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INTS12 integrator complex subunit 12 [ Homo sapiens (human) ]

Gene ID: 57117, updated on 7-Jun-2020

Summary

Official Symbol
INTS12provided by HGNC
Official Full Name
integrator complex subunit 12provided by HGNC
Primary source
HGNC:HGNC:25067
See related
Ensembl:ENSG00000138785 MIM:611355
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INT12; PHF22; SBBI22
Summary
INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in thyroid (RPKM 6.3), bone marrow (RPKM 5.9) and 25 other tissues See more
Orthologs

Genomic context

See INTS12 in Genome Data Viewer
Location:
4q24
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (105682627..105708725, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (106603784..106629881, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377352 Neighboring gene ARHGEF38 intronic transcript 1 Neighboring gene Rho guanine nucleotide exchange factor 38 Neighboring gene glutathione S-transferase C-terminal domain containing Neighboring gene uncharacterized LOC107986190 Neighboring gene GSTCD antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Gene network analysis in a pediatric cohort identifies novel lung function genes.
NHGRI GWA Catalog
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
NHGRI GWA Catalog
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of integrator complex subunit 12 (INTS12; SBBI22) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
snRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
snRNA transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrator complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
integrator complex subunit 12
Names
PHD finger protein 22
hypothetical nuclear factor SBBI22

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142471.1NP_001135943.1  integrator complex subunit 12

    See identical proteins and their annotated locations for NP_001135943.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) omits an alternate exon in the 5'UTR. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK314939, BK005729
    Consensus CDS
    CCDS3671.1
    UniProtKB/Swiss-Prot
    Q96CB8
    UniProtKB/TrEMBL
    A0A024RDK4
    Related
    ENSP00000415433.2, ENST00000451321.6
    Conserved Domains (1) summary
    cd15501
    Location:161212
    PHD_Int12; PHD finger found in integrator complex subunit 12 (Int12) and similar proteins
  2. NM_020395.4NP_065128.2  integrator complex subunit 12

    See identical proteins and their annotated locations for NP_065128.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) includes an alternate exon in the 5'UTR. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK314939, BC014442
    Consensus CDS
    CCDS3671.1
    UniProtKB/Swiss-Prot
    Q96CB8
    UniProtKB/TrEMBL
    A0A024RDK4
    Related
    ENSP00000340737.5, ENST00000340139.10
    Conserved Domains (1) summary
    cd15501
    Location:161212
    PHD_Int12; PHD finger found in integrator complex subunit 12 (Int12) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    105682627..105708725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532145.2XP_011530447.1  integrator complex subunit 12 isoform X1

    See identical proteins and their annotated locations for XP_011530447.1

    UniProtKB/Swiss-Prot
    Q96CB8
    UniProtKB/TrEMBL
    A0A024RDK4
    Conserved Domains (1) summary
    cd15501
    Location:161212
    PHD_Int12; PHD finger found in integrator complex subunit 12 (Int12) and similar proteins
  2. XM_005263148.5XP_005263205.1  integrator complex subunit 12 isoform X1

    See identical proteins and their annotated locations for XP_005263205.1

    UniProtKB/Swiss-Prot
    Q96CB8
    UniProtKB/TrEMBL
    A0A024RDK4
    Related
    ENSP00000378221.1, ENST00000394735.5
    Conserved Domains (1) summary
    cd15501
    Location:161212
    PHD_Int12; PHD finger found in integrator complex subunit 12 (Int12) and similar proteins
  3. XM_011532143.2XP_011530445.1  integrator complex subunit 12 isoform X1

    See identical proteins and their annotated locations for XP_011530445.1

    UniProtKB/Swiss-Prot
    Q96CB8
    UniProtKB/TrEMBL
    A0A024RDK4
    Conserved Domains (1) summary
    cd15501
    Location:161212
    PHD_Int12; PHD finger found in integrator complex subunit 12 (Int12) and similar proteins

RNA

  1. XR_001741294.1 RNA Sequence

  2. XR_001741293.1 RNA Sequence

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