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CAMK1D calcium/calmodulin dependent protein kinase ID [ Homo sapiens (human) ]

Gene ID: 57118, updated on 23-Nov-2023

Summary

Official Symbol
CAMK1Dprovided by HGNC
Official Full Name
calcium/calmodulin dependent protein kinase IDprovided by HGNC
Primary source
HGNC:HGNC:19341
See related
Ensembl:ENSG00000183049 MIM:607957; AllianceGenome:HGNC:19341
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKLiK; CaM-K1; CaMKID
Summary
This gene is a member of the calcium/calmodulin-dependent protein kinase 1 family, a subfamily of the serine/threonine kinases. The encoded protein is a component of the calcium-regulated calmodulin-dependent protein kinase cascade. It has been associated with multiple processes including regulation of granulocyte function, activation of CREB-dependent gene transcription, aldosterone synthesis, differentiation and activation of neutrophil cells, and apoptosis of erythroleukemia cells. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jan 2015]
Expression
Broad expression in brain (RPKM 10.9), skin (RPKM 4.6) and 21 other tissues See more
Orthologs
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Genomic context

See CAMK1D in Genome Data Viewer
Location:
10p13
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (12349547..12835545)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (12360834..12849903)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (12391546..12877545)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3037 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:12267705-12268640 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:12268641-12269574 Neighboring gene FOXA motif-containing MPRA enhancer 241 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2139 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:12306176-12306714 Neighboring gene cell division cycle 123 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12365022-12365522 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12365523-12366023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3039 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2141 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2143 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:12391861-12392360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3040 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2144 Neighboring gene RNA, 7SL, cytoplasmic 198, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12430241-12430740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12430790-12431290 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3041 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3042 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:12490405-12491604 Neighboring gene RNA, U6atac small nuclear 39, pseudogene Neighboring gene uncharacterized LOC107984209 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:12524423-12525029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3043 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3044 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12531623-12532583 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3045 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2146 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2147 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12594952-12595452 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:12595691-12595888 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3047 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12680729-12681229 Neighboring gene microRNA 4480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3048 Neighboring gene Sharpr-MPRA regulatory region 13393 Neighboring gene microRNA 4481 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2148 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:12781907-12782408 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:12782409-12782908 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:12808306-12808806 Neighboring gene microRNA 548q Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12830027-12830528 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12830529-12831028 Neighboring gene NANOG hESC enhancer GRCh37_chr10:12838401-12838902 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12845476-12845976 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12845977-12846477 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12849244-12849744 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:12860895-12861500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:12861501-12862105 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:12862106-12862710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:12891157-12891656 Neighboring gene uncharacterized LOC105376418 Neighboring gene 10p13 CCDC3 distal Alu-mediated recombination region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:12958041-12958581 Neighboring gene RNA, 5S ribosomal pseudogene 300 Neighboring gene coiled-coil domain containing 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:13042842-13043342 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:13043343-13043843 Neighboring gene 10p13 CCDC3 medial Alu-mediated recombination region Neighboring gene NANOG hESC enhancer GRCh37_chr10:13091983-13092484 Neighboring gene ribosomal protein L5 pseudogene 25

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
EBI GWAS Catalog
Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval.
EBI GWAS Catalog
Genetic variants associated with disordered eating.
EBI GWAS Catalog
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
EBI GWAS Catalog
Identification of new genetic risk variants for type 2 diabetes.
EBI GWAS Catalog
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of calcium/calmodulin-dependent protein kinase ID (CAMK1D) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ40058

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of CREB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neutrophil chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of respiratory burst IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of granulocyte chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase type 1D
Names
CAMK1D/ANAPC5 fusion
CaM kinase ID
CamKI-like protein kinase
caM kinase I delta
caM-KI delta
caMKI delta
NP_001337961.1
NP_065130.1
NP_705718.1
XP_006717545.1
XP_006717546.1
XP_011517893.1
XP_011517894.1
XP_011517895.1
XP_011517897.1
XP_047281493.1
XP_054222341.1
XP_054222342.1
XP_054222343.1
XP_054222344.1
XP_054222345.1
XP_054222346.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351032.2NP_001337961.1  calcium/calmodulin-dependent protein kinase type 1D isoform 3

