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PSMB4 proteasome 20S subunit beta 4 [ Homo sapiens (human) ]

Gene ID: 5692, updated on 6-May-2021

Summary

Official Symbol
PSMB4provided by HGNC
Official Full Name
proteasome 20S subunit beta 4provided by HGNC
Primary source
HGNC:HGNC:9541
See related
Ensembl:ENSG00000159377 MIM:602177
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HN3; HsN3; PRAAS3; PROS26; PROS-26
Summary
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in placenta (RPKM 102.8), lymph node (RPKM 94.8) and 25 other tissues See more
Orthologs
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Genomic context

See PSMB4 in Genome Data Viewer
Location:
1q21.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (151399573..151401937)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151372049..151374413)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RFX5 antisense RNA 1 Neighboring gene regulatory factor X5 Neighboring gene selenium binding protein 1 Neighboring gene pogo transposable element derived with ZNF domain Neighboring gene RNY4 pseudogene 25 Neighboring gene cingulin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
GeneReviews: Not available
Proteasome-associated autoinflammatory syndrome 3
MedGen: C4747850 OMIM: 617591 GeneReviews: Not available
Compare labs

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef was found to markedly downregulate intracellular levels of both a co-expressed HsN3 and the endogenous simian homologue, suggesting Nef may alter proteasome function in infected cells PubMed
nef Amino acids 34-143 of HIV-1 Nef mediate its binding to amino acids 73-249 of the HsN3 proteasomal subunit PubMed
Tat tat HIV-1 Tat slightly enhances the activity of the purified 26 S proteasome PubMed
tat Amino acids Lys51, Arg52, and Asp67 of HIV-1 Tat represent the proteasome binding site of Tat, and Tat amino acids 37-72 are necessary for proteasomal interaction and suppression of 11 S regulator-mediated antigen presentation PubMed
tat HIV-1 Tat inhibits the peptidase activity of the 20 S proteasome and interferes with the formation of the 20 S proteasome-11 S regulator complex PubMed
tat HIV-1 Tat binds to the alpha2, alpha4, alpha6, alpha7, beta1, beta2, beta3, beta5, beta6, beta7, LMP7/beta5i, and MECL1/beta2i subunits of the proteasome 20 S core structure and can inhibit cellular proteasome function PubMed
Vif vif HIV-1 Vif binds to the cellular cytidine deaminase APOBEC3G and targets it for degradation through an interaction with the proteasome, thereby inhibiting APOBEC3G mediated restriction of HIV-1 replication PubMed
integrase gag-pol Proteasomal degradation of HIV-1 integrase in mammalian cells occurs by the N-end rule pathway PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lipopolysaccharide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables threonine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in MAPK cascade TAS
Traceable Author Statement
more info
 
involved_in NIK/NF-kappaB signaling TAS
Traceable Author Statement
more info
 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 
involved_in T cell receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in Wnt signaling pathway, planar cell polarity pathway TAS
Traceable Author Statement
more info
 
involved_in anaphase-promoting complex-dependent catabolic process TAS
Traceable Author Statement
more info
 
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
Traceable Author Statement
more info
 
involved_in interleukin-1-mediated signaling pathway TAS
Traceable Author Statement
more info
 
involved_in negative regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
involved_in negative regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
 
involved_in negative regulation of inflammatory response to antigenic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
 
involved_in post-translational protein modification TAS
Traceable Author Statement
more info
 
involved_in pre-replicative complex assembly TAS
Traceable Author Statement
more info
 
involved_in proteasomal ubiquitin-independent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 
involved_in protein deubiquitination TAS
Traceable Author Statement
more info
 
involved_in protein polyubiquitination TAS
Traceable Author Statement
more info
 
involved_in regulation of cellular amino acid metabolic process TAS
Traceable Author Statement
more info
 
involved_in regulation of hematopoietic stem cell differentiation TAS
Traceable Author Statement
more info
 
involved_in regulation of mRNA stability TAS
Traceable Author Statement
more info
 
involved_in regulation of mitotic cell cycle phase transition TAS
Traceable Author Statement
more info
 
involved_in regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
Traceable Author Statement
more info
 
involved_in stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in transmembrane transport TAS
Traceable Author Statement
more info
 
involved_in tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
part_of proteasome complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome core complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proteasome core complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of proteasome core complex, beta-subunit complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
proteasome subunit beta type-4
Names
26 kDa prosomal protein
hsBPROS26
macropain beta chain
multicatalytic endopeptidase complex beta chain
proteasome (prosome, macropain) subunit, beta type, 4
proteasome beta chain
proteasome chain 3
proteasome subunit HsN3
proteasome subunit beta 4
proteasome subunit beta7
proteasome subunit, beta type, 4
testis tissue sperm-binding protein Li 79P
NP_002787.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002796.3NP_002787.2  proteasome subunit beta type-4

    See identical proteins and their annotated locations for NP_002787.2

    Status: REVIEWED

    Source sequence(s)
    AL589764
    Consensus CDS
    CCDS996.1
    UniProtKB/Swiss-Prot
    P28070
    UniProtKB/TrEMBL
    A0A140VK46
    Related
    ENSP00000290541.6, ENST00000290541.7
    Conserved Domains (1) summary
    cd03760
    Location:52247
    proteasome_beta_type_4; proteasome beta type-4 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    151399573..151401937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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