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Mol Genet Genomic Med. 2019 Mar;7(3):e562. doi: 10.1002/mgg3.562. Epub 2019 Jan 21.

Association between single nucleotide polymorphism (rs4252424) in TRPV5 calcium channel gene and lead poisoning in Chinese workers.

Liu J1, Zhang L2,3, Feng L4, Xu M2,3, Gao Y2,3, Zhou P2,3, Yu Z2,3, Zhu B5, An Y1, Zhang H2,3.

Author information

1
Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China.
2
Department of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
3
Public Health Research Institute of Jiangsu Province, Nanjing, China.
4
Wuzhong City Center for Disease Control and Prevention, Wuzhong, China.
5
Nanjing Medical University, Nanjing, China.

Abstract

BACKGROUND:

Lead (Pb) is broadly used in various industries and causes irreversible damage to human tissues, organs, and systems. Studies have revealed that lead exerts toxic effects via interfering with calcium channel.

METHODS:

In the present study, we investigated whether single nucleotide polymorphisms (SNPs) in TRPV5, a calcium channel-related gene, were associated with lead exposure susceptibility. By using TaqMan SNP genotyping, we performed genotyping of eight TRPV5 tag-SNPs in 1,130 lead-exposed Chinese workers with similar lead exposure level.

RESULTS:

Single nucleotide polymorphism rs4252424 was significantly associated with lead susceptibility, measured by blood lead level (BLL) (β = -0.069, plinear  = 0.029). However, there was no significant association between any other seven SNPs and BLL. The further expression Quantitative Trait Loci displayed that CC genotype of rs4252424 is significant associated with higher BLL than CT (p < 0.0001).

CONCLUSION:

We conclude that SNP rs4252424 has the potential to evaluate lead susceptibility in the Chinese occupational population, and further enhance lead exposure prevention and intervention.

KEYWORDS:

TRPV5 polymorphism; blood lead levels; calcium channel; leadexposure susceptibility

PMID:
30666830
PMCID:
PMC6418352
DOI:
10.1002/mgg3.562
[Indexed for MEDLINE]
Free PMC Article

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