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DPYSL5 dihydropyrimidinase like 5 [ Homo sapiens (human) ]

Gene ID: 56896, updated on 5-Apr-2020

Summary

Official Symbol
DPYSL5provided by HGNC
Official Full Name
dihydropyrimidinase like 5provided by HGNC
Primary source
HGNC:HGNC:20637
See related
Ensembl:ENSG00000157851 MIM:608383
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CV2; CRAM; CRMP5; Ulip6; CRMP-5
Summary
This gene encodes a member of the CRMP (collapsing response mediator protein) family thought to be involved in neural development. Antibodies to the encoded protein were found in some patients with neurologic symptoms who had paraneoplastic syndrome. A pseudogene of this gene is found on chromosome 11. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]
Expression
Biased expression in brain (RPKM 10.7), testis (RPKM 2.0) and 1 other tissue See more
Orthologs

Genomic context

See DPYSL5 in Genome Data Viewer
Location:
2p23.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (26848102..26950351)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27070969..27173219)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene centromere protein A Neighboring gene CDKN2A interacting protein N-terminal like pseudogene 2 Neighboring gene microtubule associated protein RP/EB family member 3 Neighboring gene MAPRE3 antisense RNA 1 Neighboring gene transmembrane protein 214

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of dihydropyrimidinase-like 5 (DPYSL5) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45383

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT dihydropyrimidinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
axon guidance IEA
Inferred from Electronic Annotation
more info
 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
NOT pyrimidine nucleobase catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dihydropyrimidinase-related protein 5
Names
CRMP3-associated molecule
DRP-5
ULIP-6
UNC33-like phosphoprotein 6
collapsin response mediator protein-5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253723.1NP_001240652.1  dihydropyrimidinase-related protein 5

    See identical proteins and their annotated locations for NP_001240652.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC013472, AW139156, BC002874
    Consensus CDS
    CCDS1730.1
    UniProtKB/Swiss-Prot
    Q9BPU6
    Related
    ENSP00000385549.1, ENST00000401478.5
    Conserved Domains (1) summary
    cd01314
    Location:10459
    D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
  2. NM_001253724.1NP_001240653.1  dihydropyrimidinase-related protein 5

    See identical proteins and their annotated locations for NP_001240653.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC013472, AL713706, AW139156, DA410946
    Consensus CDS
    CCDS1730.1
    UniProtKB/Swiss-Prot
    Q9BPU6
    Related
    ENSP00000481305.1, ENST00000614712.4
    Conserved Domains (1) summary
    cd01314
    Location:10459
    D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
  3. NM_020134.4NP_064519.2  dihydropyrimidinase-related protein 5

    See identical proteins and their annotated locations for NP_064519.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC013472, AF264015, AW139156
    Consensus CDS
    CCDS1730.1
    UniProtKB/Swiss-Prot
    Q9BPU6
    Related
    ENSP00000288699.6, ENST00000288699.11
    Conserved Domains (1) summary
    cd01314
    Location:10459
    D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    26848102..26950351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453007.1XP_024308775.1  dihydropyrimidinase-related protein 5 isoform X1

    Conserved Domains (1) summary
    cd01314
    Location:10459
    D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...

RNA

  1. XR_001738852.2 RNA Sequence

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