Format

Send to:

Choose Destination

PTGFRN prostaglandin F2 receptor inhibitor [ Homo sapiens (human) ]

Gene ID: 5738, updated on 1-Jun-2020

Summary

Official Symbol
PTGFRNprovided by HGNC
Official Full Name
prostaglandin F2 receptor inhibitorprovided by HGNC
Primary source
HGNC:HGNC:9601
See related
Ensembl:ENSG00000134247 MIM:601204
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FPRP; CD315; EWI-F; CD9P-1; SMAP-6
Expression
Ubiquitous expression in heart (RPKM 21.3), endometrium (RPKM 18.0) and 24 other tissues See more
Orthologs

Genomic context

See PTGFRN in Genome Data Viewer
Location:
1p13.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (116909916..116990358)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (117452689..117532972)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ferritin heavy chain 1 pseudogene 22 Neighboring gene uncharacterized LOC105378927 Neighboring gene RNA, 5S ribosomal pseudogene 55 Neighboring gene Sharpr-MPRA regulatory region 2959 Neighboring gene CD101 molecule Neighboring gene uncharacterized LOC101929099 Neighboring gene transcription termination factor 2 Neighboring gene microRNA 942

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of prostaglandin F2 receptor inhibitor (PTGFRN) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11001, KIAA1436

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
lipid droplet organization IEA
Inferred from Electronic Annotation
more info
 
myoblast fusion involved in skeletal muscle regeneration ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cell surface HDA PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
prostaglandin F2 receptor negative regulator
Names
CD9 partner 1
glu-Trp-Ile EWI motif-containing protein F
prostaglandin F2-alpha receptor regulatory protein
prostaglandin F2-alpha receptor-associated protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020440.4NP_065173.2  prostaglandin F2 receptor negative regulator precursor

    See identical proteins and their annotated locations for NP_065173.2

    Status: VALIDATED

    Source sequence(s)
    AA045111, AB037857, AK074637, AL157904, DA572787
    Consensus CDS
    CCDS890.1
    UniProtKB/Swiss-Prot
    Q9P2B2
    Related
    ENSP00000376899.2, ENST00000393203.3
    Conserved Domains (3) summary
    smart00406
    Location:39121
    IGv; Immunoglobulin V-Type
    smart00410
    Location:30140
    IG_like; Immunoglobulin like
    cl11960
    Location:283376
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    116909916..116990358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001874.1XP_016857363.1  prostaglandin F2 receptor negative regulator isoform X1

Support Center