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Nat Genet. 2008 Sep;40(9):1056-8. doi: 10.1038/ng.209.

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.

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1
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

Abstract

To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.

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PMID:
18711365
PMCID:
PMC2703780
DOI:
10.1038/ng.209
[Indexed for MEDLINE]
Free PMC Article

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