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Rcor3 REST corepressor 3 [ Mus musculus (house mouse) ]

Gene ID: 214742, updated on 5-Mar-2024

Summary

Official Symbol
Rcor3provided by MGI
Official Full Name
REST corepressor 3provided by MGI
Primary source
MGI:MGI:2441920
See related
Ensembl:ENSMUSG00000037395 AllianceGenome:MGI:2441920
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4921514E24Rik; C730034D20Rik; E130101E15Rik
Summary
Enables enzyme binding activity. Predicted to be involved in histone deacetylation; negative regulation of transcription, DNA-templated; and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of histone deacetylase complex and transcription regulator complex. Is expressed in eye; genitourinary system; heart; and limb. Orthologous to human RCOR3 (REST corepressor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 10.4), ovary adult (RPKM 4.1) and 28 other tissues See more
Orthologs
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Genomic context

See Rcor3 in Genome Data Viewer
Location:
1 H6; 1 97.23 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (191782842..191822371, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (192098546..192138074, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene microRNA 3473c Neighboring gene TNF receptor-associated factor 5 Neighboring gene STARR-positive B cell enhancer ABC_E11114 Neighboring gene STARR-positive B cell enhancer ABC_E11115 Neighboring gene glutathione S-transferase, pi, pseudogene Neighboring gene predicted gene 10516 Neighboring gene predicted gene, 39745 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 1 Neighboring gene STARR-seq mESC enhancer starr_03453 Neighboring gene STARR-seq mESC enhancer starr_03454 Neighboring gene STARR-seq mESC enhancer starr_03455 Neighboring gene STARR-seq mESC enhancer starr_03457 Neighboring gene STARR-seq mESC enhancer starr_03458

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC28186

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of histone deacetylase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290278.2NP_001277207.1  REST corepressor 3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC175315, AC182250, LO018690
    Consensus CDS
    CCDS69996.1
    UniProtKB/Swiss-Prot
    Q6PGA0
    Related
    ENSMUSP00000106473.4, ENSMUST00000110849.10
    Conserved Domains (3) summary
    smart00717
    Location:143189
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam01448
    Location:57108
    ELM2; ELM2 domain
    cl21498
    Location:144188
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  2. NM_001290279.2NP_001277208.1  REST corepressor 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC175315, AC182250, LO018690
    Consensus CDS
    CCDS78777.1
    UniProtKB/TrEMBL
    A0A0A6YWY4
    Related
    ENSMUSP00000141753.2, ENSMUST00000192491.6
    Conserved Domains (2) summary
    pfam01448
    Location:57108
    ELM2; ELM2 domain
    cl21498
    Location:144188
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  3. NM_001290280.2NP_001277209.1  REST corepressor 3 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC175315, AC182250, LO018690
    Consensus CDS
    CCDS78778.1
    UniProtKB/TrEMBL
    A0A0A6YWP7
    Related
    ENSMUSP00000141637.2, ENSMUST00000192128.6
    Conserved Domains (4) summary
    smart00717
    Location:345390
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:345388
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam01448
    Location:57108
    ELM2; ELM2 domain
    cl21498
    Location:144188
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  4. NM_001290282.2NP_001277211.1  REST corepressor 3 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC175315, AC182250, LO018690
    UniProtKB/TrEMBL
    B2RSN6
    Conserved Domains (2) summary
    smart00717
    Location:2470
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cl21498
    Location:2569
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  5. NM_001346740.2NP_001333669.1  REST corepressor 3 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC175315, AC182250, LO018690
    Consensus CDS
    CCDS83667.1
    UniProtKB/TrEMBL
    A0A0A6YXM5
    Related
    ENSMUSP00000142054.2, ENSMUST00000192866.6
  6. NM_001403274.1NP_001390203.1  REST corepressor 3 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC175315, AC182250, LO018690
  7. NM_001403275.1NP_001390204.1  REST corepressor 3 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC182250, LO018690
  8. NM_144814.4NP_659063.3  REST corepressor 3 isoform a

    See identical proteins and their annotated locations for NP_659063.3

    Status: VALIDATED

    Source sequence(s)
    AC175315, AC182250, LO018690
    Consensus CDS
    CCDS69995.1
    UniProtKB/Swiss-Prot
    Q6PGA0
    UniProtKB/TrEMBL
    B2RSN6
    Related
    ENSMUSP00000073004.8, ENSMUST00000073279.13
    Conserved Domains (3) summary
    smart00717
    Location:143189
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam01448
    Location:57108
    ELM2; ELM2 domain
    cl21498
    Location:144188
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RNA

  1. NR_175372.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC175315, AC182250, LO018690
    Related
    ENSMUST00000192158.6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    191782842..191822371 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252872.2XP_030108732.2  REST corepressor 3 isoform X2

    Conserved Domains (2) summary
    pfam01448
    Location:139190
    ELM2; ELM2 domain
    cl21498
    Location:226270
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  2. XM_030252875.2XP_030108735.2  REST corepressor 3 isoform X3

    Conserved Domains (2) summary
    pfam01448
    Location:139190
    ELM2; ELM2 domain
    cl21498
    Location:226270
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  3. XM_006497244.4XP_006497307.1  REST corepressor 3 isoform X4

    See identical proteins and their annotated locations for XP_006497307.1

    Conserved Domains (3) summary
    pfam00249
    Location:226269
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam09770
    Location:269420
    PAT1; Topoisomerase II-associated protein PAT1
    cl21498
    Location:2569
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  4. XM_011238931.3XP_011237233.1  REST corepressor 3 isoform X4

    See identical proteins and their annotated locations for XP_011237233.1

    Conserved Domains (3) summary
    pfam00249
    Location:226269
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam09770
    Location:269420
    PAT1; Topoisomerase II-associated protein PAT1
    cl21498
    Location:2569
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  5. XM_030252885.2XP_030108745.2  REST corepressor 3 isoform X5

    Conserved Domains (2) summary
    pfam01448
    Location:139190
    ELM2; ELM2 domain
    cl21498
    Location:226270
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RNA

  1. XR_001783754.2 RNA Sequence

  2. XR_003954421.2 RNA Sequence

  3. XR_003954423.2 RNA Sequence

  4. XR_003954422.2 RNA Sequence

  5. XR_003954420.2 RNA Sequence

  6. XR_003954419.2 RNA Sequence