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INTS2 integrator complex subunit 2 [ Homo sapiens (human) ]

Gene ID: 57508, updated on 5-Apr-2020

Summary

Official Symbol
INTS2provided by HGNC
Official Full Name
integrator complex subunit 2provided by HGNC
Primary source
HGNC:HGNC:29241
See related
Ensembl:ENSG00000108506 MIM:611346
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INT2; KIAA1287
Summary
INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in testis (RPKM 3.6), lymph node (RPKM 3.3) and 25 other tissues See more
Orthologs

Genomic context

See INTS2 in Genome Data Viewer
Location:
17q23.2
Exon count:
27
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (61865367..61927982, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (59942728..60005377, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene nascent polypeptide associated complex subunit alpha 2 Neighboring gene BRCA1 interacting protein C-terminal helicase 1 Neighboring gene VISTA enhancer hs778 Neighboring gene mediator complex subunit 13 Neighboring gene RNA, 7SL, cytoplasmic 800, pseudogene Neighboring gene RNA polymerase mitochondrial pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with INTS2 as demonstrated by proximity dependent biotinylation proteomics PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
snRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
snRNA transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrator complex IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
integrator complex subunit 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330417.2NP_001317346.2  integrator complex subunit 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC060798
    Consensus CDS
    CCDS82181.1
    Related
    ENSP00000496407.1, ENST00000647009.1
  2. NM_001351695.2NP_001338624.2  integrator complex subunit 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC060798
    Consensus CDS
    CCDS82181.1
    Related
    ENSP00000251334.6, ENST00000251334.6
  3. NM_020748.4NP_065799.2  integrator complex subunit 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC060798
    Consensus CDS
    CCDS45750.1
    Related
    ENSP00000414237.3, ENST00000444766.7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    61865367..61927982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525058.2XP_011523360.1  integrator complex subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_011523360.1

    UniProtKB/TrEMBL
    J3KMZ7
    Conserved Domains (1) summary
    pfam14750
    Location:231125
    INTS2; Integrator complex subunit 2

RNA

  1. XR_934509.3 RNA Sequence

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