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RAB22A RAB22A, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 57403, updated on 24-Jul-2021

Summary

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Official Symbol
RAB22Aprovided by HGNC
Official Full Name
RAB22A, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:9764
See related
Ensembl:ENSG00000124209 MIM:612966
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 7.8), adrenal (RPKM 6.5) and 25 other tissues See more
Orthologs
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Genomic context

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See RAB22A in Genome Data Viewer
Location:
20q13.32
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (58309715..58367507)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (56884771..56942563)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 60 Neighboring gene protein phosphatase 4 regulatory subunit 1 like (pseudogene) Neighboring gene VAMP associated protein B and C Neighboring gene APC down-regulated 1 like Neighboring gene APCDD1L divergent transcript

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Acetylation dependent functions of Rab22a-NeoF1 Fusion Protein in Osteosarcoma. Liang X, et al. Theranostics, 2020. PMID 32685017, Free PMC Article
  2. Chromosomal translocation-derived aberrant Rab22a drives metastasis of osteosarcoma. Liao D, et al. Nat Cell Biol, 2020 Jul. PMID 32483387
  3. Rab22a is a novel prognostic marker for cell progression in breast cancer. He M, et al. Int J Mol Med, 2020 Apr. PMID 32124943, Free PMC Article
  4. Differential requirement of Rab22a for the recruitment of ER-derived proteins to phagosomes and endosomes in dendritic cells. Croce C, et al. Small GTPases, 2020 May. PMID 28960134, Free PMC Article
  5. RAB22A overexpression promotes the tumor growth of melanoma. Su F, et al. Oncotarget, 2016 Nov 1. PMID 27690221, Free PMC Article

See all (56) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Differential requirement of Rab22a for the recruitment of ER-derived proteins to phagosomes and endosomes in dendritic cells.
    Title: Differential requirement of Rab22a for the recruitment of ER-derived proteins to phagosomes and endosomes in dendritic cells.
  2. Acetylation dependent functions of Rab22a-NeoF1 Fusion Protein in Osteosarcoma.
    Title: Acetylation dependent functions of Rab22a-NeoF1 Fusion Protein in Osteosarcoma.
  3. Long non-coding RNA PSMA3-AS1 enhances cell proliferation, migration and invasion by regulating miR-302a-3p/RAB22A in glioma.
    Title: Long non-coding RNA PSMA3-AS1 enhances cell proliferation, migration and invasion by regulating miR-302a-3p/RAB22A in glioma.
  4. Rab22a is a novel prognostic marker for cell progression in breast cancer.
    Title: Rab22a is a novel prognostic marker for cell progression in breast cancer.
  5. Chromosomal translocation-derived aberrant Rab22a drives metastasis of osteosarcoma.
    Title: Chromosomal translocation-derived aberrant Rab22a drives metastasis of osteosarcoma.
  6. LncRNA DLEU1/microRNA-300/RAB22A axis regulates migration and invasion of breast cancer cells.
    Title: LncRNA DLEU1/microRNA-300/RAB22A axis regulates migration and invasion of breast cancer cells.
  7. Overexpressing miR373 mimics in liver cancer cell lines decreased cell proliferation and invasion, suggesting that miR373 exerts antitumor effects in liver cancer. In addition, data from the present study demonstrated the direct effect of miR373 on inhibiting the expression and signaling of Rasrelated protein Rab22a, a wellknown oncoprotein.
    Title: MicroRNA‑373 exerts anti‑tumor functions in human liver cancer by targeting Rab22a.
  8. Rab22A promotes the assembly of a BLOC-1-BLOC-2-KIF13A complex on early/sorting endosomes.
    Title: Rab22A recruits BLOC-1 and BLOC-2 to promote the biogenesis of recycling endosomes.
  9. Study shows that the upregulation of RAB22A is associated with breast cancer progression and lymph node metastasis. Findings demonstrate that oncogenic RAB22A, regulated by miR-193b, affects the exosome-mediated growth, invasion, and metastasis of the recipient breast cancer cells.
    Title: Regulation of RAB22A by mir-193b inhibits breast cancer growth and metastasis mediated by exosomes.
  10. RAB22A is significantly upregulated in melanoma, plays an oncogenic role in the malignant phenotypes of melanoma cells, and its expression in melanoma is regulated by epigenetical mechanism.
    Title: RAB22A overexpression promotes the tumor growth of melanoma.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC16770

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GDP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables GTPase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables GTPase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in endosome organization IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of vesicle size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
located_in late endosome IEA
Inferred from Electronic Annotation
more info
  
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ruffle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras-related protein Rab-22A
Names
GTP-binding protein RAB22A
rab-22
NP_065724.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020673.3 → NP_065724.1  ras-related protein Rab-22A

    See identical proteins and their annotated locations for NP_065724.1

    Status: REVIEWED

    Source sequence(s)
    AL035455, BC015710, BC042545, DB452461
    Consensus CDS
    CCDS33497.1
    UniProtKB/Swiss-Prot
    Q9UL26
    Related
    ENSP00000244040.3, ENST00000244040.4
    Conserved Domains (2) summary
    cd01860
    Location:5 → 167
    Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
    pfam00071
    Location:7 → 167
    Ras; Ras family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    58309715..58367507
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UL26.2 GenPept UniProtKB/Swiss-Prot:Q9UL26

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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