    Status: REVIEWED

    Source sequence(s)
    AA903749, AF286366, AK289393, AL391314, AL512783, BQ059621, HY156642
    Conserved Domains (1) summary
    cl21453
    Location:1215
    PKc_like; Protein Kinases, catalytic domain
  2. NM_020397.4NP_065130.1  calcium/calmodulin-dependent protein kinase type 1D isoform 1

    See identical proteins and their annotated locations for NP_065130.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks the 3' terminal exon used in variant 2, and its 3' terminal exon extends past a splice site that is used in variant 2. It encodes isoform 1, which has a shorter and distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AA903749, AF286366, AK289393, AL512783, BQ059621, HY168807
    Consensus CDS
    CCDS7092.1
    UniProtKB/TrEMBL
    Q5SQQ7
    Related
    ENSP00000368122.1, ENST00000378845.5
    Conserved Domains (1) summary
    cd14168
    Location:12312
    STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta
  3. NM_153498.4NP_705718.1  calcium/calmodulin-dependent protein kinase type 1D isoform 2

    See identical proteins and their annotated locations for NP_705718.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AB081726, AK289393, AL512783, BC035745, BC073155, HY168807, KF510334
    Consensus CDS
    CCDS7091.1
    UniProtKB/Swiss-Prot
    B0YIY0, Q8IU85, Q9HD31
    Related
    ENSP00000478874.1, ENST00000619168.5
    Conserved Domains (1) summary
    cd14168
    Location:12312
    STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    12349547..12835545
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717483.5XP_006717546.1  calcium/calmodulin-dependent protein kinase type 1D isoform X3

    See identical proteins and their annotated locations for XP_006717546.1

    Conserved Domains (1) summary
    cd14168
    Location:12312
    STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta
  2. XM_006717482.4XP_006717545.1  calcium/calmodulin-dependent protein kinase type 1D isoform X2

    Conserved Domains (1) summary
    cd14168
    Location:12312
    STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta
  3. XM_047425537.1XP_047281493.1  calcium/calmodulin-dependent protein kinase type 1D isoform X6

  4. XM_011519591.4XP_011517893.1  calcium/calmodulin-dependent protein kinase type 1D isoform X1

    Conserved Domains (1) summary
    cd14083
    Location:18265
    STKc_CaMKI; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I
  5. XM_011519595.4XP_011517897.1  calcium/calmodulin-dependent protein kinase type 1D isoform X6

    See identical proteins and their annotated locations for XP_011517897.1

    Conserved Domains (1) summary
    cl21453
    Location:1215
    PKc_like; Protein Kinases, catalytic domain
  6. XM_011519593.4XP_011517895.1  calcium/calmodulin-dependent protein kinase type 1D isoform X5

    Conserved Domains (2) summary
    smart00220
    Location:1205
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:2238
    PKc_like; Protein Kinases, catalytic domain
  7. XM_011519592.4XP_011517894.1  calcium/calmodulin-dependent protein kinase type 1D isoform X4

    Conserved Domains (2) summary
    smart00220
    Location:6209
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:6242
    PKc_like; Protein Kinases, catalytic domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    12360834..12849903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366368.1XP_054222343.1  calcium/calmodulin-dependent protein kinase type 1D isoform X3

  2. XM_054366367.1XP_054222342.1  calcium/calmodulin-dependent protein kinase type 1D isoform X2

  3. XM_054366366.1XP_054222341.1  calcium/calmodulin-dependent protein kinase type 1D isoform X1

  4. XM_054366371.1XP_054222346.1  calcium/calmodulin-dependent protein kinase type 1D isoform X6

  5. XM_054366370.1XP_054222345.1  calcium/calmodulin-dependent protein kinase type 1D isoform X5

  6. XM_054366369.1XP_054222344.1  calcium/calmodulin-dependent protein kinase type 1D isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_027322.1: Suppressed sequence

    Description
    NR_027322.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.