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Psmb4 proteasome (prosome, macropain) subunit, beta type 4 [ Mus musculus (house mouse) ]

Gene ID: 19172, updated on 5-Feb-2023

Summary

Official Symbol
Psmb4provided by MGI
Official Full Name
proteasome (prosome, macropain) subunit, beta type 4provided by MGI
Primary source
MGI:MGI:1098257
See related
Ensembl:ENSMUSG00000005779 AllianceGenome:MGI:1098257
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pros-27
Summary
Enables lipopolysaccharide binding activity. Involved in negative regulation of inflammatory response to antigenic stimulus. Part of proteasome core complex. Is expressed in cerebral cortex and embryo. Orthologous to human PSMB4 (proteasome 20S subunit beta 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 131.5), large intestine adult (RPKM 127.3) and 28 other tissues See more
Orthologs
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Genomic context

See Psmb4 in Genome Data Viewer
Location:
3 F2.1; 3 40.74 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (94791635..94794269, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (94884324..94886958, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40094 Neighboring gene pogo transposable element with ZNF domain Neighboring gene special AT-rich sequence binding protein 1 pseudogene Neighboring gene predicted gene, 36237 Neighboring gene predicted gene, 26279 Neighboring gene selenium binding protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome core complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex, beta-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
proteasome subunit beta type-4
Names
low molecular mass protein 3
macropain beta chain
multicatalytic endopeptidase complex beta chain
proteasome beta chain
proteasome chain 3
NP_032971.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008945.3NP_032971.2  proteasome subunit beta type-4

    See identical proteins and their annotated locations for NP_032971.2

    Status: VALIDATED

    Source sequence(s)
    AK077448, CB058553
    Consensus CDS
    CCDS17597.1
    UniProtKB/Swiss-Prot
    P99026, Q91VV7
    Related
    ENSMUSP00000005923.7, ENSMUST00000005923.7
    Conserved Domains (2) summary
    COG0638
    Location:45241
    PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
    cd03760
    Location:52247
    proteasome_beta_type_4; proteasome beta type-4 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    94791635..94794269 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)