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GRK1 G protein-coupled receptor kinase 1 [ Homo sapiens (human) ]

Gene ID: 6011, updated on 23-Nov-2023

Summary

Official Symbol
GRK1provided by HGNC
Official Full Name
G protein-coupled receptor kinase 1provided by HGNC
Primary source
HGNC:HGNC:10013
See related
Ensembl:ENSG00000185974 MIM:180381; AllianceGenome:HGNC:10013
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RK; RHOK; GPRK1
Summary
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008]
Annotation information
Note: This gene aligns across a gap in the GRCh38 reference genome assembly, and therefore, the 5' end of this gene was annotated on NT_027140.7 and the 3' end was annotated on NT_024498.13 in NCBI s Homo sapiens Annotation Release 106. [17 Jun 2014]
Annotation category: suggests misassembly
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See GRK1 in Genome Data Viewer
Location:
13q34
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (113648199..113737736)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (112903498..112947029)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (114321534..114440709)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene defective in cullin neddylation 1 domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5548 Neighboring gene transmembrane and coiled-coil domains 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:114192765-114192953 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:114195260-114196459 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114200259-114201002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114206049-114206550 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114236917-114237890 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114237891-114238862 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5549 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5550 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114240840-114241440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114251630-114252130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114267642-114268206 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114268207-114268770 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114269335-114269898 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114269899-114270462 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114271027-114271590 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114271591-114272153 Neighboring gene uncharacterized LOC124903219 Neighboring gene transcription factor Dp-1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:114279174-114280373 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114305936-114306560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114306561-114307185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114311832-114312332 Neighboring gene ATPase H+/K+ transporting subunit beta Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:114426222-114426826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114426827-114427432 Neighboring gene basic salivary proline-rich protein 4-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114446225-114446726 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:114456174-114456392 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114461359-114461860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114462417-114462918 Neighboring gene long intergenic non-protein coding RNA 552 Neighboring gene transmembrane protein 255B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114491163-114491692 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114491693-114492221 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114504133-114505007 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114506713-114507271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8040 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8041 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8042 Neighboring gene GAS6 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables rhodopsin kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables rhodopsin kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables rhodopsin kinase activity TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in photoreceptor disc membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
rhodopsin kinase GRK1
NP_002920.1
XP_047286449.1
XP_054230761.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002929.3NP_002920.1  rhodopsin kinase GRK1

    See identical proteins and their annotated locations for NP_002920.1

    Status: REVIEWED

    Source sequence(s)
    AC187648, BX537316
    Consensus CDS
    CCDS81785.1
    UniProtKB/Swiss-Prot
    Q15835, Q53X14
    UniProtKB/TrEMBL
    B9EIS4
    Related
    ENSP00000334876.5, ENST00000335678.7
    Conserved Domains (2) summary
    cd05608
    Location:188475
    STKc_GRK1; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 1
    cl02565
    Location:42179
    RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    113648199..113737736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430493.1XP_047286449.1  rhodopsin kinase GRK1 isoform X1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160011.1 Reference GRCh38.p14 PATCHES

    Range
    18042..39335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187596.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    4331..11261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    112903498..112947029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374786.1XP_054230761.1  rhodopsin kinase GRK1 isoform X1