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CORO1B coronin 1B [ Homo sapiens (human) ]

Gene ID: 57175, updated on 5-Sep-2021

Summary

Official Symbol
CORO1Bprovided by HGNC
Official Full Name
coronin 1Bprovided by HGNC
Primary source
HGNC:HGNC:2253
See related
Ensembl:ENSG00000172725 MIM:609849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CORONIN-2
Summary
Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility (Cai et al., 2005 [PubMed 16027158]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in prostate (RPKM 38.7), spleen (RPKM 34.9) and 25 other tissues See more
Orthologs
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Genomic context

See CORO1B in Genome Data Viewer
Location:
11q13.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (67435510..67443809, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67202981..67211280, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene carnosine synthase 1 Neighboring gene ribosomal protein S6 kinase B2 Neighboring gene protein tyrosine phosphatase receptor type C associated protein Neighboring gene G protein-coupled receptor 152 Neighboring gene calcium binding protein 4 Neighboring gene transmembrane protein 134 Neighboring gene aryl hydrocarbon receptor interacting protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp762I166

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Arp2/3 complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables Arp2/3 complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin filament binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cadherin binding HDA PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin filament branching IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin filament bundle assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to platelet-derived growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endothelial cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in endothelial cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of smooth muscle cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of lamellipodium morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of Arp2/3 complex-mediated actin nucleation IC
Inferred by Curator
more info
PubMed 
involved_in ruffle organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in wound healing IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
coronin-1B
Names
coronin, actin binding protein, 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001018070.3NP_001018080.1  coronin-1B

    See identical proteins and their annotated locations for NP_001018080.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AP003419, BC006449, DA061767
    Consensus CDS
    CCDS8164.1
    UniProtKB/Swiss-Prot
    Q9BR76
    UniProtKB/TrEMBL
    A0A024R5K1
    Related
    ENSP00000377471.1, ENST00000393893.5
    Conserved Domains (2) summary
    sd00039
    Location:3880
    7WD40; WD40 repeat [structural motif]
    cl25676
    Location:10485
    WD40_4; Type of WD40 repeat
  2. NM_020441.3NP_065174.1  coronin-1B

    See identical proteins and their annotated locations for NP_065174.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AP003419, BC006449
    Consensus CDS
    CCDS8164.1
    UniProtKB/Swiss-Prot
    Q9BR76
    UniProtKB/TrEMBL
    A0A024R5K1
    Related
    ENSP00000340211.5, ENST00000341356.10
    Conserved Domains (2) summary
    sd00039
    Location:3880
    7WD40; WD40 repeat [structural motif]
    cl25676
    Location:10485
    WD40_4; Type of WD40 repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    67435510..67443809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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