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Psme1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) [ Mus musculus (house mouse) ]

Gene ID: 19186, updated on 1-Mar-2024

Summary

Official Symbol
Psme1provided by MGI
Official Full Name
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)provided by MGI
Primary source
MGI:MGI:1096367
See related
Ensembl:ENSMUSG00000022216 AllianceGenome:MGI:1096367
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PA28a
Summary
Contributes to endopeptidase activator activity. Acts upstream of or within antigen processing and presentation of exogenous antigen. Predicted to be part of proteasome activator complex. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in several structures, including adipose tissue; alimentary system; eye; genitourinary system; and hemolymphoid system gland. Orthologous to human PSME1 (proteasome activator subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 93.4), liver E18 (RPKM 41.8) and 27 other tissues See more
Orthologs
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Genomic context

See Psme1 in Genome Data Viewer
Location:
14 C3; 14 28.19 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55815951..55818984)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55578494..55581527)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 11 Neighboring gene fat storage-inducing transmembrane protein 1 Neighboring gene ER membrane protein complex subunit 9 Neighboring gene STARR-positive B cell enhancer ABC_E5440 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:56210161-56210270 Neighboring gene proteasome (prosome, macropain) activator subunit 2 (PA28 beta) Neighboring gene ring finger protein 31

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC113815

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to endopeptidase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of proteasome activator complex IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
proteasome activator complex subunit 1
Names
11S regulator complex subunit alpha
PA28 alpha subunit
PA28alpha
REG-alpha
activator of multicatalytic protease subunit 1
protease (prosome, macropain) 28 subunit, alpha
proteasome (prosome, macropain) 28 subunit, alpha
proteasome activator 28 subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011189.1NP_035319.1  proteasome activator complex subunit 1

    See identical proteins and their annotated locations for NP_035319.1

    Status: PROVISIONAL

    Source sequence(s)
    D87909
    Consensus CDS
    CCDS36931.1
    UniProtKB/Swiss-Prot
    O35561, P97371, Q9D841
    UniProtKB/TrEMBL
    G3UXZ5, Q5HZK3
    Related
    ENSMUSP00000134735.2, ENSMUST00000174259.8
    Conserved Domains (2) summary
    pfam02251
    Location:868
    PA28_alpha; Proteasome activator pa28 alpha subunit
    pfam02252
    Location:104246
    PA28_beta; Proteasome activator pa28 beta subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55815951..55818984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)