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PRSS3 serine protease 3 [ Homo sapiens (human) ]

Gene ID: 5646, updated on 9-Feb-2020

Summary

Official Symbol
PRSS3provided by HGNC
Official Full Name
serine protease 3provided by HGNC
Primary source
HGNC:HGNC:9486
See related
Ensembl:ENSG00000010438 MIM:613578
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
T9; MTG; TRY3; TRY4; PRSS4
Summary
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]
Expression
Restricted expression toward pancreas (RPKM 3091.3) See more
Orthologs

Genomic context

See PRSS3 in Genome Data Viewer
Location:
9p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (33750466..33799231)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (33750464..33799229)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene T cell receptor beta variable 26/OR9-2 (pseudogene) Neighboring gene long intergenic non-protein coding RNA 1251 Neighboring gene T cell receptor beta variable 29/OR9-2 (non-functional) Neighboring gene ubiquitin conjugating enzyme E2 R2 Neighboring gene RNA, U4atac small nuclear 11, pseudogene Neighboring gene small nucleolar RNA, C/D box 121B Neighboring gene ubiquitin associated protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
antimicrobial humoral response TAS
Traceable Author Statement
more info
 
cobalamin metabolic process TAS
Traceable Author Statement
more info
 
digestion TAS
Traceable Author Statement
more info
PubMed 
endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis NAS
Non-traceable Author Statement
more info
PubMed 
zymogen activation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
tertiary granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
trypsin-3
Names
brain trypsinogen
mesotrypsin
mesotrypsinogen
pancreatic trypsinogen III
protease, serine 3
protease, serine, 4 (trypsin 4, brain)
trypsin III
trypsin IV
trypsinogen 4
trypsinogen 5
trypsinogen IV
NP_001184026.2
NP_001184027.1
NP_002762.2
NP_031369.2
XP_011516267.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_001337.2 

    Range
    144006..192771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
  2. NG_029635.1 RefSeqGene

    Range
    5001..53766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001197097.2NP_001184026.2  trypsin-3 isoform 3 preproprotein

    See identical proteins and their annotated locations for NP_001184026.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB298285, AB298286, AY052783
    Consensus CDS
    CCDS56571.1
    UniProtKB/Swiss-Prot
    P35030
    UniProtKB/TrEMBL
    Q7Z5F4
    Related
    ENSP00000340889.4, ENST00000342836.8
    Conserved Domains (2) summary
    smart00020
    Location:37253
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:38256
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_001197098.1NP_001184027.1  trypsin-3 isoform 4 preproprotein

    See identical proteins and their annotated locations for NP_001184027.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains a different in-frame first exon and uses an alternate start codon, compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AB298286
    Consensus CDS
    CCDS56570.1
    UniProtKB/Swiss-Prot
    P35030
    Related
    ENSP00000401828.3, ENST00000429677.7
    Conserved Domains (2) summary
    smart00020
    Location:16232
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:17235
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. NM_002771.3NP_002762.2  trypsin-3 isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_002762.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AB298285, BC069494
    Consensus CDS
    CCDS6545.1
    UniProtKB/Swiss-Prot
    P35030
    Related
    ENSP00000368715.3, ENST00000379405.3
    Conserved Domains (2) summary
    smart00020
    Location:23239
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:24242
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  4. NM_007343.3NP_031369.2  trypsin-3 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_031369.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB298285
    Consensus CDS
    CCDS47958.1
    UniProtKB/Swiss-Prot
    P35030
    Related
    ENSP00000354280.5, ENST00000361005.9
    Conserved Domains (2) summary
    smart00020
    Location:80296
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:81299
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    33750466..33799231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517965.1XP_011516267.1  trypsin-3 isoform X1

    Conserved Domains (2) summary
    smart00020
    Location:109325
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:110328
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
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