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PSME1 proteasome activator subunit 1 [ Homo sapiens (human) ]

Gene ID: 5720, updated on 1-Jun-2020

Summary

Official Symbol
PSME1provided by HGNC
Official Full Name
proteasome activator subunit 1provided by HGNC
Primary source
HGNC:HGNC:9568
See related
Ensembl:ENSG00000092010 MIM:600654
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PA28A; IFI5111; REGalpha; PA28alpha; HEL-S-129m
Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in lymph node (RPKM 102.3), spleen (RPKM 98.9) and 25 other tissues See more
Orthologs

Genomic context

See PSME1 in Genome Data Viewer
Location:
14q12
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (24136158..24138967)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24605295..24608176)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene neural retina leucine zipper Neighboring gene DDB1 and CUL4 associated factor 11 Neighboring gene fat storage inducing transmembrane protein 1 Neighboring gene ER membrane protein complex subunit 9 Neighboring gene microRNA 7703 Neighboring gene proteasome activator subunit 2 Neighboring gene ring finger protein 31 Neighboring gene RNA, 5S ribosomal pseudogene 383

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat slightly enhances the activity of the purified 26 S proteasome PubMed
tat Amino acids Lys51, Arg52, and Asp67 of HIV-1 Tat represent the proteasome binding site of Tat, and Tat amino acids 37-72 are necessary for proteasomal interaction and suppression of 11 S regulator-mediated antigen presentation PubMed
tat HIV-1 Tat inhibits the peptidase activity of the 20 S proteasome and interferes with the formation of the 20 S proteasome-11 S regulator complex PubMed
tat HIV-1 Tat binds to the alpha2, alpha4, alpha6, alpha7, beta1, beta2, beta3, beta5, beta6, beta7, LMP7/beta5i, and MECL1/beta2i subunits of the proteasome 20 S core structure and can inhibit cellular proteasome function PubMed
Vif vif HIV-1 Vif binds to the cellular cytidine deaminase APOBEC3G and targets it for degradation through an interaction with the proteasome, thereby inhibiting APOBEC3G mediated restriction of HIV-1 replication PubMed
capsid gag HIV-1 CA downregulates PA28beta and the beta2i subunit of the immunoproteasome complex in a dendritic cell line (JAWS II), whereas in primary dendritic cells, PA28alpha, beta2i, and beta5i are downregulated by CA PubMed
integrase gag-pol Proteasomal degradation of HIV-1 integrase in mammalian cells occurs by the N-end rule pathway PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8628, FLJ97098, FLJ98613

Gene Ontology Provided by GOA

Function Evidence Code Pubs
endopeptidase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
MAPK cascade TAS
Traceable Author Statement
more info
 
NIK/NF-kappaB signaling TAS
Traceable Author Statement
more info
 
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 
T cell receptor signaling pathway TAS
Traceable Author Statement
more info
 
Wnt signaling pathway, planar cell polarity pathway TAS
Traceable Author Statement
more info
 
anaphase-promoting complex-dependent catabolic process TAS
Traceable Author Statement
more info
 
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
Traceable Author Statement
more info
 
interleukin-1-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
negative regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cellular amino acid metabolic process TAS
Traceable Author Statement
more info
 
regulation of hematopoietic stem cell differentiation TAS
Traceable Author Statement
more info
 
regulation of mRNA stability TAS
Traceable Author Statement
more info
 
regulation of mitotic cell cycle phase transition TAS
Traceable Author Statement
more info
 
regulation of proteasomal protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
Traceable Author Statement
more info
 
stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
transmembrane transport TAS
Traceable Author Statement
more info
 
tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
proteasome activator complex IEA
Inferred from Electronic Annotation
more info
 
proteasome complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
proteasome activator complex subunit 1
Names
11S regulator complex subunit alpha
29-kD MCP activator subunit
IGUP I-5111
activator of multicatalytic protease subunit 1
epididymis secretory sperm binding protein Li 129m
interferon gamma up-regulated I-5111 protein
interferon-gamma IEF SSP 5111
interferon-gamma-inducible protein 5111
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281528.2NP_001268457.1  proteasome activator complex subunit 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 3, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BJ993879, BM981616, BU192084
    Consensus CDS
    CCDS61415.1
    UniProtKB/Swiss-Prot
    Q06323
    Related
    ENSP00000453976.1, ENST00000561435.5
    Conserved Domains (2) summary
    pfam02251
    Location:1067
    PA28_alpha; Proteasome activator pa28 alpha subunit
    pfam02252
    Location:103223
    PA28_beta; Proteasome activator pa28 beta subunit
  2. NM_001281529.2NP_001268458.1  proteasome activator complex subunit 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. It encodes isoform 4 which is shorter compared to isoform 1.
    Source sequence(s)
    AI445328, BJ993879, BM470561, BM981616
    Conserved Domains (2) summary
    pfam02251
    Location:1067
    PA28_alpha; Proteasome activator pa28 alpha subunit
    pfam02252
    Location:106234
    PA28_beta; Proteasome activator pa28 beta subunit
  3. NM_006263.4NP_006254.1  proteasome activator complex subunit 1 isoform 1

    See identical proteins and their annotated locations for NP_006254.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    BM981616, L07633
    Consensus CDS
    CCDS9612.1
    UniProtKB/Swiss-Prot
    Q06323
    UniProtKB/TrEMBL
    A0A0K0K1L8
    Related
    ENSP00000206451.6, ENST00000206451.11
    Conserved Domains (2) summary
    pfam02251
    Location:1067
    PA28_alpha; Proteasome activator pa28 alpha subunit
    pfam02252
    Location:103247
    PA28_beta; Proteasome activator pa28 beta subunit
  4. NM_176783.2NP_788955.1  proteasome activator complex subunit 1 isoform 2

    See identical proteins and their annotated locations for NP_788955.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' structure, and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct and longer C-terminus, compared to isoform 1.
    Source sequence(s)
    BJ993879, BM981616, BQ060125, BX248293
    Consensus CDS
    CCDS41930.1
    UniProtKB/TrEMBL
    Q86SZ9
    Related
    ENSP00000372155.3, ENST00000382708.7
    Conserved Domains (2) summary
    pfam02251
    Location:1067
    PA28_alpha; Proteasome activator pa28 alpha subunit
    pfam02252
    Location:106223
    PA28_beta; Proteasome activator pa28 beta subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    24136158..24138967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p13 PATCHES

    Range
    437136..439945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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