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Coro1b coronin, actin binding protein 1B [ Mus musculus (house mouse) ]

Gene ID: 23789, updated on 23-Jun-2021

Summary

Official Symbol
Coro1bprovided by MGI
Official Full Name
coronin, actin binding protein 1Bprovided by MGI
Primary source
MGI:MGI:1345963
See related
Ensembl:ENSMUSG00000024835
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Ubiquitous expression in colon adult (RPKM 222.9), large intestine adult (RPKM 168.1) and 28 other tissues See more
Orthologs
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Genomic context

See Coro1b in Genome Data Viewer
Location:
19 A; 19 3.85 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4198603..4204034)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4148611..4154035)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (4148663..4154035)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene calcium binding protein 4 Neighboring gene G protein-coupled receptor 152 Neighboring gene protein tyrosine phosphatase, receptor type, C polypeptide-associated protein Neighboring gene ribosomal protein S6 kinase, polypeptide 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Arp2/3 complex binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament branching ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to platelet-derived growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelial cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lamellipodium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smooth muscle cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lamellipodium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein kinase C signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to cell leading edge ISO
Inferred from Sequence Orthology
more info
 
involved_in ruffle organization ISO
Inferred from Sequence Orthology
more info
 
involved_in wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in actin filament ISO
Inferred from Sequence Orthology
more info
 
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
 
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
coronin-1B
Names
coronin 1b
coronin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011778.3NP_035908.1  coronin-1B

    See identical proteins and their annotated locations for NP_035908.1

    Status: VALIDATED

    Source sequence(s)
    AC109138
    Consensus CDS
    CCDS29418.1
    UniProtKB/Swiss-Prot
    Q9WUM3
    UniProtKB/TrEMBL
    A2RS22
    Related
    ENSMUSP00000008893.9, ENSMUST00000008893.9
    Conserved Domains (2) summary
    sd00039
    Location:3880
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:10480
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    4198603..4204034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531742.2XP_006531805.1  coronin-1B isoform X1

    See identical proteins and their annotated locations for XP_006531805.1

    UniProtKB/Swiss-Prot
    Q9WUM3
    UniProtKB/TrEMBL
    A2RS22
    Conserved Domains (2) summary
    sd00039
    Location:3880
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:10480
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_036161585.1XP_036017478.1  coronin-1B isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:4782
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:18347
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_036161586.1XP_036017479.1  coronin-1B isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:4782
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:18347
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_036161587.1XP_036017480.1  coronin-1B isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:4782
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:18347
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_006531741.4XP_006531804.1  coronin-1B isoform X1

    See identical proteins and their annotated locations for XP_006531804.1

    UniProtKB/Swiss-Prot
    Q9WUM3
    UniProtKB/TrEMBL
    A2RS22
    Conserved Domains (2) summary
    sd00039
    Location:3880
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:10480
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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