U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Eny2 ENY2 transcription and export complex 2 subunit [ Mus musculus (house mouse) ]

Gene ID: 223527, updated on 30-Apr-2024

Summary

Official Symbol
Eny2provided by MGI
Official Full Name
ENY2 transcription and export complex 2 subunitprovided by MGI
Primary source
MGI:MGI:1919286
See related
Ensembl:ENSMUSG00000022338 AllianceGenome:MGI:1919286
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DC6; Ey2; 6720481I12; 1810057B09Rik
Summary
Predicted to enable chromatin binding activity and nuclear receptor coactivator activity. Predicted to be involved in several processes, including negative regulation of insulin secretion involved in cellular response to glucose stimulus; poly(A)+ mRNA export from nucleus; and regulation of transcription, DNA-templated. Predicted to act upstream of or within chromatin organization; mRNA transport; and protein transport. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of nucleus. Is expressed in midbrain ventricular layer; neural retinal epithelium; olfactory cortex ventricular layer; and telencephalon ventricular layer. Orthologous to human ENY2 (ENY2 transcription and export complex 2 subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 20.8), CNS E14 (RPKM 20.3) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Eny2 in Genome Data Viewer
Location:
15 B3.2; 15 16.91 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (44291488..44301652)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (44428082..44438256)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38570 Neighboring gene predicted gene, 24903 Neighboring gene predicted gene, 25093 Neighboring gene NudC domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E2440 Neighboring gene predicted gene, 22392 Neighboring gene polycystic kidney and hepatic disease 1-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E10853 Neighboring gene STARR-positive B cell enhancer ABC_E7366 Neighboring gene STARR-seq mESC enhancer starr_38573 Neighboring gene estrogen receptor-binding fragment-associated gene 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of DUBm complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of DUBm complex ISO
Inferred from Sequence Orthology
more info
 
part_of SAGA complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of SAGA complex ISO
Inferred from Sequence Orthology
more info
 
part_of SAGA complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
 
part_of nuclear pore nuclear basket ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of transcription export complex 2 ISO
Inferred from Sequence Orthology
more info
 
part_of transcription factor TFTC complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
transcription and mRNA export factor ENY2
Names
e(y)2 homolog
e(y)2 protein
enhancer of yellow 2 homolog
enhancer of yellow 2 transcription factor homolog
enhancer of yellow eye homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418909.1NP_001405838.1  transcription and mRNA export factor ENY2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC127312
    UniProtKB/TrEMBL
    A0A2I3BRK6
    Related
    ENSMUSP00000154515.2, ENSMUST00000226827.2
  2. NM_175009.4NP_778174.1  transcription and mRNA export factor ENY2 isoform 1

    See identical proteins and their annotated locations for NP_778174.1

    Status: VALIDATED

    Source sequence(s)
    AC127312
    Consensus CDS
    CCDS27456.1
    UniProtKB/Swiss-Prot
    Q9JIX0
    Related
    ENSMUSP00000052905.4, ENSMUST00000060652.5
    Conserved Domains (1) summary
    pfam10163
    Location:1694
    EnY2; Transcription factor e(y)2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    44291488..44301652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)