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RCOR3 REST corepressor 3 [ Homo sapiens (human) ]

Gene ID: 55758, updated on 18-Aug-2020

Summary

Official Symbol
RCOR3provided by HGNC
Official Full Name
REST corepressor 3provided by HGNC
Primary source
HGNC:HGNC:25594
See related
Ensembl:ENSG00000117625
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 13.7), thyroid (RPKM 11.6) and 25 other tissues See more
Orthologs

Genomic context

See RCOR3 in Genome Data Viewer
Location:
1q32.2-q32.3
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (211259366..211316385)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (211432708..211489727)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PRELID1 pseudogene 5 Neighboring gene uncharacterized LOC105372902 Neighboring gene TNF receptor associated factor 5 Neighboring gene uncharacterized LOC107985258

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10876, FLJ16298

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
histone deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
histone deacetylase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136223.3NP_001129695.1  REST corepressor 3 isoform a

    See identical proteins and their annotated locations for NP_001129695.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AK302664, AL590101, BU689437, HY024910
    Consensus CDS
    CCDS44312.1
    UniProtKB/Swiss-Prot
    Q9P2K3
    Related
    ENSP00000413929.2, ENST00000419091.6
    Conserved Domains (3) summary
    pfam00249
    Location:347390
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam01448
    Location:59110
    ELM2; ELM2 domain
    cl21498
    Location:146190
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  2. NM_001136224.4NP_001129696.2  REST corepressor 3 isoform b

    See identical proteins and their annotated locations for NP_001129696.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate 3' coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL590101, BC031608, BU689437, DC387352, HY024910
    Consensus CDS
    CCDS44313.1
    UniProtKB/Swiss-Prot
    Q9P2K3
    Related
    ENSP00000355973.4, ENST00000367006.8
    Conserved Domains (2) summary
    pfam01448
    Location:59110
    ELM2; ELM2 domain
    cl21498
    Location:146190
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  3. NM_001136225.3NP_001129697.1  REST corepressor 3 isoform c

    See identical proteins and their annotated locations for NP_001129697.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AA831517, AK131312, HY024910
    Consensus CDS
    CCDS44314.1
    UniProtKB/Swiss-Prot
    Q9P2K3
    Related
    ENSP00000398558.2, ENST00000452621.6
    Conserved Domains (3) summary
    pfam00249
    Location:347390
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam01448
    Location:59110
    ELM2; ELM2 domain
    cl21498
    Location:146190
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  4. NM_001350069.2NP_001336998.1  REST corepressor 3 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting isoform (e) has the same N- and C-termini, but is longer than isoform a.
    Source sequence(s)
    AK302664, AL590101, BU689437, DA925839, HY024910
    Conserved Domains (3) summary
    pfam00249
    Location:379422
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam01448
    Location:59142
    ELM2; ELM2 domain
    cl21498
    Location:178222
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  5. NM_001350070.2NP_001336999.1  REST corepressor 3 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate exon in its 5' UTR, resulting in the use of a downstream start codon compared to variant 1. The resulting isoform (f) has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AK302664, AL590101, AL611964, BU689437, DB164963, HY024910
    Conserved Domains (2) summary
    pfam00249
    Location:226269
    Myb_DNA-binding; Myb-like DNA-binding domain
    cl21498
    Location:2569
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  6. NM_018254.5NP_060724.1  REST corepressor 3 isoform d

    See identical proteins and their annotated locations for NP_060724.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AK001738, AL590101, BU689437, DA478986
    Consensus CDS
    CCDS31016.1
    UniProtKB/Swiss-Prot
    Q9P2K3
    Related
    ENSP00000355972.4, ENST00000367005.8
    Conserved Domains (3) summary
    pfam00249
    Location:289332
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam01448
    Location:152
    ELM2; ELM2 domain
    cl21498
    Location:88132
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RNA

  1. NR_146432.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate splice site in its 5' terminal exon and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD)
    Source sequence(s)
    AK302664, AL590101, BI051857, BU689437, DA334880, HY024910
  2. NR_146433.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK302664, AL590101, BI051857, BQ218032, BU689437, DC387352, HY024910
  3. NR_146434.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) contains an alternate internal exon, and it 3' terminal exon extends past a splice site that is used in variant 1.. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA831517, AI380424, AK302664, BI051857, BP221223, BQ218032, DA224160, DC387352, HY024910

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    211259366..211316385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448332.1XP_024304100.1  REST corepressor 3 isoform X14

    Conserved Domains (2) summary
    pfam01448
    Location:59142
    ELM2; ELM2 domain
    cl21498
    Location:178222
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  2. XM_005273191.5XP_005273248.1  REST corepressor 3 isoform X3

    Conserved Domains (3) summary
    pfam00249
    Location:348391
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam01448
    Location:60111
    ELM2; ELM2 domain
    cl21498
    Location:147191
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  3. XM_006711442.2XP_006711505.1  REST corepressor 3 isoform X11

    Conserved Domains (3) summary
    smart00717
    Location:146192
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam01448
    Location:60111
    ELM2; ELM2 domain
    cl21498
    Location:147191
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  4. XM_011509749.2XP_011508051.1  REST corepressor 3 isoform X8

    Conserved Domains (3) summary
    smart00717
    Location:146192
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam01448
    Location:60111
    ELM2; ELM2 domain
    cl21498
    Location:147191
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  5. XM_011509748.2XP_011508050.1  REST corepressor 3 isoform X4

    Conserved Domains (4) summary
    smart00717
    Location:322367
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:322365
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam01448
    Location:60111
    ELM2; ELM2 domain
    cl21498
    Location:147191
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  6. XM_017001764.2XP_016857253.1  REST corepressor 3 isoform X9

  7. XM_017001761.2XP_016857250.1  REST corepressor 3 isoform X5

  8. XM_017001758.2XP_016857247.1  REST corepressor 3 isoform X1

  9. XM_017001763.2XP_016857252.1  REST corepressor 3 isoform X7

  10. XM_017001762.2XP_016857251.1  REST corepressor 3 isoform X6

  11. XM_017001760.2XP_016857249.1  REST corepressor 3 isoform X2

  12. XM_017001765.2XP_016857254.1  REST corepressor 3 isoform X10

  13. XM_017001767.2XP_016857256.1  REST corepressor 3 isoform X15

    Related
    ENSP00000432779.1, ENST00000528926.5
  14. XM_024448331.1XP_024304099.1  REST corepressor 3 isoform X13

    Conserved Domains (2) summary
    pfam01448
    Location:60143
    ELM2; ELM2 domain
    cl21498
    Location:179223
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  15. XM_024448330.1XP_024304098.1  REST corepressor 3 isoform X12

    Conserved Domains (2) summary
    pfam00249
    Location:226269
    Myb_DNA-binding; Myb-like DNA-binding domain
    cl21498
    Location:2569
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RNA

  1. XR_001737306.2 RNA Sequence

  2. XR_001737302.2 RNA Sequence

  3. XR_001737303.2 RNA Sequence

  4. XR_001737304.2 RNA Sequence

  5. XR_001737300.2 RNA Sequence

  6. XR_001737310.2 RNA Sequence

  7. XR_001737301.2 RNA Sequence

  8. XR_001737308.2 RNA Sequence

  9. XR_001737305.2 RNA Sequence

  10. XR_001737307.2 RNA Sequence

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