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Otud7b OTU domain containing 7B [ Mus musculus (house mouse) ]

Gene ID: 229603, updated on 8-Dec-2022

Summary

Official Symbol
Otud7bprovided by MGI
Official Full Name
OTU domain containing 7Bprovided by MGI
Primary source
MGI:MGI:2654703
See related
Ensembl:ENSMUSG00000038495 AllianceGenome:MGI:2654703
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Za20d1; CEZANNE; Trabid2; 2900060B22Rik; 4930463P07Rik
Summary
Enables K63-linked polyubiquitin modification-dependent protein binding activity and thiol-dependent deubiquitinase. Involved in several processes, including negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of transcription by RNA polymerase II; and protein K48-linked deubiquitination. Acts upstream of or within in utero embryonic development and protein deubiquitination. Located in cytoplasm. Orthologous to human OTUD7B (OTU deubiquitinase 7B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 8.7), lung adult (RPKM 6.7) and 28 other tissues See more
Orthologs
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Genomic context

See Otud7b in Genome Data Viewer
Location:
3; 3 F2.1
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96011759..96068446)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96104504..96161129)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 45 Neighboring gene predicted gene, 54210 Neighboring gene predicted gene, 30044 Neighboring gene myotubularin related protein 11 Neighboring gene predicted gene, 22027 Neighboring gene splicing factor 3b, subunit 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables K48-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables K63-linked polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type deubiquitinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type peptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mucosal immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K11-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein K11-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K48-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein K48-linked deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein K48-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K63-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein K63-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
OTU domain-containing protein 7B
Names
TRAF binding domain containing 2
cellular zinc finger anti-NF-kappa-B protein
zinc finger A20 domain-containing protein 1
zinc finger protein Cezanne
zinc finger, A20 domain containing 1
NP_001020784.1
NP_001020785.1
XP_006501448.1
XP_006501449.1
XP_006501452.1
XP_017175035.1
XP_017175037.1
XP_030108444.1
XP_030108445.1
XP_036018961.1
XP_036018962.1
XP_036018963.1
XP_036018964.1
XP_036018965.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025613.1NP_001020784.1  OTU domain-containing protein 7B

    See identical proteins and their annotated locations for NP_001020784.1

    Status: VALIDATED

    Source sequence(s)
    AC092094, AK044701, BB596613
    Consensus CDS
    CCDS17629.1
    UniProtKB/Swiss-Prot
    B2RUR8, Q8CFS0
    Related
    ENSMUSP00000088291.3, ENSMUST00000090785.9
    Conserved Domains (3) summary
    cd14347
    Location:446
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:798820
    zf-A20; A20-like zinc finger
    cl19932
    Location:189359
    OTU; OTU-like cysteine protease
  2. NM_001025614.1NP_001020785.1  OTU domain-containing protein 7B

    See identical proteins and their annotated locations for NP_001020785.1

    Status: VALIDATED

    Source sequence(s)
    AC092094, AK044701, BB596613
    Consensus CDS
    CCDS17629.1
    UniProtKB/Swiss-Prot
    B2RUR8, Q8CFS0
    Related
    ENSMUSP00000046413.6, ENSMUST00000035519.12
    Conserved Domains (3) summary
    cd14347
    Location:446
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:798820
    zf-A20; A20-like zinc finger
    cl19932
    Location:189359
    OTU; OTU-like cysteine protease

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    96011759..96068446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252585.2XP_030108445.1  OTU domain-containing protein 7B isoform X2

    Conserved Domains (2) summary
    pfam01754
    Location:706728
    zf-A20; A20-like zinc finger
    cl19932
    Location:97267
    OTU; OTU-like cysteine protease
  2. XM_036163070.1XP_036018963.1  OTU domain-containing protein 7B isoform X1

