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OTUD7B OTU deubiquitinase 7B [ Homo sapiens (human) ]

Gene ID: 56957, updated on 7-Jul-2024

Summary

Official Symbol
OTUD7Bprovided by HGNC
Official Full Name
OTU deubiquitinase 7Bprovided by HGNC
Primary source
HGNC:HGNC:16683
See related
Ensembl:ENSG00000264522 MIM:611748; AllianceGenome:HGNC:16683
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZA20D1; CEZANNE
Summary
Enables Lys48-specific deubiquitinase activity and thiol-dependent deubiquitinase. Involved in several processes, including negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of macromolecule metabolic process; and protein deubiquitination. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in fat (RPKM 4.7), testis (RPKM 4.3) and 25 other tissues See more
Orthologs
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Genomic context

See OTUD7B in Genome Data Viewer
Location:
1q21.2
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (149937812..150067653, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (149062296..149192273, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (149909705..149982675, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1666 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:149908038-149908562 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1667 Neighboring gene splicing factor 3b subunit 4 Neighboring gene myotubularin related protein 11 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:149981420-149982302 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1292 Neighboring gene uncharacterized LOC124904413 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:149989091-149989750 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:149989751-149990408 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1293 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1669 Neighboring gene ribosomal protein L6 pseudogene 31 Neighboring gene vacuolar protein sorting 45 homolog Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:150122046-150122546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:150131051-150131552 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1296 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1670 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1297 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1298 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1672 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1673 Neighboring gene pleckstrin homology domain containing O1 Neighboring gene long intergenic non-protein coding RNA 2988 Neighboring gene Sharpr-MPRA regulatory region 9169

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables K48-linked deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables K48-linked deubiquitinase activity TAS
Traceable Author Statement
more info
 
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables cysteine-type peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in mucosal immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein localization to nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K11-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein K11-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K48-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein K48-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K48-linked deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein K63-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein K63-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
OTU domain-containing protein 7B
Names
OTU domain containing 7B
cellular zinc finger anti-NF-kappa-B protein
cellular zinc finger anti-NF-kappaB Cezanne
zinc finger A20 domain-containing protein 1
zinc finger protein Cezanne
zinc finger, A20 domain containing 1
NP_064590.2
XP_011508084.1
XP_011508086.1
XP_011508087.1
XP_011508090.1
XP_016857339.1
XP_047281668.1
XP_047281671.1
XP_047281672.1
XP_047281673.1
XP_047281676.1
XP_047281677.1
XP_054193734.1
XP_054193735.1
XP_054193736.1
XP_054193737.1
XP_054193738.1
XP_054193739.1
XP_054193740.1
XP_054193741.1
XP_054193742.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020205.4NP_064590.2  OTU domain-containing protein 7B

    See identical proteins and their annotated locations for NP_064590.2

    Status: VALIDATED

    Source sequence(s)
    AC244033, BC015719, BC072681, BP321045, T51077
    Consensus CDS
    CCDS72903.1
    UniProtKB/Swiss-Prot
    B7Z643, D3DUZ8, Q5SZ60, Q6GQQ9, Q8WWA7, Q9NQ53, Q9UFF4
    Related
    ENSP00000462729.1, ENST00000581312.6
    Conserved Domains (4) summary
    cd14347
    Location:446
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam07271
    Location:667797
    Cytadhesin_P30; Cytadhesin P30/P32
    pfam01754
    Location:801823
    zf-A20; A20-like zinc finger
    cl19932
    Location:189359
    OTU; OTU-like cysteine protease

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    149937812..150067653 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425721.1XP_047281677.1  OTU domain-containing protein 7B isoform X2

    UniProtKB/Swiss-Prot
    B7Z643, D3DUZ8, Q5SZ60, Q6GQQ9, Q8WWA7, Q9NQ53, Q9UFF4
  2. XM_047425716.1XP_047281672.1  OTU domain-containing protein 7B isoform X1

  3. XM_047425712.1XP_047281668.1  OTU domain-containing protein 7B isoform X1

  4. XM_047425720.1XP_047281676.1  OTU domain-containing protein 7B isoform X2

    UniProtKB/Swiss-Prot
    B7Z643, D3DUZ8, Q5SZ60, Q6GQQ9, Q8WWA7, Q9NQ53, Q9UFF4
  5. XM_011509784.4XP_011508086.1  OTU domain-containing protein 7B isoform X1

    See identical proteins and their annotated locations for XP_011508086.1

    Conserved Domains (3) summary
    cd14347
    Location:446
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:810832
    zf-A20; A20-like zinc finger
    cl19932
    Location:189359
    OTU; OTU-like cysteine protease
  6. XM_011509782.2XP_011508084.1  OTU domain-containing protein 7B isoform X1

    See identical proteins and their annotated locations for XP_011508084.1

    Conserved Domains (3) summary
    cd14347
    Location:446
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:810832
    zf-A20; A20-like zinc finger
    cl19932
    Location:189359
    OTU; OTU-like cysteine protease
  7. XM_047425715.1XP_047281671.1  OTU domain-containing protein 7B isoform X1

  8. XM_047425717.1XP_047281673.1  OTU domain-containing protein 7B isoform X2

    UniProtKB/Swiss-Prot
    B7Z643, D3DUZ8, Q5SZ60, Q6GQQ9, Q8WWA7, Q9NQ53, Q9UFF4
  9. XM_011509785.3XP_011508087.1  OTU domain-containing protein 7B isoform X1

    See identical proteins and their annotated locations for XP_011508087.1

    Conserved Domains (3) summary
    cd14347
    Location:446
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:810832
    zf-A20; A20-like zinc finger
    cl19932
    Location:189359
    OTU; OTU-like cysteine protease
  10. XM_017001850.2XP_016857339.1  OTU domain-containing protein 7B isoform X4

  11. XM_011509788.3XP_011508090.1  OTU domain-containing protein 7B isoform X3

    See identical proteins and their annotated locations for XP_011508090.1

    Conserved Domains (2) summary
    pfam01754
    Location:731753
    zf-A20; A20-like zinc finger
    cl19932
    Location:110280
    OTU; OTU-like cysteine protease

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    149062296..149192273 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337764.1XP_054193739.1  OTU domain-containing protein 7B isoform X2

    UniProtKB/Swiss-Prot
    B7Z643, D3DUZ8, Q5SZ60, Q6GQQ9, Q8WWA7, Q9NQ53, Q9UFF4
  2. XM_054337760.1XP_054193735.1  OTU domain-containing protein 7B isoform X1

  3. XM_054337761.1XP_054193736.1  OTU domain-containing protein 7B isoform X1

  4. XM_054337763.1XP_054193738.1  OTU domain-containing protein 7B isoform X2

    UniProtKB/Swiss-Prot
    B7Z643, D3DUZ8, Q5SZ60, Q6GQQ9, Q8WWA7, Q9NQ53, Q9UFF4
  5. XM_054337759.1XP_054193734.1  OTU domain-containing protein 7B isoform X1

  6. XM_054337762.1XP_054193737.1  OTU domain-containing protein 7B isoform X1

  7. XM_054337765.1XP_054193740.1  OTU domain-containing protein 7B isoform X2

    UniProtKB/Swiss-Prot
    B7Z643, D3DUZ8, Q5SZ60, Q6GQQ9, Q8WWA7, Q9NQ53, Q9UFF4
  8. XM_054337767.1XP_054193742.1  OTU domain-containing protein 7B isoform X4

  9. XM_054337766.1XP_054193741.1  OTU domain-containing protein 7B isoform X3