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Ints2 integrator complex subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 70422, updated on 4-Dec-2022

Summary

Official Symbol
Ints2provided by MGI
Official Full Name
integrator complex subunit 2provided by MGI
Primary source
MGI:MGI:1917672
See related
Ensembl:ENSMUSG00000018068 AllianceGenome:MGI:1917672
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1287; 2810417D08Rik
Summary
Predicted to be involved in snRNA 3'-end processing. Predicted to be located in cytoplasm and nucleus. Predicted to be part of integrator complex. Orthologous to human INTS2 (integrator complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 9.9), CNS E14 (RPKM 7.3) and 24 other tissues See more
Orthologs
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Genomic context

See Ints2 in Genome Data Viewer
Location:
11; 11 C
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (86101507..86148912, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (86210681..86257609, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 20759 Neighboring gene BRCA1 interacting protein C-terminal helicase 1 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G, pseudogene 2 Neighboring gene BRCA1 interacting protein C-terminal helicase 1, opposite strand Neighboring gene mediator complex subunit 13 Neighboring gene small nucleolar RNA U3 Neighboring gene predicted gene, 38937

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC141509

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in snRNA processing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of integrator complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
integrator complex subunit 2
Names
int2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363129.1NP_001350058.1  integrator complex subunit 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL592065
    Consensus CDS
    CCDS25198.1
    UniProtKB/Swiss-Prot
    Q9CSE0
    Conserved Domains (1) summary
    pfam14750
    Location:241131
    INTS2; Integrator complex subunit 2
  2. NM_001363130.1NP_001350059.1  integrator complex subunit 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL592065, KY499705
    UniProtKB/TrEMBL
    A0A1S6GWJ5
    Related
    ENSMUSP00000103674.2, ENSMUST00000108039.8
    Conserved Domains (1) summary
    pfam14750
    Location:441151
    INTS2; Integrator complex subunit 2
  3. NM_027421.3NP_081697.2  integrator complex subunit 2 isoform 2

    See identical proteins and their annotated locations for NP_081697.2

    Status: VALIDATED

    Source sequence(s)
    AK129323, AK164097, AL592065, BC059056, CF166557
    Consensus CDS
    CCDS25198.1
    UniProtKB/Swiss-Prot
    Q80UK8, Q9CSE0
    UniProtKB/TrEMBL
    Q3TPV8
    Related
    ENSMUSP00000018212.7, ENSMUST00000018212.13
    Conserved Domains (1) summary
    pfam14750
    Location:241131
    INTS2; Integrator complex subunit 2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    86101507..86148912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534179.5XP_006534242.1  integrator complex subunit 2 isoform X3

    See identical proteins and their annotated locations for XP_006534242.1

    UniProtKB/Swiss-Prot
    Q80UK8, Q9CSE0
    Conserved Domains (1) summary
    pfam14750
    Location:241131
    INTS2; Integrator complex subunit 2
  2. XM_006534180.4XP_006534243.1  integrator complex subunit 2 isoform X3

    See identical proteins and their annotated locations for XP_006534243.1

    UniProtKB/Swiss-Prot
    Q80UK8, Q9CSE0
    Conserved Domains (1) summary
    pfam14750
    Location:241131
    INTS2; Integrator complex subunit 2
  3. XM_030246300.2XP_030102160.1  integrator complex subunit 2 isoform X3

    UniProtKB/Swiss-Prot
    Q9CSE0
    Conserved Domains (1) summary
    pfam14750
    Location:241131
    INTS2; Integrator complex subunit 2
  4. XM_006534176.4XP_006534239.1  integrator complex subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_006534239.1

    UniProtKB/TrEMBL
    A0A1S6GWJ5
    Conserved Domains (1) summary
    pfam14750
    Location:441151
    INTS2; Integrator complex subunit 2
  5. XM_006534178.5XP_006534241.1  integrator complex subunit 2 isoform X2

    Conserved Domains (1) summary
    pfam14750
    Location:341141
    INTS2; Integrator complex subunit 2
  6. XM_006534181.5XP_006534244.1  integrator complex subunit 2 isoform X3

    See identical proteins and their annotated locations for XP_006534244.1

    UniProtKB/Swiss-Prot
    Q80UK8, Q9CSE0
    Conserved Domains (1) summary
    pfam14750
    Location:241131
    INTS2; Integrator complex subunit 2
  7. XM_006534177.5XP_006534240.1  integrator complex subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_006534240.1

    UniProtKB/TrEMBL
    A0A1S6GWJ5
    Conserved Domains (1) summary
    pfam14750
    Location:441151
    INTS2; Integrator complex subunit 2

RNA

  1. XR_879737.4 RNA Sequence