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ENY2 ENY2 transcription and export complex 2 subunit [ Homo sapiens (human) ]

Gene ID: 56943, updated on 20-Mar-2019

Summary

Official Symbol
ENY2provided by HGNC
Official Full Name
ENY2 transcription and export complex 2 subunitprovided by HGNC
Primary source
HGNC:HGNC:24449
See related
Ensembl:ENSG00000120533
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DC6; Sus1; e(y)2
Expression
Ubiquitous expression in kidney (RPKM 15.2), bone marrow (RPKM 14.0) and 25 other tissues See more
Orthologs

Genomic context

See ENY2 in Genome Data Viewer
Location:
8q23.1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (109334323..109345960)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (110346552..110358189)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene thyrotropin releasing hormone receptor Neighboring gene NudC domain containing 1 Neighboring gene PKHD1 like 1 Neighboring gene suppressor of cytokine signaling 5 pseudogene Neighboring gene mitogen-activated protein kinase 6 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
    Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
  • Chromatin organization, organism-specific biosystem (from REACTOME)
    Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
  • HATs acetylate histones, organism-specific biosystem (from REACTOME)
    HATs acetylate histones, organism-specific biosystemHistone acetyltransferases (HATs) involved in histone modifications are referred to as A-type or nuclear HATs. They can be grouped into at least four families based on sequence conservation within th...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20480

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear receptor transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
histone deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of insulin secretion involved in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
poly(A)+ mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription elongation from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
DUBm complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DUBm complex IDA
Inferred from Direct Assay
more info
PubMed 
SAGA complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SAGA complex IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nuclear pore nuclear basket IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
transcription export complex 2 IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcription and mRNA export factor ENY2
Names
enhancer of yellow 2 homolog
enhancer of yellow 2 transcription factor homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193557.1NP_001180486.1  transcription and mRNA export factor ENY2 isoform 2

    See identical proteins and their annotated locations for NP_001180486.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site, which results in the use of a downstream, in-frame, start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AK095651, BU737295, DA548665, DB168034
    Consensus CDS
    CCDS55270.1
    UniProtKB/Swiss-Prot
    Q9NPA8
    Related
    ENSP00000429713.1, ENST00000521662.5
    Conserved Domains (1) summary
    pfam10163
    Location:990
    EnY2; Transcription factor e(y)2
  2. NM_020189.6NP_064574.1  transcription and mRNA export factor ENY2 isoform 1

    See identical proteins and their annotated locations for NP_064574.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AF173296, AK095651, BU737295
    Consensus CDS
    CCDS43762.1
    UniProtKB/Swiss-Prot
    Q9NPA8
    UniProtKB/TrEMBL
    A0A024R9D9
    Related
    ENSP00000429986.1, ENST00000521688.5
    Conserved Domains (1) summary
    pfam10163
    Location:1495
    EnY2; Transcription factor e(y)2

RNA

  1. NR_036471.1 RNA Sequence

    Status: VALIDATED

    Description
    This variant (3) uses a different splice site in the 3' end, compared to variant 1. It is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK095651, BU737295, DA762166, DB168034
  2. NR_036472.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses a different splice site in the 3' end, compared to variant 1. It is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK095651, BU737295, DB168034
    Related
    ENST00000517311.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    109334323..109345960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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