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GPR108 G protein-coupled receptor 108 [ Homo sapiens (human) ]

Gene ID: 56927, updated on 16-Oct-2021

Summary

Official Symbol
GPR108provided by HGNC
Official Full Name
G protein-coupled receptor 108provided by HGNC
Primary source
HGNC:HGNC:17829
See related
Ensembl:ENSG00000125734 MIM:618491
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LUSTR2
Expression
Ubiquitous expression in thyroid (RPKM 21.4), duodenum (RPKM 17.0) and 25 other tissues See more
Orthologs
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Genomic context

See GPR108 in Genome Data Viewer
Location:
19p13.3
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (6729914..6737580, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6729925..6737633, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene TNF superfamily member 14 Neighboring gene complement C3 Neighboring gene microRNA 6791 Neighboring gene uncharacterized LOC107985302 Neighboring gene thyroid hormone receptor interactor 10 Neighboring gene SH2 domain containing 3A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC14393

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in cis-Golgi network membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein GPR108
Names
lung seven transmembrane receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080452.2NP_001073921.1  protein GPR108 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001073921.1

    Status: VALIDATED

    Source sequence(s)
    AC008760
    Consensus CDS
    CCDS42479.1
    UniProtKB/Swiss-Prot
    Q9NPR9
    Related
    ENSP00000264080.5, ENST00000264080.11
    Conserved Domains (1) summary
    pfam06814
    Location:215503
    Lung_7-TM_R; Lung seven transmembrane receptor
  2. NM_001394714.1NP_001381643.1  protein GPR108 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008760
    Conserved Domains (1) summary
    pfam06814
    Location:1261
    Lung_7-TM_R; Lung seven transmembrane receptor
  3. NM_001394715.1NP_001381644.1  protein GPR108 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008760
    Conserved Domains (1) summary
    pfam06814
    Location:1261
    Lung_7-TM_R; Lung seven transmembrane receptor
  4. NM_001394716.1NP_001381645.1  protein GPR108 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008760
    Conserved Domains (1) summary
    pfam06814
    Location:1261
    Lung_7-TM_R; Lung seven transmembrane receptor
  5. NM_001394717.1NP_001381646.1  protein GPR108 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC008760
    Conserved Domains (1) summary
    cl21735
    Location:216418
    Lung_7-TM_R; Lung seven transmembrane receptor
  6. NM_001394718.1NP_001381647.1  protein GPR108 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC008760
    Conserved Domains (1) summary
    pfam06814
    Location:216503
    Lung_7-TM_R; Lung seven transmembrane receptor
  7. NM_001394719.1NP_001381648.1  protein GPR108 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC008760
    Conserved Domains (1) summary
    pfam06814
    Location:216450
    Lung_7-TM_R; Lung seven transmembrane receptor
  8. NM_001394720.1NP_001381649.1  protein GPR108 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC008760
    Conserved Domains (1) summary
    pfam06814
    Location:216487
    Lung_7-TM_R; Lung seven transmembrane receptor
  9. NM_001394721.1NP_001381650.1  protein GPR108 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC008760
    Conserved Domains (1) summary
    pfam06814
    Location:199486
    Lung_7-TM_R; Lung seven transmembrane receptor
  10. NM_001394722.1NP_001381651.1  protein GPR108 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC008760
    Conserved Domains (1) summary
    pfam06814
    Location:216478
    Lung_7-TM_R; Lung seven transmembrane receptor
  11. NM_001394723.1NP_001381652.1  protein GPR108 isoform 9 precursor

    Status: VALIDATED

    Source sequence(s)
    AC008760
    Conserved Domains (1) summary
    pfam06814
    Location:216450
    Lung_7-TM_R; Lung seven transmembrane receptor
  12. NM_001394724.1NP_001381653.1  protein GPR108 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC008760
    Conserved Domains (1) summary
    cl21735
    Location:1176
    Lung_7-TM_R; Lung seven transmembrane receptor
  13. NM_001394725.1NP_001381654.1  protein GPR108 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC008760
    Conserved Domains (1) summary
    cl21735
    Location:1208
    Lung_7-TM_R; Lung seven transmembrane receptor
  14. NM_001394726.1NP_001381655.1  protein GPR108 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC008760
    Conserved Domains (1) summary
    cl21735
    Location:1208
    Lung_7-TM_R; Lung seven transmembrane receptor
  15. NM_001394727.1NP_001381656.1  protein GPR108 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC008760
    Conserved Domains (1) summary
    cl21735
    Location:1236
    Lung_7-TM_R; Lung seven transmembrane receptor
  16. NM_001394728.1NP_001381657.1  protein GPR108 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC008760
    Conserved Domains (1) summary
    cl21735
    Location:1208
    Lung_7-TM_R; Lung seven transmembrane receptor
  17. NM_020171.2NP_064556.1  protein GPR108 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008760
    Consensus CDS
    CCDS45940.1
    Related
    ENSP00000401284.2, ENST00000430424.8
    Conserved Domains (1) summary
    pfam06814
    Location:1261
    Lung_7-TM_R; Lung seven transmembrane receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    6729914..6737580 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451618.1XP_024307386.1  protein GPR108 isoform X4

    Conserved Domains (1) summary
    pfam06814
    Location:53341
    Lung_7-TM_R; Lung seven transmembrane receptor
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