RAB22A RAB22A, member RAS oncogene family [Homo sapiens (human)] - Gene

Summary

Official Symbol: RAB22Aprovided by HGNC
Official Full Name: RAB22A, member RAS oncogene familyprovided by HGNC
Primary source: HGNC:HGNC:9764
See related: Ensembl:ENSG00000124209 MIM:612966
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in brain (RPKM 7.8), adrenal (RPKM 6.5) and 25 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 20q13.32

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
109.20190607	current	GRCh38.p13 (GCF_000001405.39)	20	NC_000020.11 (58309715..58367507)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (56884771..56942563)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Study shows that the upregulation of RAB22A is associated with breast cancer progression and lymph node metastasis. Findings demonstrate that oncogenic RAB22A, regulated by miR-193b, affects the exosome-mediated growth, invasion, and metastasis of the recipient breast cancer cells.
Title: Regulation of RAB22A by mir-193b inhibits breast cancer growth and metastasis mediated by exosomes.
RAB22A is significantly upregulated in melanoma, plays an oncogenic role in the malignant phenotypes of melanoma cells, and its expression in melanoma is regulated by epigenetical mechanism.
Title: RAB22A overexpression promotes the tumor growth of melanoma.
that Rab22a enhances recycling of CD147, which is required for lung cancer cell migration and invasion
Title: Rab22a enhances CD147 recycling and is required for lung cancer cell migration and invasion.
Rab3A-22A blocks exocytosis at a stage downstream intra-acrosomal calcium release.
Title: The Rab3A-22A Chimera Prevents Sperm Exocytosis by Stabilizing Open Fusion Pores.
RAB22A role in epithelial-mesenchymal transition of melanoma cells
Title: MiR-211 is epigenetically regulated by DNMT1 mediated methylation and inhibits EMT of melanoma cells by targeting RAB22A.
the HOTAIR lncRNA positively regulated the protein expression of Rab22a through competition for miR-373 binding. the positive regulation between HOTAIR and Rab22a may be partially attributed to the ceRNA regulatory network via miR-373, indicating a potential therapeutic target for ovarian cancer.
Title: LncRNA HOTAIR controls the expression of Rab22a by sponging miR-373 in ovarian cancer.
miR-204 suppressed renal cell carcinoma proliferation and invasion by directly targeting the RAB22A gene.
Title: MiR-204 inhibits the proliferation and invasion of renal cell carcinoma by inhibiting RAB22A expression.
Data show that Rab22a- and Rab5a-driven phagosomal uptake is a crucial step in the vesicular cascade that leads to elimination of spirochetes by macrophages.
Title: ER-Coordinated Activities of Rab22a and Rab5a Drive Phagosomal Compaction and Intracellular Processing of Borrelia burgdorferi by Macrophages.
our results demonstrated that miR-203 act as a tumor suppressor miRNA through regulating RAB22A expression and suggested its involvement in osteosarcoma progression and carcinogenesis.
Title: miR-203 Acts as a Tumor Suppressor Gene in Osteosarcoma by Regulating RAB22A.
miR-204-5p acts as a tumor suppressor in gastric cancer through inhibiting USP47 and RAB22A.
Title: MicroRNA-204-5p inhibits gastric cancer cell proliferation by downregulating USP47 and RAB22A.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from BioSystems

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Endocytosis, organism-specific biosystem (from KEGG)
Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Endocytosis, conserved biosystem (from KEGG)
Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
Post-translational protein modification, organism-specific biosystem (from REACTOME)
Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
RAB geranylgeranylation, organism-specific biosystem (from REACTOME)
RAB geranylgeranylation, organism-specific biosystemHuman cells have more than 60 RAB proteins that are involved in trafficking of proteins in the endolysosomal system. These small GTPases contribute to trafficking specificity by localizing to the mem...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

WI-20991 (e-PCR)
- UniSTS:24628

RH11002 (e-PCR)
- UniSTS:60500

D10S16 (e-PCR)
- UniSTS:155756

D1S1425 (e-PCR)
- UniSTS:149621

RAB22A_1154 (e-PCR)
- UniSTS:277636

A006N26 (e-PCR)
- UniSTS:68754

RH15965 (e-PCR)
- UniSTS:40633

HSCZWA052 (e-PCR)
- UniSTS:40634

L17971 (e-PCR)
- UniSTS:43966

A002U04 (e-PCR)
- UniSTS:27614

Homology

Homologs of the RAB22A gene: The RAB22A gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
Orthologs from Annotation Pipeline: 265 organisms have orthologs with human gene RAB22A
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
GDP binding	IDA Inferred from Direct Assay more info	PubMed
GTP binding	IMP Inferred from Mutant Phenotype more info	PubMed
GTPase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
GTPase activity	TAS Traceable Author Statement more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
Rab protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info	PubMed
endocytosis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
endocytosis	IDA Inferred from Direct Assay more info	PubMed
endosome organization	IEP Inferred from Expression Pattern more info	PubMed
intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
regulation of vesicle size	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
actin cytoskeleton	IEA Inferred from Electronic Annotation more info
early endosome	IBA Inferred from Biological aspect of Ancestor more info	PubMed
early endosome	IDA Inferred from Direct Assay more info	PubMed
endosome membrane	IEA Inferred from Electronic Annotation more info
extracellular exosome	HDA more info	PubMed
late endosome	IEA Inferred from Electronic Annotation more info
phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
ruffle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ras-related protein Rab-22A

Names: GTP-binding protein RAB22A; rab-22

NP_065724.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020673.3 → NP_065724.1 ras-related protein Rab-22A

See identical proteins and their annotated locations for NP_065724.1

Status: REVIEWED

Source sequence(s)

AL035455, BC015710, BC042545, DB452461

Consensus CDS

CCDS33497.1

UniProtKB/Swiss-Prot

Q9UL26

Related

ENSP00000244040.3, ENST00000244040.4

Conserved Domains (2) summary

cd01860
Location:5 → 167

Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

pfam00071
Location:7 → 167

Ras; Ras family