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PRSS2 serine protease 2 [ Homo sapiens (human) ]

Gene ID: 5645, updated on 10-Jul-2020

Summary

Official Symbol
PRSS2provided by HGNC
Official Full Name
serine protease 2provided by HGNC
Primary source
HGNC:HGNC:9483
See related
Ensembl:ENSG00000275896 MIM:601564
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRY2; TRY8; TRYP2
Summary
This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]
Orthologs

Genomic context

See PRSS2 in Genome Data Viewer
Location:
7q34
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (142770943..142774564)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 (PATCHES) NW_003571040.1 (974016..977604)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene T cell receptor beta locus Neighboring gene T cell receptor beta variable 29-1 Neighboring gene serine protease 1 Neighboring gene PRSS3 pseudogene 1 Neighboring gene WBP1L pseudogene 1 Neighboring gene T cell receptor beta diversity 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Hereditary pancreatitis Compare labs

NHGRI GWAS Catalog

Description
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Genes, including GABRP, ADF, HINT, PRSS2, SDCBP, PTK9, PPP2R5B, ITGA3, PRKCBP1, HMOX2, HAT1, PPP1cB, and ICAM-1, are upregulated after treatment of human astrocytes with HIV-1 gp120 PubMed
env Cleavage of HIV-1 gp120 with trypsin at residue 432 destroys CD4 binding PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111183, MGC120174, MGC120175

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
antimicrobial humoral response TAS
Traceable Author Statement
more info
 
collagen catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
collagen catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
collagen catabolic process TAS
Traceable Author Statement
more info
 
digestion IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix disassembly TAS
Traceable Author Statement
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of cell adhesion TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cell growth TAS
Traceable Author Statement
more info
PubMed 
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
azurophil granule lumen TAS
Traceable Author Statement
more info
 
extracellular matrix TAS
Traceable Author Statement
more info
PubMed 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
trypsin-2
Names
anionic trypsinogen
protease serine 2 preproprotein
protease, serine 2
protease, serine, 2 (trypsin 2)
trypsin II
trypsinogen 2
NP_001290343.1
NP_002761.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_001333.2 

    Range
    624987..628610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
  2. NG_008322.2 RefSeqGene

    Range
    5028..8618
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001303414.1NP_001290343.1  trypsin-2 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001290343.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC245427, BC005814, BC030260, BQ786948, CA867206, DQ846873
    Consensus CDS
    CCDS83235.1
    UniProtKB/TrEMBL
    A6XMV9, Q6PK75
    Related
    ENSP00000488437.1, ENST00000633969.1
    Conserved Domains (2) summary
    smart00020
    Location:23253
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:24256
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_002770.4NP_002761.1  trypsin-2 isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_002761.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC245427, BC005814, BC030260, CA867206
    Consensus CDS
    CCDS83236.1
    UniProtKB/Swiss-Prot
    P07478
    UniProtKB/TrEMBL
    Q5NV56, Q6PK75
    Related
    ENSP00000488338.1, ENST00000539842.5
    Conserved Domains (2) summary
    smart00020
    Location:23239
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:24242
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RNA

  1. NR_130149.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal exon and uses an alternate splice acceptor site at an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC245427, BC005814, BC030260, CA867206, CA951033
    Related
    ENST00000618750.2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    142770943..142774564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187562.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    793916..797537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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