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Becn1 beclin 1, autophagy related [ Mus musculus (house mouse) ]

Gene ID: 56208, updated on 2-Oct-2018

Summary

Official Symbol
Becn1provided by MGI
Official Full Name
beclin 1, autophagy relatedprovided by MGI
Primary source
MGI:MGI:1891828
See related
Ensembl:ENSMUSG00000035086 Vega:OTTMUSG00000002791
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Atg6
Expression
Ubiquitous expression in CNS E11.5 (RPKM 39.6), bladder adult (RPKM 35.6) and 28 other tissues See more
Orthologs

Genomic context

See Becn1 in Genome Data Viewer
Location:
11; 11 D
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (101288262..101302290, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (101149581..101163581, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene WNK lysine deficient protein kinase 4 Neighboring gene cytochrome C oxidase assembly factor 3 Neighboring gene cyclin N-terminal domain containing 1 Neighboring gene proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) Neighboring gene amine oxidase, copper containing 2 (retina-specific)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • Apelin signaling pathway, organism-specific biosystem (from KEGG)
    Apelin signaling pathway, organism-specific biosystemApelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various ti...
  • Apoptosis - multiple species, organism-specific biosystem (from KEGG)
    Apoptosis - multiple species, organism-specific biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
  • Apoptosis - multiple species, conserved biosystem (from KEGG)
    Apoptosis - multiple species, conserved biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
  • Autophagy - animal, organism-specific biosystem (from KEGG)
    Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Autophagy - animal, conserved biosystem (from KEGG)
    Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Autophagy - other, organism-specific biosystem (from KEGG)
    Autophagy - other, organism-specific biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...
  • Autophagy - other, conserved biosystem (from KEGG)
    Autophagy - other, conserved biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Deubiquitination, organism-specific biosystem (from REACTOME)
    Deubiquitination, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Macroautophagy, organism-specific biosystem (from REACTOME)
    Macroautophagy, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Mitophagy - animal, organism-specific biosystem (from KEGG)
    Mitophagy - animal, organism-specific biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
  • Mitophagy - animal, conserved biosystem (from KEGG)
    Mitophagy - animal, conserved biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Ub-specific processing proteases, organism-specific biosystem (from REACTOME)
    Ub-specific processing proteases, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC6843, 4921513J16Rik, 5430417M23Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GTPase binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol 3-kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
amyloid-beta metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiogenesis TAS
Traceable Author Statement
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
autophagy IDA
Inferred from Direct Assay
more info
PubMed 
autophagy ISO
Inferred from Sequence Orthology
more info
 
autophagy of mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagy of mitochondrion ISO
Inferred from Sequence Orthology
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucose starvation IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to nitrogen starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
engulfment of apoptotic cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
late endosome to vacuole transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
macroautophagy IGI
Inferred from Genetic Interaction
more info
PubMed 
macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitophagy ISO
Inferred from Sequence Orthology
more info
 
mitotic metaphase plate congression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of lysosome organization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of attachment of mitotic spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
 
positive regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cardiac muscle hypertrophy IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization by the Cvt pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor catabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of catalytic activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
response to mitochondrial depolarisation ISO
Inferred from Sequence Orthology
more info
 
response to other organism IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
dendrite ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extrinsic component of membrane ISO
Inferred from Sequence Orthology
more info
 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
colocalizes_with mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol 3-kinase complex, class III IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol 3-kinase complex, class III, type I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol 3-kinase complex, class III, type II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
beclin-1
Names
Bcl-2-interacting protein beclin
Beclin-1
coiled-coil, myosin-like BCL2-interacting protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359819.1NP_001346748.1  beclin-1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK032176, AK077392, CB723507
    Conserved Domains (2) summary
    pfam15285
    Location:2042
    BH3; Beclin-1 BH3 domain, Bcl-2-interacting
    pfam04111
    Location:48358
    APG6; Autophagy protein Apg6
  2. NM_001359820.1NP_001346749.1  beclin-1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation from an alternate start codon, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK032176, AK077392, CB723507
    Conserved Domains (1) summary
    pfam04111
    Location:31247
    APG6; Autophagy protein Apg6
  3. NM_001359821.1NP_001346750.1  beclin-1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 3' terminal exon and lacks several exons, compared to variant 1. It encodes isoform 4, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL590969
  4. NM_019584.4NP_062530.2  beclin-1 isoform 1

    See identical proteins and their annotated locations for NP_062530.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK032176, AK077392, CB723507
    Consensus CDS
    CCDS25462.1
    UniProtKB/Swiss-Prot
    O88597
    Related
    ENSMUSP00000119369.1, OTTMUSP00000002689, ENSMUST00000130916.7
    Conserved Domains (3) summary
    pfam04111
    Location:133444
    APG6; Autophagy protein Apg6
    pfam12777
    Location:194267
    MT; Microtubule-binding stalk of dynein motor
    pfam15285
    Location:105127
    BH3; Beclin-1 BH3 domain, Bcl-2-interacting

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    101288262..101302290 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533784.3XP_006533847.1  beclin-1 isoform X1

    Conserved Domains (2) summary
    pfam15285
    Location:2042
    BH3; Beclin-1 BH3 domain, Bcl-2-interacting
    pfam04111
    Location:48358
    APG6; Autophagy protein Apg6
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