rcor3 REST corepressor 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rcor3provided by ZNC
Official Full Name: REST corepressor 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-050208-371
See related: Ensembl:ENSDARG00000004502 AllianceGenome:ZFIN:ZDB-GENE-050208-371
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch211-284e20.6
Summary: Predicted to enable transcription corepressor activity. Predicted to be involved in histone deacetylation; negative regulation of transcription, DNA-templated; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of histone deacetylase complex and transcription regulator complex. Orthologous to human RCOR3 (REST corepressor 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (38275990..38299011)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (38322851..38341305)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of histone deacetylase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: REST corepressor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045029.1 → NP_001038494.1 REST corepressor 3

Status: PROVISIONAL

Source sequence(s)

AL954145

UniProtKB/TrEMBL

A0A8M1N9W5, Q1MT18

Related

ENSDARP00000115189.2, ENSDART00000143792.3

Conserved Domains (5) summary

smart00717
Location:335 → 380

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:335 → 378

Myb_DNA-binding; Myb-like DNA-binding domain

pfam01448
Location:45 → 96

ELM2; ELM2 domain

cl21498
Location:132 → 176

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

cl22974
Location:467 → 547

HpaP; Type III secretion protein (HpaP)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007133.7 Reference GRCz11 Primary Assembly

Range

38275990..38299011

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005161857.5 → XP_005161914.1 REST corepressor 3 isoform X1

UniProtKB/TrEMBL

A0A8M2B8S4

Conserved Domains (5) summary

smart00717
Location:333 → 378

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:333 → 376

Myb_DNA-binding; Myb-like DNA-binding domain

pfam01448
Location:45 → 96

ELM2; ELM2 domain

cl21498
Location:132 → 176

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

cl22974
Location:465 → 545

HpaP; Type III secretion protein (HpaP)