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ENY2 ENY2 transcription and export complex 2 subunit [ Homo sapiens (human) ]

Gene ID: 56943, updated on 8-Dec-2022

Summary

Official Symbol
ENY2provided by HGNC
Official Full Name
ENY2 transcription and export complex 2 subunitprovided by HGNC
Primary source
HGNC:HGNC:24449
See related
Ensembl:ENSG00000120533 MIM:619015; AllianceGenome:HGNC:24449
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DC6; Sus1; e(y)2
Summary
Enables nuclear receptor coactivator activity. Involved in histone deubiquitination; poly(A)+ mRNA export from nucleus; and positive regulation of transcription, DNA-templated. Located in mitochondrion and nucleoplasm. Part of nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney (RPKM 15.2), bone marrow (RPKM 14.0) and 25 other tissues See more
Orthologs
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Genomic context

See ENY2 in Genome Data Viewer
Location:
8q23.1
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (109334347..109345954)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (110462889..110474496)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (110346576..110358183)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene thyrotropin releasing hormone receptor Neighboring gene NudC domain containing 1 Neighboring gene PKHD1 like 1 Neighboring gene suppressor of cytokine signaling 5 pseudogene Neighboring gene mitogen-activated protein kinase 6 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20480

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear receptor coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in histone H3 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone H3 acetylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in histone deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in monoubiquitinated histone H2A deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in monoubiquitinated histone H2A deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in monoubiquitinated histone deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in monoubiquitinated histone deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in poly(A)+ mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of RNA splicing NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transcription elongation by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of DUBm complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of DUBm complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SAGA complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SAGA complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SAGA complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 
part_of nuclear pore nuclear basket IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
part_of transcription export complex 2 IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription factor TFTC complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
transcription and mRNA export factor ENY2
Names
enhancer of yellow 2 homolog
enhancer of yellow 2 transcription factor homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193557.2NP_001180486.1  transcription and mRNA export factor ENY2 isoform 2

    See identical proteins and their annotated locations for NP_001180486.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site, which results in the use of a downstream, in-frame, start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AK095651, BU737295, DA548665, DB168034
    Consensus CDS
    CCDS55270.1
    UniProtKB/Swiss-Prot
    Q9NPA8
    Related
    ENSP00000429713.1, ENST00000521662.5
    Conserved Domains (1) summary
    pfam10163
    Location:1189
    EnY2; Transcription factor e(y)2
  2. NM_020189.6NP_064574.1  transcription and mRNA export factor ENY2 isoform 1

    See identical proteins and their annotated locations for NP_064574.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AF173296, AK095651, BU737295
    Consensus CDS
    CCDS43762.1
    UniProtKB/Swiss-Prot
    G3V117, Q9NPA8
    UniProtKB/TrEMBL
    A0A024R9D9
    Related
    ENSP00000429986.1, ENST00000521688.6
    Conserved Domains (1) summary
    pfam10163
    Location:1694
    EnY2; Transcription factor e(y)2

RNA

  1. NR_036471.2 RNA Sequence

    Status: VALIDATED

    Description
    This variant (3) uses a different splice site in the 3' end, compared to variant 1. It is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK095651, BU737295, DA762166
  2. NR_036472.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses a different splice site in the 3' end, compared to variant 1. It is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK095651, BU737295
    Related
    ENST00000517311.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    109334347..109345954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    110462889..110474496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)