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STARD9 StAR related lipid transfer domain containing 9 [ Homo sapiens (human) ]

Gene ID: 57519, updated on 3-Nov-2024

Summary

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Official Symbol
STARD9provided by HGNC
Official Full Name
StAR related lipid transfer domain containing 9provided by HGNC
Primary source
HGNC:HGNC:19162
See related
Ensembl:ENSG00000159433 MIM:614642; AllianceGenome:HGNC:19162
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIF16A
Summary
Enables microtubule binding activity and microtubule motor activity. Involved in spindle assembly. Located in centriole; cytoplasm; and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 7.1), ovary (RPKM 3.6) and 22 other tissues See more
Orthologs
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Genomic context

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See STARD9 in Genome Data Viewer
Location:
15q15.2
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (42575606..42720998)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (40382607..40528130)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (42867804..43013196)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9304 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6374 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6375 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9305 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9306 Neighboring gene HAUS augmin like complex subunit 2 Neighboring gene eukaryotic translation initiation factor 4E binding protein 2 pseudogene 2 Neighboring gene MYL12B pseudogene 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:42892996-42893612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9307 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:42911331-42912096 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:42912097-42912861 Neighboring gene NANOG hESC enhancer GRCh37_chr15:42957961-42958533 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:43022854-43023381 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6376 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6378 Neighboring gene TTBK2 antisense RNA 1 Neighboring gene codanin 1 Neighboring gene tau tubulin kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification and characterization of the human StARD9 gene in the LGMD2A-region on chromosome 15q15 by in silico methods. Halama N, et al. Int J Mol Med, 2006 Oct. PMID 16964419
  2. Next-generation DNA sequencing identifies novel gene variants and pathways involved in specific language impairment. Chen XS, et al. Sci Rep, 2017 Apr 25. PMID 28440294, Free PMC Article
  3. A novel genetic syndrome with STARD9 mutation and abnormal spindle morphology. Okamoto N, et al. Am J Med Genet A, 2017 Oct. PMID 28777490
  4. A centrosomal protein STARD9 promotes microtubule stability and regulates spindle microtubule dynamics. Srivastava S, et al. Cell Cycle, 2018. PMID 30160609, Free PMC Article
  5. The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly. Torres JZ, et al. Cell, 2011 Dec 9. PMID 22153075, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. STARD9 regulates the assembly and stability of both interphase and spindle microtubules.
    Title: A centrosomal protein STARD9 promotes microtubule stability and regulates spindle microtubule dynamics.
  2. STARD9 frame shift mutation is associated with abnormal spindle morphology in Intellectual disability.
    Title: A novel genetic syndrome with STARD9 mutation and abnormal spindle morphology.
  3. STARD9 could be regulated by Plk1 and SCFbeta-TrCP to promote proper mitotic spindle assembly.
    Title: A unique insertion in STARD9's motor domain regulates its stability.
  4. Analysis of 592 mitotic microtubule copurifying proteins by functional RNAi screens for mitotic arrest, checkpoint bypass, and induction of apoptosis resulted in identification of a kinesin, STARD9, with a critical role in cancer cell division.
    Title: The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly.
  5. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Triplosensitivity

Not yet evaluated (Last evaluated 2023-10-10)

ClinGen Genome Curation Page
Haploinsufficency

No evidence available (Last evaluated 2023-10-10)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide association study identifies protein quantitative trait loci (pQTLs).
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16106, FLJ21936, KIAA1300, DKFZp686O248, DKFZp781J069, DKFZp686P19131

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
stAR-related lipid transfer protein 9
Names
START domain-containing protein 9
StAR-related lipid transfer (START) domain containing 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020759.3 → NP_065810.2  stAR-related lipid transfer protein 9

