations for NP_083856.1

    Status: VALIDATED

    Source sequence(s)
    AC122025, AC159813
    Consensus CDS
    CCDS36474.1
    UniProtKB/Swiss-Prot
    Q5DTY1, Q9D0C4
    Related
    ENSMUSP00000112121.3, ENSMUST00000116420.4
    Conserved Domains (2) summary
    COG2520
    Location:90 → 462
    Trm5; tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]
    pfam12847
    Location:291 → 352
    Methyltransf_18; Methyltransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    73315289..73333754 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516358.4 → XP_006516421.1  tRNA (guanine(37)-N1)-methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006516421.1

    Conserved Domains (1) summary
    COG2520
    Location:38 → 410
    Trm5; tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]

  2. XM_006516357.3 → XP_006516420.1  tRNA (guanine(37)-N1)-methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006516420.1

    Conserved Domains (1) summary
    COG2520
    Location:38 → 410
    Trm5; tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]

  3. XM_017315242.3 → XP_017170731.1  tRNA (guanine(37)-N1)-methyltransferase isoform X1

    Conserved Domains (1) summary
    COG2520
    Location:38 → 410
    Trm5; tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]

RNA

  1. XR_872724.4 RNA Sequence

  2. XR_872723.4 RNA Sequence

  3. XR_004937554.1 RNA Sequence

  4. XR_004937555.1 RNA Sequence

  5. XR_872722.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D0C4.1 GenPept UniProtKB/Swiss-Prot:Q9D0C4

Gene LinkOut

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