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OTUD7B OTU deubiquitinase 7B [ Homo sapiens (human) ]

Gene ID: 56957, updated on 7-Oct-2018

Summary

Official Symbol
OTUD7Bprovided by HGNC
Official Full Name
OTU deubiquitinase 7Bprovided by HGNC
Primary source
HGNC:HGNC:16683
See related
Ensembl:ENSG00000264522 MIM:611748; Vega:OTTHUMG00000012291
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZA20D1; CEZANNE
Expression
Ubiquitous expression in fat (RPKM 4.7), testis (RPKM 4.3) and 25 other tissues See more
Orthologs

Genomic context

See OTUD7B in Genome Data Viewer
Location:
1q21.2
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (149940330..150010776, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (149912229..149982686, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene splicing factor 3b subunit 4 Neighboring gene myotubularin related protein 11 Neighboring gene uncharacterized LOC105371427 Neighboring gene ribosomal protein L6 pseudogene Neighboring gene vacuolar protein sorting 45 homolog

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Pathways from BioSystems

  • Death Receptor Signalling, organism-specific biosystem (from REACTOME)
    Death Receptor Signalling, organism-specific biosystemThe death receptors, all cell-surface receptors, begin the process of caspase activation. The common feature of these type 1 transmembrane proteins is the "death-domain" a conserved cytoplasmic motif...
  • Deubiquitination, organism-specific biosystem (from REACTOME)
    Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Ovarian tumor domain proteases, organism-specific biosystem (from REACTOME)
    Ovarian tumor domain proteases, organism-specific biosystemHumans have 16 Overian tumour domain (OTU) family DUBs that can be evolutionally divided into three classes, the OTUs, the Otubains (OTUBs), and the A20-like OTUs (Komander et al. 2009). OTU family ...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Regulation of TNFR1 signaling, organism-specific biosystem (from REACTOME)
    Regulation of TNFR1 signaling, organism-specific biosystemTumor necrosis factor-alpha (TNFalpha) is an inflammatory cytokine, that activates either cell survival (e.g.,inflammation, proliferation) or cell death upon association with TNF receptor 1 (TNFR1). ...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • TNF alpha Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TNF alpha Signaling Pathway, organism-specific biosystemTumor necrosis factor alpha (TNF?) is a proinflammatory cytokine involved in various biological processes including regulation of cell proliferation, differentiation, apoptosis and immune response. T...
  • TNF signaling, organism-specific biosystem (from REACTOME)
    TNF signaling, organism-specific biosystemThe inflammatory cytokine tumor necrosis factor alpha (TNF-alpha) is expressed in immune and nonimmune cell types including macrophages, T cells, mast cells, granulocytes, natural killer (NK) cells, ...
  • TNFR1-induced NFkappaB signaling pathway, organism-specific biosystem (from REACTOME)
    TNFR1-induced NFkappaB signaling pathway, organism-specific biosystemActivation of tumor necrosis factor receptor 1 (TNFR1) can trigger multiple signal transduction pathways to induce inflammation, cell proliferation, survival or cell death (Ward C et al. 1999; Michea...
  • TNFR1-induced proapoptotic signaling, organism-specific biosystem (from REACTOME)
    TNFR1-induced proapoptotic signaling, organism-specific biosystemActivation of tumor necrosis factor receptor 1 (TNFR1) can trigger multiple signal transduction pathways to induce cell survival or cell death (Ward C et al. 1999; Micheau O and Tschopp J 2003; Wider...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Lys48-specific deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Lys48-specific deubiquitinase activity TAS
Traceable Author Statement
more info
 
cysteine-type peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IDA
Inferred from Direct Assay
more info
PubMed 
thiol-dependent ubiquitinyl hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
mucosal immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein localization to nucleus IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
protein K11-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K11-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein K48-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K48-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein K48-linked deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
protein K63-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K63-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein deubiquitination involved in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
OTU domain-containing protein 7B
Names
OTU domain containing 7B
cellular zinc finger anti-NF-kappa-B protein
cellular zinc finger anti-NF-kappaB Cezanne
zinc finger A20 domain-containing protein 1
zinc finger protein Cezanne
zinc finger, A20 domain containing 1
NP_064590.2
XP_011508084.1
XP_011508086.1
XP_011508087.1
XP_011508088.1
XP_011508089.1
XP_011508090.1
XP_016857339.1
XP_016857340.1
XP_024304284.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020205.3NP_064590.2  OTU domain-containing protein 7B

