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TMX4 thioredoxin related transmembrane protein 4 [ Homo sapiens (human) ]

Gene ID: 56255, updated on 5-Mar-2024


Official Symbol
TMX4provided by HGNC
Official Full Name
thioredoxin related transmembrane protein 4provided by HGNC
Primary source
See related
Ensembl:ENSG00000125827 MIM:616766; AllianceGenome:HGNC:25237
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDIA14; TXNDC13; DJ971N18.2
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and C-terminal ASP/GLU-rich calcium binding domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The encoded protein has been shown to have reductase activity in vitro. [provided by RefSeq, Jan 2017]
Broad expression in testis (RPKM 50.0), heart (RPKM 24.6) and 24 other tissues See more
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Genomic context

See TMX4 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (7977346..8019761, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (8019162..8061561, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (7957993..8000408, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene serine and arginine rich splicing factor 10 pseudogene 2 Neighboring gene NANOG hESC enhancer GRCh37_chr20:7831618-7832119 Neighboring gene NANOG hESC enhancer GRCh37_chr20:7832120-7832620 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr20:7837050-7838249 Neighboring gene hydroxyacid oxidase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17535 Neighboring gene NANOG hESC enhancer GRCh37_chr20:7936767-7937438 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:7964803-7965420 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12666 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12667 Neighboring gene TMX4 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 13354 Neighboring gene Sharpr-MPRA regulatory region 6433 Neighboring gene phosphorylase kinase regulatory subunit beta pseudogene 1

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with TMX4; predicted interaction to be within the endoplasmic reticulum and function as thioredoxin reductase PubMed

Go to the HIV-1, Human Interaction Database


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Clone Names

  • KIAA1162

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables disulfide oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
is_active_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
located_in nuclear inner membrane ISS
Inferred from Sequence or Structural Similarity
more info

General protein information

Preferred Names
thioredoxin-related transmembrane protein 4
protein disulfide isomerase family A, member 14
thioredoxin domain containing 13
thioredoxin domain-containing protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021156.4NP_066979.2  thioredoxin-related transmembrane protein 4 precursor

    See identical proteins and their annotated locations for NP_066979.2

    Status: VALIDATED

    Source sequence(s)
    AL021396, BC021964, BC044777, HY011753
    Consensus CDS
    Q8N4P7, Q8NCC1, Q9H1E5, Q9UJA1, Q9ULQ8
    ENSP00000246024.2, ENST00000246024.7
    Conserved Domains (1) summary
    PDI_a_TMX; PDIa family, TMX subfamily; composed of proteins similar to the TRX-related human transmembrane protein, TMX. TMX is a type I integral membrane protein; the N-terminal redox active TRX domain is present in the endoplasmic reticulum (ER) lumen while the ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    7977346..8019761 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060944.1 Alternate T2T-CHM13v2.0

    8019162..8061561 complement
    GenBank, FASTA, Sequence Viewer (Graphics)