grk1a G protein-coupled receptor kinase 1 a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: grk1aprovided by ZNC
Official Full Name: G protein-coupled receptor kinase 1 aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050823-1
See related: Ensembl:ENSDARG00000058803 AllianceGenome:ZFIN:ZDB-GENE-050823-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: grk1
Summary: Enables rhodopsin kinase activity. Predicted to be involved in protein phosphorylation and regulation of signal transduction. Predicted to act upstream of or within several processes, including phosphorylation; regulation of rhodopsin mediated signaling pathway; and visual perception. Predicted to be active in cytoplasm. Is expressed in epiphysis; eye; retinal photoreceptor layer; and retinal rod cell. Human ortholog(s) of this gene implicated in Oguchi disease-2 and night blindness. Orthologous to human GRK1 (G protein-coupled receptor kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (245137..256233)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (249958..261054)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Grk7 but not Grk1 undergoes cAMP-dependent phosphorylation in zebrafish cone photoreceptors and mediates cone photoresponse recovery to elevated cAMP.
Title: Grk7 but not Grk1 undergoes cAMP-dependent phosphorylation in zebrafish cone photoreceptors and mediates cone photoresponse recovery to elevated cAMP.
For the first time, we demonstrate that Grk1b and Grk7a both contribute to visual function in larval zebrafish cones. Since the difference between wildtype and each knockout fish is modest, it appears that either GRK is sufficient for adequate cone visual function.
Title: Grk1b and Grk7a Both Contribute to the Recovery of the Isolated Cone Photoresponse in Larval Zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables rhodopsin kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables rhodopsin kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables rhodopsin kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of opsin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rhodopsin kinase GRK1

Names: G-protein-coupled receptor kinase 1a

NP_001029353.2

EC 2.7.11.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034181.2 → NP_001029353.2 rhodopsin kinase GRK1

See identical proteins and their annotated locations for NP_001029353.2

Status: PROVISIONAL

Source sequence(s)

AB212993

UniProtKB/TrEMBL

B3DJQ8, Q1XHM0

Related

ENSDARP00000076182.5, ENSDART00000081743.6

Conserved Domains (3) summary

smart00220
Location:195 → 456

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05608
Location:189 → 476

STKc_GRK1; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 1

cl02565
Location:43 → 180

RGS; Regulator of G protein signaling (RGS) domain superfamily