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TMX4 thioredoxin related transmembrane protein 4 [ Homo sapiens (human) ]

Gene ID: 56255, updated on 6-May-2021

Summary

Official Symbol
TMX4provided by HGNC
Official Full Name
thioredoxin related transmembrane protein 4provided by HGNC
Primary source
HGNC:HGNC:25237
See related
Ensembl:ENSG00000125827 MIM:616766
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDIA14; TXNDC13; DJ971N18.2
Summary
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and C-terminal ASP/GLU-rich calcium binding domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The encoded protein has been shown to have reductase activity in vitro. [provided by RefSeq, Jan 2017]
Expression
Broad expression in testis (RPKM 50.0), heart (RPKM 24.6) and 24 other tissues See more
Orthologs
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Genomic context

See TMX4 in Genome Data Viewer
Location:
20p12.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (7977346..8019761, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (7957993..8000408, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene serine and arginine rich splicing factor 10 pseudogene 2 Neighboring gene hydroxyacid oxidase 1 Neighboring gene uncharacterized LOC105372520 Neighboring gene 20p12 distal LINE-mediated recombination region Neighboring gene phosphorylase kinase regulatory subunit beta pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with TMX4; predicted interaction to be within the endoplasmic reticulum and function as thioredoxin reductase PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1162

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
thioredoxin-related transmembrane protein 4
Names
protein disulfide isomerase family A, member 14
thioredoxin domain containing 13
thioredoxin domain-containing protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021156.4NP_066979.2  thioredoxin-related transmembrane protein 4 precursor

    See identical proteins and their annotated locations for NP_066979.2

    Status: VALIDATED

    Source sequence(s)
    AL021396, BC021964, BC044777, HY011753
    Consensus CDS
    CCDS13101.1
    UniProtKB/Swiss-Prot
    Q9H1E5
    Related
    ENSP00000246024.2, ENST00000246024.7
    Conserved Domains (1) summary
    cd02994
    Location:37137
    PDI_a_TMX; PDIa family, TMX subfamily; composed of proteins similar to the TRX-related human transmembrane protein, TMX. TMX is a type I integral membrane protein; the N-terminal redox active TRX domain is present in the endoplasmic reticulum (ER) lumen while the ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    7977346..8019761 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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