    UniProtKB/Swiss-Prot
    Q8CFS0
    Conserved Domains (3) summary
    cd14347
    Location:446
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:798820
    zf-A20; A20-like zinc finger
    cl19932
    Location:189359
    OTU; OTU-like cysteine protease
  3. XM_030252584.2XP_030108444.1  OTU domain-containing protein 7B isoform X2

    Conserved Domains (2) summary
    pfam01754
    Location:706728
    zf-A20; A20-like zinc finger
    cl19932
    Location:97267
    OTU; OTU-like cysteine protease
  4. XM_017319548.3XP_017175037.1  OTU domain-containing protein 7B isoform X2

    Conserved Domains (2) summary
    pfam01754
    Location:706728
    zf-A20; A20-like zinc finger
    cl19932
    Location:97267
    OTU; OTU-like cysteine protease
  5. XM_036163068.1XP_036018961.1  OTU domain-containing protein 7B isoform X1

    UniProtKB/Swiss-Prot
    Q8CFS0
    Conserved Domains (3) summary
    cd14347
    Location:446
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:798820
    zf-A20; A20-like zinc finger
    cl19932
    Location:189359
    OTU; OTU-like cysteine protease
  6. XM_006501385.4XP_006501448.1  OTU domain-containing protein 7B isoform X1

    See identical proteins and their annotated locations for XP_006501448.1

    UniProtKB/Swiss-Prot
    B2RUR8, Q8CFS0
    Conserved Domains (3) summary
    cd14347
    Location:446
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:798820
    zf-A20; A20-like zinc finger
    cl19932
    Location:189359
    OTU; OTU-like cysteine protease
  7. XM_036163069.1XP_036018962.1  OTU domain-containing protein 7B isoform X2

    Conserved Domains (2) summary
    pfam01754
    Location:706728
    zf-A20; A20-like zinc finger
    cl19932
    Location:97267
    OTU; OTU-like cysteine protease
  8. XM_006501389.4XP_006501452.1  OTU domain-containing protein 7B isoform X1

    See identical proteins and their annotated locations for XP_006501452.1

    UniProtKB/Swiss-Prot
    B2RUR8, Q8CFS0
    Conserved Domains (3) summary
    cd14347
    Location:446
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:798820
    zf-A20; A20-like zinc finger
    cl19932
    Location:189359
    OTU; OTU-like cysteine protease
  9. XM_006501386.3XP_006501449.1  OTU domain-containing protein 7B isoform X1

    See identical proteins and their annotated locations for XP_006501449.1

    UniProtKB/Swiss-Prot
    B2RUR8, Q8CFS0
    Related
    ENSMUSP00000096449.3, ENSMUST00000098849.3
    Conserved Domains (3) summary
    cd14347
    Location:446
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:798820
    zf-A20; A20-like zinc finger
    cl19932
    Location:189359
    OTU; OTU-like cysteine protease
  10. XM_036163071.1XP_036018964.1  OTU domain-containing protein 7B isoform X2

    Conserved Domains (2) summary
    pfam01754
    Location:706728
    zf-A20; A20-like zinc finger
    cl19932
    Location:97267
    OTU; OTU-like cysteine protease
  11. XM_036163072.1XP_036018965.1  OTU domain-containing protein 7B isoform X2

    Conserved Domains (2) summary
    pfam01754
    Location:706728
    zf-A20; A20-like zinc finger
    cl19932
    Location:97267
    OTU; OTU-like cysteine protease
  12. XM_017319546.1XP_017175035.1  OTU domain-containing protein 7B isoform X1

    UniProtKB/Swiss-Prot
    B2RUR8, Q8CFS0
    Conserved Domains (3) summary
    cd14347
    Location:446
    UBA_Cezanne_like; UBA-like domain found in OTU domain-containing proteins OTU7A, OTU7B and similar proteins
    pfam01754
    Location:798820
    zf-A20; A20-like zinc finger
    cl19932
    Location:189359
    OTU; OTU-like cysteine protease