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BUB1B-PAK6 BUB1B-PAK6 readthrough [ Homo sapiens (human) ]

Gene ID: 106821730, updated on 23-Nov-2021

Summary

Official Symbol
BUB1B-PAK6provided by HGNC
Official Full Name
BUB1B-PAK6 readthroughprovided by HGNC
Primary source
HGNC:HGNC:52276
See related
Ensembl:ENSG00000137843
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAK5; PAK6; PAK-5; PAK-6
Summary
This gene represents readthrough transcription between the genes BUB1B (mitotic checkpoint serine/threonine-protein kinase BUB1 beta) and PAK6 (serine/threonine-protein kinase PAK 6). The protein encoded by the readthrough transcripts is the same as the product of the downstream gene (PAK6). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Expression
Broad expression in testis (RPKM 10.8), skin (RPKM 9.9) and 18 other tissues See more
Orthologs
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Genomic context

See BUB1B-PAK6 in Genome Data Viewer
Location:
15q15.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (40217428..40277487)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (40509629..40569688)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene MT-ND5 pseudogene 37 Neighboring gene MT-ND4 pseudogene 37 Neighboring gene uncharacterized LOC107984763 Neighboring gene BUB1 mitotic checkpoint serine/threonine kinase B Neighboring gene p21 (RAC1) activated kinase 6 Neighboring gene PAK6 antisense RNA 1 Neighboring gene ankyrin repeat domain 63 Neighboring gene phospholipase C beta 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

General gene information

Readthrough BUB1B-PAK6

Included genes: BUB1B, PAK6

Homology

Clone Names

  • FLJ75021, FLJ79462, FLJ79466

General protein information

Preferred Names
serine/threonine-protein kinase PAK 6
Names
p21-activated kinase 6
NP_001122100.1
NP_001122101.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128628.3NP_001122100.1  serine/threonine-protein kinase PAK 6

    See identical proteins and their annotated locations for NP_001122100.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK026592, AK131522, AK290227, BC035596, DA414215
    UniProtKB/Swiss-Prot
    Q9NQU5
    UniProtKB/TrEMBL
    A0A024R9Q4
    Related
    ENSP00000406873.1, ENST00000441369.6
    Conserved Domains (2) summary
    cd06659
    Location:385681
    STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
    pfam00786
    Location:1167
    PBD; P21-Rho-binding domain
  2. NM_001128629.3NP_001122101.1  serine/threonine-protein kinase PAK 6

    See identical proteins and their annotated locations for NP_001122101.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK026592, AK131522, AK315817, BC035596
    UniProtKB/Swiss-Prot
    Q9NQU5
    UniProtKB/TrEMBL
    A0A024R9Q4
    Related
    ENSP00000401153.3, ENST00000453867.7
    Conserved Domains (2) summary
    cd06659
    Location:385681
    STKc_PAK6; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6
    pfam00786
    Location:1167
    PBD; P21-Rho-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    40217428..40277487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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