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Psmb4 proteasome (prosome, macropain) subunit, beta type 4 [ Mus musculus (house mouse) ]

Gene ID: 19172, updated on 5-Aug-2018

Summary

Official Symbol
Psmb4provided by MGI
Official Full Name
proteasome (prosome, macropain) subunit, beta type 4provided by MGI
Primary source
MGI:MGI:1098257
See related
Ensembl:ENSMUSG00000005779 Vega:OTTMUSG00000019673
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pros-27
Expression
Ubiquitous expression in placenta adult (RPKM 131.5), large intestine adult (RPKM 127.3) and 28 other tissues See more
Orthologs

Genomic context

See Psmb4 in Genome Data Viewer
Location:
3 F2.1; 3 40.74 cM
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (94884324..94886958, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (94688246..94690880, complement)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40094 Neighboring gene pogo transposable element with ZNF domain Neighboring gene special AT-rich sequence binding protein 1 pseudogene Neighboring gene predicted gene, 36237 Neighboring gene selenium binding protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
threonine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of inflammatory response to antigenic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteasomal protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasomal ubiquitin-independent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
proteolysis involved in cellular protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
proteasome complex ISO
Inferred from Sequence Orthology
more info
 
proteasome core complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome core complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proteasome subunit beta type-4
Names
low molecular mass protein 3
macropain beta chain
multicatalytic endopeptidase complex beta chain
proteasome beta chain
proteasome chain 3
NP_032971.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008945.3NP_032971.2  proteasome subunit beta type-4 precursor

    See identical proteins and their annotated locations for NP_032971.2

    Status: VALIDATED

    Source sequence(s)
    AK077448, CB058553
    Consensus CDS
    CCDS17597.1
    UniProtKB/Swiss-Prot
    P99026
    Related
    ENSMUSP00000005923.6, OTTMUSP00000021272, ENSMUST00000005923.6, OTTMUST00000047083
    Conserved Domains (2) summary
    COG0638
    Location:45241
    PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
    cd03760
    Location:52247
    proteasome_beta_type_4; proteasome beta type-4 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

    Range
    94884324..94886958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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