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ablim2 actin binding LIM protein family, member 2 [ Danio rerio (zebrafish) ]

Gene ID: 568454, updated on 17-Sep-2024

Summary

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Official Symbol
ablim2provided by ZNC
Official Full Name
actin binding LIM protein family, member 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-100316-5
See related
Ensembl:ENSDARG00000055223 AllianceGenome:ZFIN:ZDB-GENE-100316-5
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in lamellipodium assembly. Predicted to act upstream of or within actin cytoskeleton organization and transcription, DNA-templated. Predicted to be located in cytoplasm. Predicted to be active in actin cytoskeleton. Orthologous to human ABLIM2 (actin binding LIM protein family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 12
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (22680183..22822950)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (22558887..22696782)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103911920 Neighboring gene cell division cycle associated 9 Neighboring gene uncharacterized LOC101883633 Neighboring gene actin filament associated protein 1 Neighboring gene RAB18A, member RAS oncogene family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolution and expression of the phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity. Lagman D, et al. BMC Evol Biol, 2016 Jun 13. PMID 27296292, Free PMC Article
  2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
actin-binding LIM protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    22680183..22822950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068224766.1 → XP_068080867.1  actin-binding LIM protein 2 isoform X3

    Related
    ENSDARP00000127095.1, ENSDART00000152879.3

  2. XM_009306734.4 → XP_009305009.1  actin-binding LIM protein 2 isoform X12

    UniProtKB/TrEMBL
    A0A8M3B4Q6
    Conserved Domains (6) summary
    smart00153
    Location:565 → 600
    VHP; Villin headpiece domain
    cd09327
    Location:30 → 81
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:86 → 141
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:158 → 209
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:217 → 272
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:282 → 564
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  3. XM_068224769.1 → XP_068080870.1  actin-binding LIM protein 2 isoform X5

  4. XM_068224771.1 → XP_068080872.1  actin-binding LIM protein 2 isoform X7

  5. XM_068224767.1 → XP_068080868.1  actin-binding LIM protein 2 isoform X4

  6. XM_068224765.1 → XP_068080866.1  actin-binding LIM protein 2 isoform X2

  7. XM_068224774.1 → XP_068080875.1  actin-binding LIM protein 2 isoform X10

  8. XM_068224773.1 → XP_068080874.1  actin-binding LIM protein 2 isoform X9

  9. XM_068224772.1 → XP_068080873.1  actin-binding LIM protein 2 isoform X8

  10. XM_068224770.1 → XP_068080871.1  actin-binding LIM protein 2 isoform X6

  11. XM_068224768.1 → XP_068080869.1  actin-binding LIM protein 2 isoform X1

  12. XM_068224775.1 → XP_068080876.1  actin-binding LIM protein 2 isoform X11

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394840.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    85889..206387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068218674.1 → XP_068074775.1  actin-binding LIM protein 2 isoform X13

  2. XM_021472538.2 → XP_021328213.1  actin-binding LIM protein 2 isoform X18

    UniProtKB/TrEMBL
    A0A8M9PMD1
    Conserved Domains (6) summary
    smart00153
    Location:638 → 673
    VHP; Villin headpiece domain
    cd09327
    Location:30 → 81
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:86 → 141
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:158 → 209
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:217 → 272
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:282 → 637
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  3. XM_068218675.1 → XP_068074776.1  actin-binding LIM protein 2 isoform X14

  4. XM_068218676.1 → XP_068074777.1  actin-binding LIM protein 2 isoform X15

  5. XM_068218678.1 → XP_068074779.1  actin-binding LIM protein 2 isoform X17

  6. XM_068218673.1 → XP_068074774.1  actin-binding LIM protein 2 isoform X1

  7. XM_068218677.1 → XP_068074778.1  actin-binding LIM protein 2 isoform X16

Nucleotide Protein Strain
Heading Accession and Version

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Other Literature Sources
Molecular Biology Databases
Research Materials