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PAK6 p21 (RAC1) activated kinase 6 [ Homo sapiens (human) ]

Gene ID: 56924, updated on 2-Mar-2021

Summary

Official Symbol
PAK6provided by HGNC
Official Full Name
p21 (RAC1) activated kinase 6provided by HGNC
Primary source
HGNC:HGNC:16061
See related
Ensembl:ENSG00000137843 MIM:608110
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAK5
Summary
This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Expression
Broad expression in testis (RPKM 8.7), brain (RPKM 8.5) and 14 other tissues See more
Orthologs
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Genomic context

See PAK6 in Genome Data Viewer
Location:
15q15.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (40239063..40277487)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (40531264..40569688)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene MT-ND4 pseudogene 37 Neighboring gene uncharacterized LOC107984763 Neighboring gene BUB1 mitotic checkpoint serine/threonine kinase B Neighboring gene BUB1B-PAK6 readthrough Neighboring gene PAK6 antisense RNA 1 Neighboring gene ankyrin repeat domain 63 Neighboring gene phospholipase C beta 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough BUB1B-PAK6

Readthrough gene: BUB1B-PAK6, Included gene: BUB1B

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
learning IEA
Inferred from Electronic Annotation
more info
 
locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
memory IEA
Inferred from Electronic Annotation
more info
 
neuron projection arborization IEA
Inferred from Electronic Annotation
more info
 
neuron projection extension IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
stress-activated protein kinase signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell junction IDA
Inferred from Direct Assay
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fibrillar center IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase PAK 6
Names
p21 protein (Cdc42/Rac)-activated kinase 6
p21(CDKN1A)-activated kinase 6
NP_001263646.1
NP_001263647.1
NP_064553.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033169.1 RefSeqGene

    Range
    26636..65060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276717.1NP_001263646.1  serine/threonine-protein kinase PAK 6 isoform 1

    See identical proteins and their annotated locations for NP_001263646.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and the 3' UTR, compared to variant 1. Variants 1 and 4 encode the same isoform (1).
    Source sequence(s)
    BC035596, DA191028
    Consensus CDS
    CCDS10054.1
    UniProtKB/Swiss-Prot
    Q9NQU5
    UniProtKB/TrEMBL
    A0A024R9Q4
    Related
    ENSP00000439597.2, ENST00000542403.3
    Conserved Domains (2) summary
    cd06659
    Location:385681
    STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
    pfam00786
    Location:1167
    PBD; P21-Rho-binding domain
  2. NM_001276718.2NP_001263647.1  serine/threonine-protein kinase PAK 6 isoform 2

    See identical proteins and their annotated locations for NP_001263647.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC020658, AK026592, AK131522, BC035596
    Consensus CDS
    CCDS61590.1
    UniProtKB/Swiss-Prot
    Q9NQU5
    Related
    ENSP00000409465.2, ENST00000455577.6
    Conserved Domains (3) summary
    smart00220
    Location:412613
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam00786
    Location:1163
    PBD; P21-Rho-binding domain
    cl21453
    Location:385636
    PKc_like; Protein Kinases, catalytic domain
  3. NM_020168.6NP_064553.1  serine/threonine-protein kinase PAK 6 isoform 1

    See identical proteins and their annotated locations for NP_064553.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 4 encode the same isoform (1).
    Source sequence(s)
    AC020658
    Consensus CDS
    CCDS10054.1
    UniProtKB/Swiss-Prot
    Q9NQU5
    UniProtKB/TrEMBL
    A0A024R9Q4
    Related
    ENSP00000260404.4, ENST00000260404.8
    Conserved Domains (2) summary
    cd06659
    Location:385681
    STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
    pfam00786
    Location:1167
    PBD; P21-Rho-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    40239063..40277487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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