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THAP11 THAP domain containing 11 [ Homo sapiens (human) ]

Gene ID: 57215, updated on 4-Oct-2020

Summary

Official Symbol
THAP11provided by HGNC
Official Full Name
THAP domain containing 11provided by HGNC
Primary source
HGNC:HGNC:23194
See related
Ensembl:ENSG00000168286 MIM:609119
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RONIN; CTG-B43a; CTG-B45d; HRIHFB2206
Summary
The protein encoded by this gene contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See THAP11 in Genome Data Viewer
Location:
16q22.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (67842320..67844195)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67876213..67878098)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RAN binding protein 10 Neighboring gene translin associated factor X interacting protein 1 Neighboring gene centromere protein T Neighboring gene nuclear transport factor 2 Neighboring gene enhancer of mRNA decapping 4

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of THAP domain containing 11 (THAP11) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
intercellular bridge IDA
Inferred from Direct Assay
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
THAP domain-containing protein 11

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020457.3NP_065190.2  THAP domain-containing protein 11

    See identical proteins and their annotated locations for NP_065190.2

    Status: REVIEWED

    Source sequence(s)
    BC012182, BI261822, BQ898449
    Consensus CDS
    CCDS10847.1
    UniProtKB/Swiss-Prot
    Q96EK4
    Related
    ENSP00000304689.1, ENST00000303596.3
    Conserved Domains (1) summary
    pfam05485
    Location:581
    THAP; THAP domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    67842320..67844195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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