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ERGIC1 endoplasmic reticulum-golgi intermediate compartment 1 [ Homo sapiens (human) ]

Gene ID: 57222, updated on 11-Sep-2019

Summary

Official Symbol
ERGIC1provided by HGNC
Official Full Name
endoplasmic reticulum-golgi intermediate compartment 1provided by HGNC
Primary source
HGNC:HGNC:29205
See related
Ensembl:ENSG00000113719 MIM:617946
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AMCN; NET24; ERGIC32; ERGIC-32
Summary
This gene encodes a cycling membrane protein which is an endoplasmic reticulum-golgi intermediate compartment (ERGIC) protein which interacts with other members of this protein family to increase their turnover. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in prostate (RPKM 69.0), adrenal (RPKM 49.7) and 25 other tissues See more
Orthologs

Genomic context

See ERGIC1 in Genome Data Viewer
Location:
5q35.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (172834251..172952683)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (172261223..172379688)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs1828 Neighboring gene uncharacterized LOC105377730 Neighboring gene dual specificity phosphatase 1 Neighboring gene microRNA 10523 Neighboring gene uncharacterized LOC100268168 Neighboring gene ribosomal protein L26 like 1 Neighboring gene inorganic pyrophosphatase 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Arthrogryposis multiplex congenita neurogenic type
MedGen: C1859721 OMIM: 208100 GeneReviews: Spinal Muscular Atrophy
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
NHGRI GWA Catalog
Genome-wide association study of chronic periodontitis in a general German population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with ERGIC1; predicted interaction to be within the endoplasmic reticulum to Golgi transport PubMed
Nef nef HIV-1 Nef is identified to have a physical interaction with endoplasmic reticulum-golgi intermediate compartment 1 (ERGIC1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39864, KIAA1181, MGC14345

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ER to Golgi vesicle-mediated transport IDA
Inferred from Direct Assay
more info
PubMed 
retrograde vesicle-mediated transport, Golgi to ER IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
endoplasmic reticulum-Golgi intermediate compartment protein 1
Names
ER-Golgi intermediate compartment 32 kDa protein
endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1
endoplasmic reticulum-golgi intermediate compartment 32 kDa protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031711.3NP_001026881.1  endoplasmic reticulum-Golgi intermediate compartment protein 1

    See identical proteins and their annotated locations for NP_001026881.1

    Status: REVIEWED

    Source sequence(s)
    AB033007, BC014490, CD365875, DB443891
    Consensus CDS
    CCDS34292.1
    UniProtKB/Swiss-Prot
    Q969X5
    Related
    ENSP00000377374.3, ENST00000393784.8
    Conserved Domains (2) summary
    pfam07970
    Location:104271
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
    pfam13850
    Location:594
    ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    172834251..172952683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446135.1XP_024301903.1  endoplasmic reticulum-Golgi intermediate compartment protein 1 isoform X5

    Conserved Domains (1) summary
    pfam07970
    Location:12179
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
  2. XM_011534598.3XP_011532900.1  endoplasmic reticulum-Golgi intermediate compartment protein 1 isoform X3

    Conserved Domains (1) summary
    pfam13850
    Location:598
    ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)
  3. XM_017009654.1XP_016865143.1  endoplasmic reticulum-Golgi intermediate compartment protein 1 isoform X2

  4. XM_017009655.1XP_016865144.1  endoplasmic reticulum-Golgi intermediate compartment protein 1 isoform X4

  5. XM_011534597.1XP_011532899.1  endoplasmic reticulum-Golgi intermediate compartment protein 1 isoform X1

    Conserved Domains (2) summary
    pfam07970
    Location:128295
    COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
    pfam13850
    Location:31122
    ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

RNA

  1. XR_001742159.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_020462.1: Suppressed sequence

    Description
    NM_020462.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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