    See identical proteins and their annotated locations for NP_064590.2

    Status: VALIDATED

    Source sequence(s)
    AC244033, BC015719, BC072681, BP321045, T51077
    Consensus CDS
    CCDS72903.1
    UniProtKB/Swiss-Prot
    Q6GQQ9
    Related
    ENSP00000462729.1, OTTHUMP00000275813, ENST00000581312.5, OTTHUMT00000034146
    Conserved Domains (4) summary
    cd14347
    Location:446
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam07271
    Location:667797
    Cytadhesin_P30; Cytadhesin P30/P32
    pfam01754
    Location:801823
    zf-A20; A20-like zinc finger
    cl19932
    Location:189359
    OTU; OTU-like cysteine protease

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    149940330..150010776 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448516.1XP_024304284.1  OTU domain-containing protein 7B isoform X4

    Conserved Domains (3) summary
    pfam07271
    Location:547677
    Cytadhesin_P30; Cytadhesin P30/P32
    pfam01754
    Location:681703
    zf-A20; A20-like zinc finger
    cl19932
    Location:60230
    OTU; OTU-like cysteine protease
  2. XM_017001851.2XP_016857340.1  OTU domain-containing protein 7B isoform X5

  3. XM_011509784.3XP_011508086.1  OTU domain-containing protein 7B isoform X1

    See identical proteins and their annotated locations for XP_011508086.1

    Conserved Domains (3) summary
    cd14347
    Location:446
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:810832
    zf-A20; A20-like zinc finger
    cl19932
    Location:189359
    OTU; OTU-like cysteine protease
  4. XM_011509788.2XP_011508090.1  OTU domain-containing protein 7B isoform X2

    See identical proteins and their annotated locations for XP_011508090.1

    Conserved Domains (2) summary
    pfam01754
    Location:731753
    zf-A20; A20-like zinc finger
    cl19932
    Location:110280
    OTU; OTU-like cysteine protease
  5. XM_017001850.1XP_016857339.1  OTU domain-containing protein 7B isoform X3

  6. XM_011509786.1XP_011508088.1  OTU domain-containing protein 7B isoform X2

    See identical proteins and their annotated locations for XP_011508088.1

    Conserved Domains (2) summary
    pfam01754
    Location:731753
    zf-A20; A20-like zinc finger
    cl19932
    Location:110280
    OTU; OTU-like cysteine protease
  7. XM_011509782.1XP_011508084.1  OTU domain-containing protein 7B isoform X1

    See identical proteins and their annotated locations for XP_011508084.1

    Conserved Domains (3) summary
    cd14347
    Location:446
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:810832
    zf-A20; A20-like zinc finger
    cl19932
    Location:189359
    OTU; OTU-like cysteine protease
  8. XM_011509785.2XP_011508087.1  OTU domain-containing protein 7B isoform X1

    See identical proteins and their annotated locations for XP_011508087.1

    Conserved Domains (3) summary
    cd14347
    Location:446
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:810832
    zf-A20; A20-like zinc finger
    cl19932
    Location:189359
    OTU; OTU-like cysteine protease
  9. XM_011509787.1XP_011508089.1  OTU domain-containing protein 7B isoform X2

    See identical proteins and their annotated locations for XP_011508089.1

    Conserved Domains (2) summary
    pfam01754
    Location:731753
    zf-A20; A20-like zinc finger
    cl19932
    Location:110280
    OTU; OTU-like cysteine protease
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