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PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 [ Homo sapiens (human) ]

Gene ID: 57546, updated on 5-Apr-2020

Summary

Official Symbol
PDP2provided by HGNC
Official Full Name
pyruvate dehyrogenase phosphatase catalytic subunit 2provided by HGNC
Primary source
HGNC:HGNC:30263
See related
Ensembl:ENSG00000172840 MIM:615499
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPM2B; PDPC 2; PPM2C2
Summary
This gene is a mitochondrial protein that functions as a phosphatase and is involved in the enzymatic resetting of the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2016]
Expression
Ubiquitous expression in thyroid (RPKM 4.8), kidney (RPKM 4.0) and 25 other tissues See more
Orthologs

Genomic context

See PDP2 in Genome Data Viewer
Location:
16q22.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (66880515..66891101)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (66914360..66925004)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene NEDD8 activating enzyme E1 subunit 1 Neighboring gene carbonic anhydrase 7 Neighboring gene uncharacterized LOC107984821 Neighboring gene VISTA enhancer hs1760 Neighboring gene cadherin 16

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1348

Gene Ontology Provided by GOA

Function Evidence Code Pubs
[pyruvate dehydrogenase (lipoamide)] phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
magnesium-dependent protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
positive regulation of pyruvate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of acetyl-CoA biosynthetic process from pyruvate TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial
Names
protein phosphatase 2C, magnesium-dependent, catalytic subunit 2
protein phosphatase, Mg2+/Mn2+ dependent 2B
pyruvate dehydrogenase phosphatase isoenzyme 2
NP_001316857.1
NP_001316858.1
NP_001316859.1
NP_001316860.1
NP_001316861.1
NP_001316862.1
NP_001316863.1
NP_065837.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051332.2 RefSeqGene

    Range
    5155..15741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001329928.2NP_001316857.1  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor

    Status: REVIEWED

    Source sequence(s)
    AC044802
    Consensus CDS
    CCDS10822.1
    UniProtKB/Swiss-Prot
    Q9P2J9
    Conserved Domains (1) summary
    cd00143
    Location:109517
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
  2. NM_001329929.2NP_001316858.1  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor

    Status: REVIEWED

    Source sequence(s)
    AC044802
    Consensus CDS
    CCDS10822.1
    UniProtKB/Swiss-Prot
    Q9P2J9
    Conserved Domains (1) summary
    cd00143
    Location:109517
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
  3. NM_001329930.2NP_001316859.1  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor

    Status: REVIEWED

    Source sequence(s)
    AC044802
    Consensus CDS
    CCDS10822.1
    UniProtKB/Swiss-Prot
    Q9P2J9
    Conserved Domains (1) summary
    cd00143
    Location:109517
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
  4. NM_001329931.2NP_001316860.1  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor

    Status: REVIEWED

    Source sequence(s)
    AC044802
    Consensus CDS
    CCDS10822.1
    UniProtKB/Swiss-Prot
    Q9P2J9
    Conserved Domains (1) summary
    cd00143
    Location:109517
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
  5. NM_001329932.2NP_001316861.1  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor

    Status: REVIEWED

    Source sequence(s)
    AC044802, DA107466, HY057277
    Consensus CDS
    CCDS10822.1
    UniProtKB/Swiss-Prot
    Q9P2J9
    Conserved Domains (1) summary
    cd00143
    Location:109517
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
  6. NM_001329933.2NP_001316862.1  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor

    Status: REVIEWED

    Source sequence(s)
    AC044802
    Consensus CDS
    CCDS10822.1
    UniProtKB/Swiss-Prot
    Q9P2J9
    Conserved Domains (1) summary
    cd00143
    Location:109517
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
  7. NM_001329934.2NP_001316863.1  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor

    Status: REVIEWED

    Source sequence(s)
    AC044802
    Consensus CDS
    CCDS10822.1
    UniProtKB/Swiss-Prot
    Q9P2J9
    Conserved Domains (1) summary
    cd00143
    Location:109517
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
  8. NM_020786.4NP_065837.1  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_065837.1

    Status: REVIEWED

    Source sequence(s)
    AC044802, AK292539, BM668681
    Consensus CDS
    CCDS10822.1
    UniProtKB/Swiss-Prot
    Q9P2J9
    Related
    ENSP00000309548.2, ENST00000311765.4
    Conserved Domains (1) summary
    cd00143
    Location:109517
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    66880515..66891101
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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