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CAMK1D calcium/calmodulin dependent protein kinase ID [ Homo sapiens (human) ]

Gene ID: 57118, updated on 24-Nov-2020

Summary

Official Symbol
CAMK1Dprovided by HGNC
Official Full Name
calcium/calmodulin dependent protein kinase IDprovided by HGNC
Primary source
HGNC:HGNC:19341
See related
Ensembl:ENSG00000183049 MIM:607957
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKLiK; CaM-K1; CaMKID
Summary
This gene is a member of the calcium/calmodulin-dependent protein kinase 1 family, a subfamily of the serine/threonine kinases. The encoded protein is a component of the calcium-regulated calmodulin-dependent protein kinase cascade. It has been associated with multiple processes including regulation of granulocyte function, activation of CREB-dependent gene transcription, aldosterone synthesis, differentiation and activation of neutrophil cells, and apoptosis of erythroleukemia cells. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jan 2015]
Expression
Broad expression in brain (RPKM 10.9), skin (RPKM 4.6) and 21 other tissues See more
Orthologs

Genomic context

See CAMK1D in Genome Data Viewer
Location:
10p13
Exon count:
18
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (12349514..12835545)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (12391583..12871735)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene FOXA motif-containing MPRA enhancer 241 Neighboring gene cell division cycle 123 Neighboring gene RNA, 7SL, cytoplasmic 198, pseudogene Neighboring gene RNA, U6atac small nuclear 39, pseudogene Neighboring gene uncharacterized LOC107984209 Neighboring gene microRNA 4480 Neighboring gene microRNA 4481 Neighboring gene microRNA 548q Neighboring gene uncharacterized LOC105376418 Neighboring gene 10p13 CCDC3 distal Alu-mediated recombination region Neighboring gene RNA, 5S ribosomal pseudogene 300 Neighboring gene coiled-coil domain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
GeneReviews: Not available
Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval.
GeneReviews: Not available
Genetic variants associated with disordered eating.
GeneReviews: Not available
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
GeneReviews: Not available
Identification of new genetic risk variants for type 2 diabetes.
GeneReviews: Not available
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of calcium/calmodulin-dependent protein kinase ID (CAMK1D) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40058

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of CREB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neutrophil chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of respiratory burst IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of granulocyte chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase type 1D
Names
CAMK1D/ANAPC5 fusion
CaM kinase ID
CamKI-like protein kinase
caM kinase I delta
caM-KI delta
caMKI delta
NP_001337961.1
NP_065130.1
NP_705718.1
XP_006717545.1
XP_006717546.1
XP_011517893.1
XP_011517894.1
XP_011517895.1
XP_011517896.1
XP_011517897.1
XP_016871927.1
XP_024303855.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351032.2NP_001337961.1  calcium/calmodulin-dependent protein kinase type 1D isoform 3

    Status: REVIEWED

    Source sequence(s)
    AA903749, AF286366, AK289393, AL391314, AL512783, BQ059621, HY156642
    Conserved Domains (1) summary
    cl21453
    Location:1215
    PKc_like; Protein Kinases, catalytic domain
  2. NM_020397.4NP_065130.1  calcium/calmodulin-dependent protein kinase type 1D isoform 1

    See identical proteins and their annotated locations for NP_065130.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks the 3' terminal exon used in variant 2, and its 3' terminal exon extends past a splice site that is used in variant 2. It encodes isoform 1, which has a shorter and distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AA903749, AF286366, AK289393, AL512783, BQ059621, HY168807
    Consensus CDS
    CCDS7092.1
    UniProtKB/Swiss-Prot
    Q8IU85
    UniProtKB/TrEMBL
    Q5SQQ7
    Related
    ENSP00000368122.1, ENST00000378845.5
    Conserved Domains (1) summary
    cd14168
    Location:12312
    STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta
  3. NM_153498.4NP_705718.1  calcium/calmodulin-dependent protein kinase type 1D isoform 2

    See identical proteins and their annotated locations for NP_705718.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AB081726, AK289393, AL512783, BC035745, BC073155, HY168807, KF510334
    Consensus CDS
    CCDS7091.1
    UniProtKB/Swiss-Prot
    Q8IU85
    UniProtKB/TrEMBL
    Q5SQQ7
    Related
    ENSP00000478874.1, ENST00000619168.4
    Conserved Domains (1) summary
    cd14168
    Location:12312
    STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    12349514..12835545
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717482.3XP_006717545.1  calcium/calmodulin-dependent protein kinase type 1D isoform X2

    Conserved Domains (1) summary
    cd14168
    Location:12312
    STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta
  2. XM_017016438.2XP_016871927.1  calcium/calmodulin-dependent protein kinase type 1D isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:1215
    PKc_like; Protein Kinases, catalytic domain
  3. XM_006717483.4XP_006717546.1  calcium/calmodulin-dependent protein kinase type 1D isoform X3

    See identical proteins and their annotated locations for XP_006717546.1

    Conserved Domains (1) summary
    cd14168
    Location:12312
    STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta
  4. XM_011519591.3XP_011517893.1  calcium/calmodulin-dependent protein kinase type 1D isoform X1

    Conserved Domains (1) summary
    cd14083
    Location:18265
    STKc_CaMKI; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I
  5. XM_024448087.1XP_024303855.1  calcium/calmodulin-dependent protein kinase type 1D isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:1215
    PKc_like; Protein Kinases, catalytic domain
  6. XM_011519595.3XP_011517897.1  calcium/calmodulin-dependent protein kinase type 1D isoform X6

    See identical proteins and their annotated locations for XP_011517897.1

    Related
    ENSP00000478861.1, ENST00000615792.1
    Conserved Domains (1) summary
    cl21453
    Location:1215
    PKc_like; Protein Kinases, catalytic domain
  7. XM_011519593.3XP_011517895.1  calcium/calmodulin-dependent protein kinase type 1D isoform X5

    Conserved Domains (2) summary
    smart00220
    Location:1205
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2238
    PKc_like; Protein Kinases, catalytic domain
  8. XM_011519592.3XP_011517894.1  calcium/calmodulin-dependent protein kinase type 1D isoform X4

    Conserved Domains (2) summary
    smart00220
    Location:6209
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:6242
    PKc_like; Protein Kinases, catalytic domain
  9. XM_011519594.3XP_011517896.1  calcium/calmodulin-dependent protein kinase type 1D isoform X7

    Conserved Domains (2) summary
    smart00220
    Location:1142
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1175
    PKc_like; Protein Kinases, catalytic domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_027322.1: Suppressed sequence

    Description
    NR_027322.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
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