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TRPV5 transient receptor potential cation channel subfamily V member 5 [ Homo sapiens (human) ]

Gene ID: 56302, updated on 24-Nov-2020

Summary

Official Symbol
TRPV5provided by HGNC
Official Full Name
transient receptor potential cation channel subfamily V member 5provided by HGNC
Primary source
HGNC:HGNC:3145
See related
Ensembl:ENSG00000127412 MIM:606679
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAT2; ECAC1; OTRPC3
Summary
This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See TRPV5 in Genome Data Viewer
Location:
7q34
Exon count:
15
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (142908101..142933746, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (142605648..142630820, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene EPH receptor B6 Neighboring gene transient receptor potential cation channel subfamily V member 6 Neighboring gene uncharacterized LOC105375542 Neighboring gene uncharacterized LOC105375543

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
calcium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion transmembrane transport TAS
Traceable Author Statement
more info
 
calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium ion transport TAS
Traceable Author Statement
more info
PubMed 
protein homotetramerization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of urine volume ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
transient receptor potential cation channel subfamily V member 5
Names
calcium transport protein 2
calcium transporter 2
epithelial calcium channel 1
osm-9-like TRP channel 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046912.1 RefSeqGene

    Range
    4978..30623
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_019841.7NP_062815.3  transient receptor potential cation channel subfamily V member 5

    Status: REVIEWED

    Source sequence(s)
    AC245427, AF304464, BC034740
    Consensus CDS
    CCDS5875.1
    UniProtKB/Swiss-Prot
    Q9NQA5
    UniProtKB/TrEMBL
    A0A0A6YY98
    Related
    ENSP00000265310.1, ENST00000265310.6
    Conserved Domains (3) summary
    cd00204
    Location:79202
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:2705
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:117147
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    142908101..142933746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187562.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    931168..956813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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