    See identical proteins and their annotated locations for NP_065810.2

    Status: VALIDATED

    Source sequence(s)
    AC018362, AC090510
    Consensus CDS
    CCDS53935.1
    UniProtKB/Swiss-Prot
    Q68DG2, Q6AI01, Q6ZWK0, Q9P2P6, Q9UF70
    Related
    ENSP00000290607.7, ENST00000290607.12
    Conserved Domains (5) summary
    cd08874
    Location:4496 → 4700
    START_STARD9-like; C-terminal START domain of mammalian STARD9, and related domains; lipid binding
    smart00129
    Location:3 → 391
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:478 → 578
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:2 → 391
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam16183
    Location:390 → 501
    Kinesin_assoc; Kinesin-associated

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    42575606..42720998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521831.4 → XP_011520133.1  stAR-related lipid transfer protein 9 isoform X1

    Conserved Domains (4) summary
    TIGR01843
    Location:581 → 776
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family
    cd08874
    Location:4496 → 4705
    START_STARD9-like; C-terminal START domain of mammalian STARD9, and related domains; lipid binding
    cd00060
    Location:478 → 578
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:2 → 391
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

  2. XM_011521834.4 → XP_011520136.1  stAR-related lipid transfer protein 9 isoform X4

    Conserved Domains (5) summary
    cd08874
    Location:4475 → 4684
    START_STARD9-like; C-terminal START domain of mammalian STARD9, and related domains; lipid binding
    smart00129
    Location:3 → 391
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:457 → 557
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:2 → 391
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam16183
    Location:390 → 471
    Kinesin_assoc; Kinesin-associated

  3. XM_017022439.3 → XP_016877928.1  stAR-related lipid transfer protein 9 isoform X5

  4. XM_011521835.4 → XP_011520137.1  stAR-related lipid transfer protein 9 isoform X7

    Conserved Domains (4) summary
    cd08874
    Location:4449 → 4658
    START_STARD9-like; C-terminal START domain of mammalian STARD9, and related domains; lipid binding
    smart00129
    Location:3 → 391
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:431 → 531
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:2 → 391
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

  5. XM_011521833.3 → XP_011520135.1  stAR-related lipid transfer protein 9 isoform X3

    Conserved Domains (5) summary
    cd08874
    Location:4485 → 4694
    START_STARD9-like; C-terminal START domain of mammalian STARD9, and related domains; lipid binding
    smart00129
    Location:3 → 380
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:467 → 567
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl22853
    Location:2 → 380
    Motor_domain; Myosin and Kinesin motor domain
    pfam16183
    Location:379 → 490
    Kinesin_assoc; Kinesin-associated

  6. XM_047432901.1 → XP_047288857.1  stAR-related lipid transfer protein 9 isoform X6

  7. XM_047432902.1 → XP_047288858.1  stAR-related lipid transfer protein 9 isoform X9

  8. XM_011521832.3 → XP_011520134.1  stAR-related lipid transfer protein 9 isoform X2

    Conserved Domains (5) summary
    cd08874
    Location:4495 → 4704
    START_STARD9-like; C-terminal START domain of mammalian STARD9, and related domains; lipid binding
    smart00129
    Location:3 → 390
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:477 → 577
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:2 → 390
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam16183
    Location:389 → 500
    Kinesin_assoc; Kinesin-associated

  9. XM_017022440.2 → XP_016877929.1  stAR-related lipid transfer protein 9 isoform X8

    Conserved Domains (5) summary
    cd08874
    Location:4442 → 4651
    START_STARD9-like; C-terminal START domain of mammalian STARD9, and related domains; lipid binding
    smart00129
    Location:3 → 337
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:424 → 524
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl22853
    Location:1 → 337
    Motor_domain; Myosin and Kinesin motor domain
    pfam16183
    Location:336 → 447
    Kinesin_assoc; Kinesin-associated

  10. XM_011521837.4 → XP_011520139.1  stAR-related lipid transfer protein 9 isoform X11

    Conserved Domains (5) summary
    cd08874
    Location:4412 → 4621
    START_STARD9-like; C-terminal START domain of mammalian STARD9, and related domains; lipid binding
    smart00129
    Location:2 → 307
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:394 → 494
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl22853
    Location:2 → 307
    Motor_domain; Myosin and Kinesin motor domain
    pfam16183
    Location:306 → 417
    Kinesin_assoc; Kinesin-associated

