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Ints12 integrator complex subunit 12 [ Mus musculus (house mouse) ]

Gene ID: 71793, updated on 30-Apr-2024

Summary

Official Symbol
Ints12provided by MGI
Official Full Name
integrator complex subunit 12provided by MGI
Primary source
MGI:MGI:1919043
See related
Ensembl:ENSMUSG00000028016 AllianceGenome:MGI:1919043
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Phf22; int12; 1110020M19Rik; 2810027J24Rik; 4930529N21Rik; A230056J18Rik
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in snRNA 3'-end processing. Predicted to be located in nucleus. Predicted to be part of integrator complex. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and liver and biliary system. Orthologous to human INTS12 (integrator complex subunit 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 6.0), placenta adult (RPKM 4.7) and 26 other tissues See more
Orthologs
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Genomic context

See Ints12 in Genome Data Viewer
Location:
3 G3; 3 61.56 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (132797616..132816749)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (133091855..133110988)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene nephronectin Neighboring gene predicted gene, 23196 Neighboring gene glutathione S-transferase, C-terminal domain containing Neighboring gene TIP41, TOR signalling pathway regulator-like pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6130 Neighboring gene STARR-positive B cell enhancer ABC_E9573 Neighboring gene STARR-positive B cell enhancer mm9_chr3:132754721-132755022 Neighboring gene STARR-positive B cell enhancer ABC_E11218 Neighboring gene Rho guanine nucleotide exchange factor 38 Neighboring gene STARR-seq mESC enhancer starr_09022 Neighboring gene predicted gene, 52616 Neighboring gene STARR-positive B cell enhancer ABC_E10215 Neighboring gene STARR-positive B cell enhancer ABC_E4594 Neighboring gene STARR-positive B cell enhancer ABC_E4595 Neighboring gene STARR-positive B cell enhancer ABC_E9574 Neighboring gene STARR-seq mESC enhancer starr_09023 Neighboring gene pyrophosphatase (inorganic) 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in snRNA processing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of integrator complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
integrator complex subunit 12
Names
PHD finger protein 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027927.4NP_082203.1  integrator complex subunit 12

    See identical proteins and their annotated locations for NP_082203.1

    Status: VALIDATED

    Source sequence(s)
    AK003874, AK015941, BQ174479, BX521801, BY155830, BY273040
    Consensus CDS
    CCDS17848.1
    UniProtKB/Swiss-Prot
    Q3U2Q5, Q921U2, Q9D168
    Related
    ENSMUSP00000029650.9, ENSMUST00000029650.9
    Conserved Domains (1) summary
    cd15501
    Location:160211
    PHD_Int12; PHD finger found in integrator complex subunit 12 (Int12) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    132797616..132816749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)