Sign in to NCBI
Format

Send to:

Choose Destination

RAB22A RAB22A, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 57403, updated on 13-Mar-2020

Summary

Go to the top of the page Help
Official Symbol
RAB22Aprovided by HGNC
Official Full Name
RAB22A, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:9764
See related
Ensembl:ENSG00000124209 MIM:612966
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 7.8), adrenal (RPKM 6.5) and 25 other tissues See more
Orthologs
mouse all

Genomic context

Go to the top of the page Help
See RAB22A in Genome Data Viewer
Location:
20q13.32
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (58309715..58367507)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (56884771..56942563)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 60 Neighboring gene protein phosphatase 4 regulatory subunit 1 like (pseudogene) Neighboring gene VAMP associated protein B and C Neighboring gene APC down-regulated 1 like Neighboring gene APCDD1L divergent transcript

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. RAB22A overexpression promotes the tumor growth of melanoma. Su F, et al. Oncotarget, 2016 Nov 1. PMID 27690221, Free PMC Article
  2. Rab22a regulates the sorting of transferrin to recycling endosomes. Magadán JG, et al. Mol Cell Biol, 2006 Apr. PMID 16537905, Free PMC Article
  3. Overexpression of Rab22a hampers the transport between endosomes and the Golgi apparatus. Mesa R, et al. Exp Cell Res, 2005 Apr 1. PMID 15748882
  4. Rab22a regulates the recycling of membrane proteins internalized independently of clathrin. Weigert R, et al. Mol Biol Cell, 2004 Aug. PMID 15181155, Free PMC Article
  5. MicroRNA‑373 exerts anti‑tumor functions in human liver cancer by targeting Rab22a. Ye Y, et al. Mol Med Rep, 2019 Oct. PMID 31485646

See all (46) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpressing miR373 mimics in liver cancer cell lines decreased cell proliferation and invasion, suggesting that miR373 exerts antitumor effects in liver cancer. In addition, data from the present study demonstrated the direct effect of miR373 on inhibiting the expression and signaling of Rasrelated protein Rab22a, a wellknown oncoprotein.
    Title: MicroRNA‑373 exerts anti‑tumor functions in human liver cancer by targeting Rab22a.
  2. Rab22A promotes the assembly of a BLOC-1-BLOC-2-KIF13A complex on early/sorting endosomes.
    Title: Rab22A recruits BLOC-1 and BLOC-2 to promote the biogenesis of recycling endosomes.
  3. Study shows that the upregulation of RAB22A is associated with breast cancer progression and lymph node metastasis. Findings demonstrate that oncogenic RAB22A, regulated by miR-193b, affects the exosome-mediated growth, invasion, and metastasis of the recipient breast cancer cells.
    Title: Regulation of RAB22A by mir-193b inhibits breast cancer growth and metastasis mediated by exosomes.
  4. RAB22A is significantly upregulated in melanoma, plays an oncogenic role in the malignant phenotypes of melanoma cells, and its expression in melanoma is regulated by epigenetical mechanism.
    Title: RAB22A overexpression promotes the tumor growth of melanoma.
  5. that Rab22a enhances recycling of CD147, which is required for lung cancer cell migration and invasion
    Title: Rab22a enhances CD147 recycling and is required for lung cancer cell migration and invasion.
  6. Rab3A-22A blocks exocytosis at a stage downstream intra-acrosomal calcium release.
    Title: The Rab3A-22A Chimera Prevents Sperm Exocytosis by Stabilizing Open Fusion Pores.
  7. RAB22A role in epithelial-mesenchymal transition of melanoma cells
    Title: MiR-211 is epigenetically regulated by DNMT1 mediated methylation and inhibits EMT of melanoma cells by targeting RAB22A.
  8. the HOTAIR lncRNA positively regulated the protein expression of Rab22a through competition for miR-373 binding. the positive regulation between HOTAIR and Rab22a may be partially attributed to the ceRNA regulatory network via miR-373, indicating a potential therapeutic target for ovarian cancer.
    Title: LncRNA HOTAIR controls the expression of Rab22a by sponging miR-373 in ovarian cancer.
  9. miR-204 suppressed renal cell carcinoma proliferation and invasion by directly targeting the RAB22A gene.
    Title: MiR-204 inhibits the proliferation and invasion of renal cell carcinoma by inhibiting RAB22A expression.
  10. Data show that Rab22a- and Rab5a-driven phagosomal uptake is a crucial step in the vesicular cascade that leads to elimination of spirochetes by macrophages.
    Title: ER-Coordinated Activities of Rab22a and Rab5a Drive Phagosomal Compaction and Intracellular Processing of Borrelia burgdorferi by Macrophages.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC16770

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP binding IDA
Inferred from Direct Assay
more info
 PubMed 
GTP binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
GTPase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
GTPase activity TAS
Traceable Author Statement
more info
 PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
Rab protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
endosome organization IEP
Inferred from Expression Pattern
more info
 PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
regulation of vesicle size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
early endosome IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
endosome membrane IEA
Inferred from Electronic Annotation
more info
  
extracellular exosome HDA PubMed 
late endosome IEA
Inferred from Electronic Annotation
more info
  
phagocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
ruffle IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ras-related protein Rab-22A
Names
GTP-binding protein RAB22A
rab-22
NP_065724.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020673.3 → NP_065724.1  ras-related protein Rab-22A

    See identical proteins and their annotated locations for NP_065724.1

    Status: REVIEWED

    Source sequence(s)
    AL035455, BC015710, BC042545, DB452461
    Consensus CDS
    CCDS33497.1
    UniProtKB/Swiss-Prot
    Q9UL26
    Related
    ENSP00000244040.3, ENST00000244040.4
    Conserved Domains (2) summary
    cd01860
    Location:5 → 167
    Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
    pfam00071
    Location:7 → 167
    Ras; Ras family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    58309715..58367507
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UL26.2 GenPept UniProtKB/Swiss-Prot:Q9UL26

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous
You are here: NCBI > Genes & Expression > Gene
Support Center