  11. XM_047432903.1 → XP_047288859.1  stAR-related lipid transfer protein 9 isoform X13

  12. XM_024450002.2 → XP_024305770.1  stAR-related lipid transfer protein 9 isoform X14

    Conserved Domains (4) summary
    cd00060
    Location:478 → 578
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:2 → 391
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam16183
    Location:390 → 501
    Kinesin_assoc; Kinesin-associated
    cl25632
    Location:581 → 776
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family

  13. XM_011521836.3 → XP_011520138.1  stAR-related lipid transfer protein 9 isoform X8

    Conserved Domains (5) summary
    cd08874
    Location:4442 → 4651
    START_STARD9-like; C-terminal START domain of mammalian STARD9, and related domains; lipid binding
    smart00129
    Location:3 → 337
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:424 → 524
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl22853
    Location:1 → 337
    Motor_domain; Myosin and Kinesin motor domain
    pfam16183
    Location:336 → 447
    Kinesin_assoc; Kinesin-associated

  14. XM_017022441.3 → XP_016877930.1  stAR-related lipid transfer protein 9 isoform X10

  15. XM_017022442.1 → XP_016877931.1  stAR-related lipid transfer protein 9 isoform X12

    Conserved Domains (4) summary
    cd08874
    Location:4258 → 4467
    START_STARD9-like; C-terminal START domain of mammalian STARD9, and related domains; lipid binding
    cd00060
    Location:240 → 340
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl22853
    Location:19 → 153
    Motor_domain; Myosin and Kinesin motor domain
    pfam16183
    Location:152 → 263
    Kinesin_assoc; Kinesin-associated

  16. XM_017022443.1 → XP_016877932.1  stAR-related lipid transfer protein 9 isoform X12

    Conserved Domains (4) summary
    cd08874
    Location:4258 → 4467
    START_STARD9-like; C-terminal START domain of mammalian STARD9, and related domains; lipid binding
    cd00060
    Location:240 → 340
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cl22853
    Location:19 → 153
    Motor_domain; Myosin and Kinesin motor domain
    pfam16183
    Location:152 → 263
    Kinesin_assoc; Kinesin-associated

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    40382607..40528130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378515.1 → XP_054234490.1  stAR-related lipid transfer protein 9 isoform X1

  2. XM_054378518.1 → XP_054234493.1  stAR-related lipid transfer protein 9 isoform X4

  3. XM_054378519.1 → XP_054234494.1  stAR-related lipid transfer protein 9 isoform X5

  4. XM_054378521.1 → XP_054234496.1  stAR-related lipid transfer protein 9 isoform X7

  5. XM_054378517.1 → XP_054234492.1  stAR-related lipid transfer protein 9 isoform X3

  6. XM_054378520.1 → XP_054234495.1  stAR-related lipid transfer protein 9 isoform X6

  7. XM_054378524.1 → XP_054234499.1  stAR-related lipid transfer protein 9 isoform X9

  8. XM_054378516.1 → XP_054234491.1  stAR-related lipid transfer protein 9 isoform X2

  9. XM_054378523.1 → XP_054234498.1  stAR-related lipid transfer protein 9 isoform X8

  10. XM_054378526.1 → XP_054234501.1  stAR-related lipid transfer protein 9 isoform X11

  11. XM_054378529.1 → XP_054234504.1  stAR-related lipid transfer protein 9 isoform X13

  12. XM_054378530.1 → XP_054234505.1  stAR-related lipid transfer protein 9 isoform X14

  13. XM_054378522.1 → XP_054234497.1  stAR-related lipid transfer protein 9 isoform X8

  14. XM_054378525.1 → XP_054234500.1  stAR-related lipid transfer protein 9 isoform X10

  15. XM_054378527.1 → XP_054234502.1  stAR-related lipid transfer protein 9 isoform X12

  16. XM_054378528.1 → XP_054234503.1  stAR-related lipid transfer protein 9 isoform X12

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_032381.1: Suppressed sequence

    Description
    NM_032381.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P2P6.3 GenPept UniProtKB/Swiss-Prot:Q9P2P6

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